Results 91 to 100 of about 34,990 (232)

Shared dysregulation of complement and phosphorylation pathways in the cerebrospinal fluid of encephalitis, Aicardi–Goutières syndrome, and autism

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To identify shared and disorder‐specific molecular alterations across encephalitis, Aicardi–Goutières syndrome (AGS), and autism spectrum disorder (ASD) using cerebrospinal fluid (CSF) proteomics. Method In this cross‐sectional case–control study, mass‐spectrometry‐based proteomics was performed on archived CSF samples collected between ...
Omar H. Shadid, Peter G. Hains, Velda X. Han, Jingya Yan, Michael Griffiths, Ignatius Pang, Sushil Bandodkar, Phillip J. Robinson, Russell C. Dale   +8 more
wiley   +1 more source

Long-term cystatin C trajectories and cognitive decline in diabetes and non-diabetes: evidence from a national Chinese cohort

Frontiers in Medicine
BackgroundThe relationship between Cystatin C levels and cognitive function remains unclear. This study aims to investigate the association between cumulative changes and trajectory patterns of Cystatin C and cognitive decline in diabetes and non ...
Xiangyang Zhou, Yuguang Zhao, Huaqiao Huo, Wenwen Cheng, Aiwen Feng, Shuang Wang   +5 more
doaj   +1 more source

Nephroprotective Effects of the Dual GCGR/GLP‐1R Agonist Survodutide in Hypertension‐Accelerated Diabetic Kidney Disease

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Survodutide is a novel long‐acting dual glucagon (GCGR)/glucagon‐like peptide‐1 (GLP‐1R) receptor agonist currently in phase‐3 clinical development for the treatment of people living with obesity and metabolic dysfunction‐associated steatohepatitis.
Alexander Hamilton, Louise Thisted, Maria Ougaard, Max Hahn, Kasper Andersen, Johanna Perens, Robert Augustin, Besnik Bajrami, Wolfgang Rist, Michael Christensen, Henrik H. Hansen, Thomas Klein   +11 more
wiley   +1 more source

Plasma proenkephalin‐a facilitates measurement of human kidney functional reserve: From healthy kidney donors to polymorbid patients

Physiological Reports
Reduced kidney functional reserve, KFR, predicts poor outcomes in kidney diseases. We compared plasma proenkephalin‐A, plasma cystatin C, and creatinine clearance for kidney functional reserve measurement.
Camila Eleuterio Rodrigues, Amy Y. M. Au, Daniel Rebello, Maria Maawad, Florian Uhle, Jonathan Erlich, Zoltan H. Endre   +6 more
doaj   +1 more source

Clinical comparison of mouthrinse and orodispersible film containing cystatins and a statherin‐derived peptide against initial dental erosion

European Journal of Oral Sciences, EarlyView.
Abstract This randomized crossover in vivo study compared the anti‐erosive efficacy of solution and orodispersible film (ODF) formulations containing three cystatins (CaneCPI‐5, MaquiCPI‐3, and CsinCPI‐2) combined with a statherin‐derived peptide (StN15pSpS).
Marília Afonso Rabelo Buzalaf, Even Akemi Taira, Gustavo Cassalate da Silva, Mariana Miranda de Brito, Talita Mendes Oliveira Ventura, Flávio Henrique‐Silva, João Guilherme Medeiros, Thiago Saads Carvalho, Andrea Soares da Costa Fuentes, Karina Fan, Reinaldo Marchetto, Adrian Lussi, Vinícius Taioqui Pelá   +12 more
wiley   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Cystatin C Predicts Incident Cardiovascular Disease in Twins

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundCystatin C is associated with both renal function and atherosclerotic cardiovascular disease (ASCVD). We have previously shown a genetic correlation between cystatin C and prevalent ASCVD.
Johannes Arpegård, Patrik K. E. Magnusson, Xu Chen, Peter Ridefelt, Nancy L. Pedersen, Ulf De Faire, Per Svensson   +6 more
doaj   +1 more source

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

Distinct Microbial and Host Proteome Signatures Relate to Proteolytic Activity in Gingival Crevicular Fluid in an Exploratory Study of Patients With Periodontitis

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim Risk assessment tools for periodontitis lack sufficient precision to predict disease progression. The aim of this exploratory study was to evaluate proteolytic activity (PA) in gingival crevicular fluid in relation to clinically assessed progression risk, microbial community composition and host proteome. Materials and Methods Samples were
Miguel Carda‐Diéguez, Stefan Rüdiger, Gunnel Svensäter, Henrik Jansson, Tirthankar Mohanty, Yashuan Chao, Christofer Karlsson, Johan Malmström, Oonagh Shannon, Álex Mira, Julia R. Davies   +10 more
wiley   +1 more source

Cystatin C for gentamicin dosing

Biochemia medica
The study aims to present a case study of a patient with supratherapeutic serum gentamicin concentration. An 83-year-old male was admitted to the Department of Internal Medicine for persistent loss of appetite, decompensated heart failure, and pneumonia.
Šálek, Tomáš, Klhůfek, Josef, Vodička, Martin, Pšenčík, Marek   +3 more
openaire   +3 more sources