Results 71 to 80 of about 55,204 (241)

Mitochondria and Endoplasmic Reticulum Contact Site as a Regulator of Proteostatic Stress Responses in Neurodegenerative Diseases

open access: yesBioEssays, EarlyView.
Recent findings indicate that mitochondria‐associated membranes (MAMs), where the endoplasmic reticulum directly contacts the mitochondria, are a novel microdomain essential for cellular homeostasis, including proteostasis. We summarize the disruption of protein homeostasis and MAM alteration in neurodegenerative diseases, then discuss challenges and ...
Seiji Watanabe, Koji Yamanaka
wiley   +1 more source

Partial purification of trypsin/papain inhibitors from Hymenaea courbaril L. seeds and antibacterial effect of protein fractions

open access: yesHoehnea
The crude extract and protein fractions of Hymenaea courbaril L. seeds were investigated for the presence of trypsin and papain inhibitors and antimicrobial activity against Vibrio parahaemolyticus, Staphylococcus aureus, and Escherichia coli.
Mônica Silva de Brito   +5 more
doaj   +1 more source

Acute kidney injury in critically ill cancer patients : an update [PDF]

open access: yes, 2016
Patients with cancer represent a growing group among actual ICU admissions (up to 20 %). Due to their increased susceptibility to infectious and noninfectious complications related to the underlying cancer itself or its treatment, these patients ...
Benoit, Dominique   +3 more
core   +2 more sources

The Molecular Toolbox for Linkage Type‐Specific Analysis of Ubiquitin Signaling

open access: yesChemBioChem, EarlyView.
Ubiquitin modifications regulate virtually all aspects of eukaryotic cell biology through an array of polyubiquitin chain signals that adopt distinct structures, enabling the individual polyubiquitin linkages to mediate specific functions in cells.
Julian Koch   +3 more
wiley   +1 more source

Overexpression of StCYS1 gene enhances tolerance to salt stress in the transgenic potato (Solanum tuberosum L.) plant

open access: yesJournal of Integrative Agriculture, 2020
Salt stress seriously restricts the growth and yield of potatoes. Plant cystatins are vital players in biotic stress and development, however, their roles in salt stress resistance remain elusive.
Min-min LIU   +6 more
doaj  

Serum Cystatin C as a Potential Marker for Glomerular Filtration Rate in Patients with Cholangiocarcinoma

open access: yesInternational Journal of Hematology-Oncology and Stem Cell Research, 2020
Background: Cholangiocarcinoma (CCA) is the second most common primary hepatobiliary cancer. These patients have meager prognosis and short-term survival. Precise assessment of glomerular filtration rate is a fundamental aspect of clinical care in cancer
Mang Ngaih Ciin   +5 more
doaj   +1 more source

Association of serum cystatin C level with coronary atherosclerotic plaque burden: a comprehensive analysis of observational studies and genetic study

open access: yesBMC Cardiovascular Disorders, 2023
Background and Aims Epidemiological studies show that high circulating cystatin C is associated with risk of cardiovascular disease (CVD), independent of creatinine-based renal function measurements.
Jun Chen   +6 more
doaj   +1 more source

Extracellular vesicles from adipose tissue - a potential role in obesity and type 2 diabetes? [PDF]

open access: yes, 2017
Adipose tissue plays a key role in the development of insulin resistance and its pathological sequelae such as type 2 diabetes and non-alcoholic fatty liver disease. Dysfunction in the adipose tissue response to storing excess fatty acids as triglyceride
Freeman, Dilys J.   +2 more
core   +1 more source

Contemporary Perspectives on Chronic Renal Disorders

open access: yesChronic Diseases and Translational Medicine, EarlyView.
ABSTRACT The prevalence of renal diseases and its associated burden on healthcare have tremendously risen in the past few years. From simple markers assessing kidney function, current renal research delves into understanding the diseases at the cellular and molecular levels and not just at treating, but at improving quality of life, arresting ...
Deenadhayalan Ashok   +5 more
wiley   +1 more source

Urinary Tubular Injury Biomarkers Are Associated With ESRD and Death in the REGARDS Study. [PDF]

open access: yes, 2018
IntroductionUrinary neutrophil gelatinase-associated lipocalin (uNGAL) and urinary kidney injury molecule-1 (uKIM-1) are established markers of subclinical acute kidney injury.
Bennett, Michael   +10 more
core  

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