Results 21 to 30 of about 19,945,001 (395)

Accuracy of GFR Estimating Equations in Patients with Discordances between Creatinine and Cystatin C-Based Estimations

Journal of the American Society of Nephrology, 2023
Significance Statement Large discordances between eGFR on the basis of creatinine (eGFRcr) or cystatin C (eGFRcys) are common in clinical practice. However, which GFR estimating equation (eGFRcr, eGFRcys, or eGFRcr-cys) is most accurate in these settings
Edouard L. Fu, A. Levey, J. Coresh, C. Elinder, J. Rotmans, F. Dekker, Julie M. Paik, P. Bárány, M. Grams, L. Inker, J. Carrero   +10 more
semanticscholar   +1 more source

Discordances Between Creatinine and Cystatin C-Based Estimated GFR and Adverse Clinical Outcomes in Routine Clinical Practice.

American Journal of Kidney Diseases, 2023
RATIONALE & OBJECTIVE Cystatin C is recommended for estimating glomerular filtration rate (eGFR) when estimates based on creatinine (eGFRcr) are not thought to be accurate enough for clinical decision making.
Juan-Jesús Carrero Pharm, Edouard L. Fu, Yingying Sang Biostat, S. Ballew, M. Evans, C. Elinder, P. Bárány, L. Inker, A. Levey, J. Coresh, M. Grams   +10 more
semanticscholar   +1 more source

Serum Cystatin C Levels Are Associated With Obesity in Adolescents Aged 14–17 Years

Frontiers in Endocrinology, 2022
BackgroundThe association between serum cystatin C levels and obesity has not been fully explored in adolescents. This study aimed to explore the association between serum cystatin C levels and obesity in adolescents of different sexes.MethodsWe ...
Ying-Xiang Huo, Wei Wei, Yang Liu, Ya-Nan Ma, Jun-Min Tao, Ning-Ning Wang, Xiao-Feng Li, Xin Chen   +7 more
doaj   +1 more source

Should Cystatin C eGFR Become Routine Clinical Practice?

Biomolecules, 2023
Kidney function assessment is crucial for diagnosing and managing kidney diseases. Glomerular filtration rate (GFR) is widely used as an indicator of kidney function, but its direct measurement is challenging. Serum creatinine, a commonly used marker for
S. Spencer, R. Desborough, S. Bhandari
semanticscholar   +1 more source

Megalin dependent urinary cystatin C excretion in ischemic kidney injury in rats. [PDF]

PLoS ONE, 2017
Cystatin C, a marker of kidney injury, is freely filtered in the glomeruli and reabsorbed by the proximal tubules. Megalin and cubilin are endocytic receptors essential for reabsorption of most filtered proteins.
Danny Jensen, Casper Kierulf-Lassen, Marie Louise Vindvad Kristensen, Rikke Nørregaard, Rikke Nørregaard, Kathrin Weyer, Rikke Nielsen, Erik Ilsø Christensen, Henrik Birn   +8 more
doaj   +1 more source

Comparison of Cystatin C and Creatinine in the Assessment of Measured Kidney Function during Critical Illness

American Society of Nephrology. Clinical Journal, 2023
Visual Abstract Background Incomplete recovery of kidney function is an important adverse outcome in survivors of critical illness. However, unlike eGFR creatinine, eGFR cystatin C is not confounded by muscle loss and may improve identification of ...
R. Haines, A. Fowler, Kaifeng Liang, R. Pearse, A. Larsson, Z. Puthucheary, J. Prowle   +6 more
semanticscholar   +1 more source

Association of vancomycin plus piperacillin–tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study

Intensive Care Medicine, 2022
Although dozens of studies have associated vancomycin + piperacillin–tazobactam with increased acute kidney injury (AKI) risk, it is unclear whether the association represents true injury or a pseudotoxicity characterized by isolated effects on ...
T. Miano, S. Hennessy, Wei Yang, T. Dunn, A. Weisman, O. Oniyide, R. Agyekum, A. Turner, C. Ittner, B. Anderson, F. Wilson, R. Townsend, J. Reilly, H. Giannini, C. Cosgriff, T. Jones, N. Meyer, M. Shashaty   +17 more
semanticscholar   +1 more source

Assessment of Cystatin C Level for Risk Stratification in Adults With Chronic Kidney Disease

JAMA Network Open, 2022
Key Points Question Does estimation of kidney function by cystatin C level improve risk-stratification for cardiovascular disease and mortality? Findings In this cohort study, patients with estimated glomerular filtration rate based on serum creatinine ...

semanticscholar   +1 more source

Cystatine C et risque cardiovasculaire [PDF]

Annales de biologie clinique, 2009
Abstract Background: Patients with chronic kidney disease (CKD) are at high risk for developing cardiovascular disease (CVD) and cardiovascular events. Cystatin C, a protease inhibitor synthesized in all nucleated cells, has been proposed as a replacement for serum creatinine for the assessment of renal function, particularly to detect ...
TAGLIERI, NEVIO, Koenig W, Kaski C.
openaire   +8 more sources

Advantages, Limitations, and Clinical Considerations in Using Cystatin C to Estimate GFR

Kidney360, 2022
Cystatin C has been shown to be a reliable and accurate marker of kidney function across diverse populations. The 2012 Kidney Disease Improving Global Outcomes (KDIGO) guidelines recommended using cystatin C to confirm the diagnosis of chronic kidney ...
Debbie C. Chen, O. A. Potok, D. Rifkin, M. Estrella   +3 more
semanticscholar   +1 more source