Results 111 to 120 of about 61,196 (252)
Circulating cathepsin K and cystatin C in patients with cancer related bone disease: Clinical and therapeutic implications [PDF]
, 2007 The clinical significance of serum cathepsin K and cystatin C was assessed in patients with breast cancer (BCa) or prostate cancer (PCa) with confined disease (M0) or bone metastasis (BM).
CRESCIMANNO, Marilena +3 more
core +1 more source
The FEBS Journal, EarlyView.Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley +1 more source
A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, EarlyView.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
The Multi-Biomarker Approach for Heart Failure in Patients with Hypertension [PDF]
, 2015 We assessed the predictive ability of selected biomarkers using N-terminal pro-brain natriuretic peptide (NT-proBNP) as the benchmark and tried to establish a multi-biomarker approach to heart failure (HF) in hypertensive patients. In 120 hypertensive
Agata Bielecka-Dabrowa +10 more
core +2 more sources
The FEBS Journal, EarlyView.The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka +3 more
wiley +1 more source
Cystatin C Predicts Incident Cardiovascular Disease in Twins
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundCystatin C is associated with both renal function and atherosclerotic cardiovascular disease (ASCVD). We have previously shown a genetic correlation between cystatin C and prevalent ASCVD.
Johannes Arpegård +6 more
doaj +1 more source
Cystatin C and renal function in pediatric kidney transplant recipients [PDF]
, 2009 In clinical practice, the glomerular filtration rate (GFR) is often determined with serum creatinine. However, studies have shown cystatin C to be a better parameter for the diagnosis of impaired renal function.
Franco, Maria do Carmo Pinho +5 more
core +1 more source
PEG400 regulates Falcipain 2 activity through an allosteric mechanism
The FEBS Journal, EarlyView.Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath +2 more
wiley +1 more source
Clinical Association of Cystatin C and Atrial Fibrillation in Chinese Elderly
International Journal of Gerontology, 2015 Background: Atrial fibrillation (AF) is associated with inflammation. Cystatin C is not only an inflammatory marker but also an independent predictor of cardiovascular events.
Ping Liu, Yunqi Jiang, Juan Meng
doaj +1 more source
Algorithms in Allergy: Molecular Allergology in the Context of Animal Allergy
Allergy, EarlyView.
Christiane Hilger +4 more
wiley +1 more source