The role of cystatin C as a proteasome inhibitor in multiple myeloma
Objectives: Bone destruction and renal impairment are two frequent complications of multiple myeloma (MM). Cystatin C, an extracellular cysteine proteinase inhibitor, is encoded by the housekeeping gene CST3 and associated with human tumors.
Yijing Jiang+7 more
semanticscholar +1 more source
BackgroundChronic kidney disease (CKD) impacts prognosis in patients undergoing transcatheter aortic valve implantation (TAVI). While estimated glomerular filtration rate (eGFR) calculated from serum creatinine [eGFR (creatinine)] is affected by body ...
Yusuke Kure+11 more
doaj +1 more source
Regulation of glial development by cystatin C [PDF]
AbstractCystatin C (CysC) is an endogenous cysteine proteases inhibitor produced by mature astrocytes in the adult brain. Previously we isolated CysC as a factor activating the glial fibrillary acidic protein (GFAP) promoter, and showed that CysC is expressed in astrocyte progenitors during development.
Kazuhiro Ikenaka+10 more
openaire +3 more sources
The Comparison of Creatinine and Cystatin C Value in Preeclampsia Severity and Neonatal Outcome [PDF]
Objectives: to compare the levels of creatinine and cystatin C with the severity of preeclampsia, and assess neonatal outcomes.Materials and Methods: Creatinine, cystatin C, and neonatal outcomes were assesed in 17 normotensive samples, 17 samples of ...
Wantania, J. (John)+1 more
core
Assessing the Diagnostic Power of Cystatin C and Creatinine in Detection of Chronic Kidney Disease [PDF]
Introduction: In patients with renal disorders, a sudden decrease in glomerular filtration rate (GFR) would not result in rapid rise concentrations of Creatinine.
Azizmohammad Looha, Mehdi+5 more
core +2 more sources
Kidney Fibrosis In Vitro and In Vivo Models: Path Toward Physiologically Relevant Humanized Models
This review discusses kidney diseases with a focus on kidney fibrosis and the models currently used. It highlights the limitations of animal and 2D in vitro models in replicating human kidney anatomy and physiology. Consequently, there is a significant need for humanized 3D in vitro models, such as 3D cell aggregates, membranes and hydrogels, on‐chip ...
Gabriele Addario+2 more
wiley +1 more source
Prevention of domain swapping inhibits dimerization and amyloid fibril formation of cystatin C : use of engineered disulfide bridges, antibodies, and carboxymethylpapain to stabilize the monomeric form of cystatin C [PDF]
Amyloidogenic proteins like cystatin C and prion proteins have been shown to form dimers by exchange of subdomains of the monomeric proteins. This process, called "three-dimensional domain swapping," has also been suggested to play a part in the ...
Grubb, Anders+9 more
core +1 more source
This review article explores applications in wearable sensors such as mechanical, electrophysiological, and gas sensors, highlighting advancements that improve device performance and predictability. In addition to analyzing graphene's synthesis techniques, including traditional and advanced laser‐based methods, the article discusses fabrication ...
Fatemeh Saeedi+2 more
wiley +1 more source
CLINICAL ANALYSIS OF ASSOCIATION OF CYSTATIN C AND ATRIAL FIBRILLATION
Some studies have disclosed atrial fibrillation (AF) is associated with inflammation. Cystatin C is not only inflammatory markers but also an independent predictor of cardiovascular events.Aim.
Ping Liu, Shujian Sui, Dongling Xu
doaj +3 more sources
Classifying finite-dimensional C*-algebras by posets of their commutative C*-subalgebras [PDF]
We consider the functor C that to a unital C*-algebra A assigns the partial order set C(A) of its commutative C*-subalgebras ordered by inclusion. We investigate how some C*-algebraic properties translate under the action of C to order-theoretical properties.
arxiv +1 more source