Results 101 to 110 of about 61,196 (252)

Human μ-calpain: Simple isolation from erythrocytes and characterization of autolysis fragments [PDF]

, 2001
Heterodimeric μ-calpain, consisting of the large (80 kDa) and the small (30 kDa) subunit, was isolated and purified from human erythrocytes by a highly reproducible four-step purification procedure.
Crawford C., Croall D. E., Graham-Siegenthaler K., Guroff G., Kitahara A., McClelland P., Nishimura T., Sasaki T., Sorimachi H., Sorimachi H., Sorimachi H., Thompson V.F., Yoshimura N., Zimmermann U.J.P.   +13 more
core   +1 more source

Disordered Bile Acid Metabolism in Alcohol‐Related Hepatitis

Alimentary Pharmacology &Therapeutics, EarlyView.
Serum conjugated primary bile acids accumulate in alcohol‐related hepatitis due to downregulation of hepatocyte bile acid transporters. Hepatocyte growth factor is elevated in alcohol‐related hepatitis and downregulates BSEP expression. This detrimentally affects the hepatoprotective adaptive reduction in NTCP/increase in BSEP seen in cholestasis ...
Luke D. Tyson, Stephen Atkinson, Benjamin H. Mullish, Alexandros Pechlivanis, Michael Allison, Andrew Austin, Katie Chappell, Stuart J. Forbes, Ewan H. Forrest, Alastair M. Kilpatrick, Tong Liu, Laura Martinez‐Gili, Steven Masson, Mark J. W. McPhail, Joao Nunes, Paul Richardson, Daniel Rodrigo‐Torres, Stephen D. Ryder, Mark Wright, Vishal C. Patel, Nikhil Vergis, Elaine Holmes, Mark R. Thursz   +22 more
wiley   +1 more source

Cystatin C as a Biomarker for Identifying High-Risk Patients with Acute Coronary Syndrome: An Observational Study

Clinical and Applied Thrombosis/Hemostasis
Background Cystatin C is a cysteine protease inhibitor, synthesized by nucleated cells, and released into various body fluids. Lots of studies have reported an association between cystatin C and atherosclerotic cardiovascular disease.
Xinlin Xiong MD, Li Yuan MB, Xiaobin Long MM, Minsheng An MB, Shen Huang MM, Liang Liu MB   +5 more
doaj   +1 more source

Acute kidney injury and post-reperfusion syndrome in liver transplantation [PDF]

, 2016
In the past decades liver transplantation (LT) has become the treatment of choice for patients with end stage liver disease (ESLD). The chronic shortage of cadaveric organs for transplantation led to the utilization of a greater number of marginal donors
Evison, Felicity, Ferguson, James, Gunson, Bridget, Mitterhofer, Anna Paola, Muiesan, Paolo, Scalera, Irene, Sharif, Adnan, Tinti, Francesca, Umbro, Ilaria   +8 more
core   +3 more sources

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Cystatin C proteoforms in chronic kidney disease

PLoS ONE, 2023
Cystatin C, a cysteine protease inhibitor, is used as a biomarker of renal function. It offers several advantages compared to creatinine, and formulas for the estimation of the glomerular filtration rate based on cystatin C have been developed. Recently,
Helene Dahl, Klaus Meyer, Kristina Sandnes, Natasha Lervaag Welland, Iselin Arnesen, Hans-Peter Marti, Jutta Dierkes, Vegard Lysne   +7 more
doaj  

Breeding drought tolerant cowpea: constraints, accomplishments, and future prospects [PDF]

, 2009
This review presents an overview of accomplishments on different aspects of cowpea breeding for drought tolerance. Furthermore it provides options to enhance the genetic potential of the crop by minimizing yield loss due to drought stress. Recent efforts
Agbicodo, A.C.M.E., Fatokun, C.A., Linden, C.G., van der, Muranaka, S., Visser, R.G.F.   +4 more
core   +2 more sources

TREM2 in Macrophages Promotes Renal Fibrosis via Activation of β‐Catenin Signalling Pathway in Obstructive Nephropathy

Cell Proliferation, EarlyView.
Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) promotes obstructive nephropathy progression by activating the β‐catenin signalling pathway, driving M2 macrophage polarisation, migration and fibrogenic gene expression. targeted inhibition of TREM2 thus represents a promising novel strategy against renal fibrosis.
Jia Wei, Zixia Li, Gengyu Du, Ting Chen, Min Yang, Zhen Yuan, Yidan Zheng, Xiang Yan   +7 more
wiley   +1 more source

A p38MAPK/MK2 signaling pathway leading to redox stress, cell death and ischemia/reperfusion injury [PDF]

, 2014
Background Many diseases and pathological conditions are characterized by transient or constitutive overproduction of reactive oxygen species (ROS).
Ashraf, Muhammad Imtiaz, Brandacher, Gerald, Dragun, Duska, Ebner, Matthias, Enthammer, Marion, Haller, Martina, Hermann, Martin, Khalid, Sana, Koziel, Katarzyna, Santer, Peter, Schwelberger, Hubert, Sickinger, Stephan, Soleiman, Afschin, Steger, Christina, Sucher, Robert, Troppmair, Jakob, Vallant, Stephanie, Wallner, Christoph   +17 more
core   +2 more sources

Estimated Glomerular Filtration Rate Change and Heart Failure Events With GLP‐1 Receptor Agonists: A Meta‐Analysis and Meta‐Regression of Randomised Controlled Trials

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To examine whether on‐treatment changes in kidney function and cardiometabolic markers are associated with the magnitude of heart failure (HF) risk reduction across large‐scale trials of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs).
Masashi Hasebe, Hisashi Kamido, Chen‐Yang Su, Yamato Keidai, Daisuke Yabe, Satoshi Yoshiji   +5 more
wiley   +1 more source