Results 91 to 100 of about 33,345 (227)

Corticosteroids significantly increase cystatin C levels in the plasma by promoting cystatin C production in rats

Renal Failure, 2019
Background: Several studies have shown that non-renal factors such as corticosteroids may increase plasma cystatin C levels without affecting kidney function. However, the mechanisms underlying this are unclear.
Xiao-Ran Zhu, Ning Ge, Yu Wang, Jian-Long Zhai, Chao Liu   +4 more
doaj   +1 more source

Oxidative Stress Drives Cell Cycle Stalling, Apoptosis and Metabolic Suppression in Cystatin B Deficient EPM1 Patient iPSCs

Cell Proliferation, EarlyView.
CSTB deficient EPM1 iPS cells manifest increased lysosomal activity and oxidative stress, which lead to DNA damage, cell cycle defects and increased apoptosis. As a protective response, metabolism is suppressed. Image created by BioRender https://BioRender.com/t44oc6h.
Shekhar Singh, Lidiia Plotnikova, Teemu Tiukuvaara, Reetta Kälviäinen, Riikka H. Hämäläinen   +4 more
wiley   +1 more source

Cystatin C Predicts Incident Cardiovascular Disease in Twins

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundCystatin C is associated with both renal function and atherosclerotic cardiovascular disease (ASCVD). We have previously shown a genetic correlation between cystatin C and prevalent ASCVD.
Johannes Arpegård, Patrik K. E. Magnusson, Xu Chen, Peter Ridefelt, Nancy L. Pedersen, Ulf De Faire, Per Svensson   +6 more
doaj   +1 more source

Effectiveness of Telehealth Low‐Carbohydrate Intervention in Preventing Chronic Kidney Disease: A Real‐World, Retrospective, Matched Cohort Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Lifestyle interventions targeting metabolic health may influence chronic kidney disease (CKD) risk, particularly among adults with type 2 diabetes and obesity. We evaluated real‐world associations between a telehealth‐delivered, individualized nutrition therapy program (VINT) and CKD incidence and progression compared with usual ...
Shaminie J. Athinarayanan, Petter Bjornstad, Priya V. Shanmugam, Thomas Weimbs, Adam J. Wolfberg, Jeff S. Volek, Jonathan Himmelfarb, Richard J. Johnson   +7 more
wiley   +1 more source

Clinical Association of Cystatin C and Atrial Fibrillation in Chinese Elderly

International Journal of Gerontology, 2015
Background: Atrial fibrillation (AF) is associated with inflammation. Cystatin C is not only an inflammatory marker but also an independent predictor of cardiovascular events.
Ping Liu, Yunqi Jiang, Juan Meng
doaj   +1 more source

Feasibility of Decentralised Response‐Guided Albuminuria Monitoring to Optimise Empagliflozin and Finerenone Therapy in Type 2 Diabetes and Chronic Kidney Disease

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To assess the feasibility of a decentralised response‐guided trial and to characterise urinary albumin‐to‐creatinine ratio (UACR) responses to empagliflozin and finerenone in type 2 diabetes and chronic kidney disease (CKD). Materials and Methods Adults with type 2 diabetes, estimated glomerular filtration rate (eGFR) ≥ 25 mL/min/1.73 m2,
Jelle M. Beernink, Gozewijn D. Laverman, Hiddo J. L. Heerspink   +2 more
wiley   +1 more source

Causal association between cystatin C and diabetic retinopathy: A two‐sample Mendelian randomization study

Journal of Diabetes Investigation
Objective To explore the causal relationship between cystatin C levels and different stages of diabetic retinopathy through Mendelian randomization (MR).
Yimeng Ruan, Ping Zhang, Xiangzhe Li, Xinru Jia, Dongwei Yao   +4 more
doaj   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

Combined sleep behaviors, mediating biomarkers, and incident vascular complications among individuals with type 2 diabetes: A prospective study in UK Biobank

Journal of Diabetes Investigation, EarlyView.
Among UK Biobank participants with type 2 diabetes, combined healthy sleep behaviors were associated with lower risks of vascular complications. Lipid and inflammatory biomarkers partially mediated these associations. ABSTRACT Aims To prospectively examine how combined sleep behaviors affect vascular complications in type 2 diabetes, whether these ...
Yanqiu Zou, Xia Jiang, Jinyu Zhou, Tao Han, Sirui Zheng, Mingshuang Tang, Yutong Wang, Lin Chen, Lingli Qiu, Xuan Wu, Zhixin Tan, Yunjie Liu, Bowen Lei, Xiaofeng Ma, Di Zhang, Jiaqiang Liao, Jiayuan Li, Ben Zhang, Mengyu Fan   +18 more
wiley   +1 more source