Results 81 to 90 of about 37,835 (197)

NMR STUDIES OF HUMAN CYSTATIN C – STABLE ISOTOPE LABELING OF HUMAN CYSTATIN C

TASK Quarterly, 2014
The objective of this study was to obtain a double and triple labeled human cystatin C (hCC). Another objective was to record sets of 2D and 3D NMR spectra of the hCC dimer (in a solution) using a 700MHz spectrometer.
PRZEMYSŁAW JURCZAK, MARTYNA MASZOTA-ZIELENIAK   +1 more
doaj   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Causal association between cystatin C and diabetic retinopathy: A two‐sample Mendelian randomization study

Journal of Diabetes Investigation
Objective To explore the causal relationship between cystatin C levels and different stages of diabetic retinopathy through Mendelian randomization (MR).
Yimeng Ruan, Ping Zhang, Xiangzhe Li, Xinru Jia, Dongwei Yao   +4 more
doaj   +1 more source

Migraine and patent foramen ovale: correlation, coexistence, dependence. A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Plain Language Summary This review looked at what scientists know about the connection between migraine and a small heart opening called a patent foramen ovale (PFO). It showed that people with migraine, especially with aura, often have PFO, but it is not certain whether closing this heart opening helps prevent strokes in these patients.
Olga Grodzka, Michał Borończyk, Anna Zduńska, Julia Węgrzynek‐Gallina, Izabela Domitrz, Anetta Lasek‐Bal   +5 more
wiley   +1 more source

Serum cystatin C: A surrogate marker for the characteristics of peritoneal membrane in dialysis patients

Saudi Journal of Kidney Diseases and Transplantation, 2009
To evaluate whether cystatin C levels can be a surrogate marker of creatinine clearance and reflect the characteristics of peritoneal membrane in dialysis patients, we performed peritoneal equilibration tests (PET) in 18 anuric adult chronic peritoneal ...
Al-Wakeel Jamal, Hammad Durdana, Memon Nawaz, Tarif Nauman, Shah Iqbal, Chaudhary Abdulrauf   +5 more
doaj  

Efficacy of luseogliflozin for renal function preservation in patients with type 2 diabetes mellitus and impaired renal function: A randomized open‐label clinical trial (RESOLUTION study)

Journal of Diabetes Investigation, EarlyView.
Luseogliflozin alleviated renal function decline (eGFR) after an initial decrease, showing renoprotective effects in patients with renal impairment. Luseogliflozin did not increase renal events, showing safety even in patients with moderate‐to‐severe renal impairment.
Munehiro Kitada, Masao Toyoda, Osamu Sekine, Daisuke Suzuki, Yosuke Okada, Yoshikata Morita, Hideki Nishimura, Hiroaki Satoh, Hideki Kamiya, Toshinari Takamura, Motohide Isono, Takeshi Onoue, Hiroshi Arima, Kenichi Tanaka, Masaji Miyamoto, Yasushi Omura, Daisuke Yabe, Takehiro Kato, Akimichi Asano, Yutaka Wakasa, Satoshi Miyamoto, Shinji Kume, Tomohiko Ito, Shin‐ichi Araki, Atsushi Nakagawa, RESOLUTION Study Investigators   +25 more
wiley   +1 more source

Different eGFR markers and prediction of cardiovascular risk

Journal of Internal Medicine, EarlyView.
Abstract Background Renal dysfunction increases cardiovascular (CV) risk. We compared cystatin C‐based estimated glomerular filtration rate (eGFRcys), creatinine‐based eGFR (eGFRcr), and their ratio (eGFRcys/eGFRcr) in relation to major adverse cardiovascular events (MACE) and all‐cause mortality in chronic coronary syndrome, assessing the added ...
Maria Tydén, Gorav Batra, Bengt Fellström, Claes Held, Johan Lindbäck, Inga Soveri, Maria K. Svensson, Ralph Stewart, Harvey D. White, Lars Wallentin   +9 more
wiley   +1 more source

Electrophoretic patterns of proteinuria in dogs with Cushing’s syndrome

Journal of Small Animal Practice, EarlyView.
Objectives To describe the electrophoretic pattern of proteinuria in dogs with naturally occurring Cushing’s syndrome. We hypothesised that urine protein electrophoresis in dogs with spontaneous Cushing’s syndrome will reveal glomerular proteinuria. We also hypothesised that the severity of proteinuria would decrease during treatment with trilostane ...
J. Milenkovic, T. Francey, A. Schweighauser, J. Howard, S. Kittl, M. Campos   +5 more
wiley   +1 more source

Differentially Expressed Salivary miRNAs in Temporomandibular Disorders

Orthodontics &Craniofacial Research, EarlyView.
ABSTRACT Objective Temporomandibular disorders (TMDs) are heterogeneous conditions of unclear aetiology involving the temporomandibular joint, masticatory muscles and neural tissues. Limited understanding of their pathogenesis hampers accurate diagnosis and targeted treatment. Therefore, this study aimed to identify salivary microRNA (miRNA) signatures
Karolina Elżbieta Kaczor‐Urbanowicz, Mohammad Aziz, Holly Wilhalme, Sharon Aronovich, Elizabeth Rae Hatfield, Tara Aghaloo, Sherwin Arman, Aida Mohammadi, Mohammed Husain, Sotirios Tetradis, David Elashoff, Matteo Pellegrini, David T. W. Wong, Sunil Kapila   +13 more
wiley   +1 more source