Results 121 to 130 of about 34,990 (232)

Pragmatic Screening for Sarcopenia in Non‐Small Cell Lung Cancer: Development and Internal Validation of a Prospective Risk Model Integrating T12 CT Indices and Routine Clinical Variables

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Sarcopenia or low muscle mass is common in non‐small cell lung cancer and predicts poorer outcomes, but its assessment typically relies on CT‐based skeletal muscle index at the L3 vertebral level. Standard chest CTs often omit the L3 level, leaving many patients without a straightforward muscle mass measure, so sarcopenia frequently
Zhuorui You, Wei Dai, Hechen Shen, Xing Wei, Cheng Lei, Jia Liao, Jieming Cao, Minxian Li, Jia Wang, Mengqi Shao, Gang Li   +10 more
wiley   +1 more source

Skeletal Muscle Index, Tumor and Systemic Immunity, and Survival in Advanced Pancreatic Ductal Adenocarcinoma

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background This study investigated relationships between the skeletal muscle index (SMI) and the tumor immune microenvironment (TIME), peripheral immune phenotypes, and serum biomarkers in advanced pancreatic ductal adenocarcinoma (PDAC) and evaluated the prognostic significance of these parameters.
Yue Ma, Ru Jia, Mengjiao Fan, Guochao Deng, Tieqiang Liu, Yanrong Wang, Yue Li, Nan Zhang, Fang Pang, Yue Shi, Yaoyue Zhang, Yuting Pan, Qi Wang, Zhikuan Wang, Guanghai Dai   +14 more
wiley   +1 more source

Phytochemical Analysis of Moroccan Mercurialis annua L. and Its Nephroprotective Activity: Evidence Supporting Traditional Renal Uses

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Mercurialis annua L.: Phytochemistry and Nephroprotective Activity. ABSTRACT Mercurialis annua L. (Euphorbiaceae) is traditionally used to treat renal disorders, although its nephroprotective activity remains poorly documented. This study characterized the phytochemical profile of the Moroccan hydroethanolic extract by UHPLC–ESI/MS, evaluated its acute
Abdeljalil Elmahdaoui, Manal Zefzoufi, Lansine Diakité, Mohammed Haida, Rabiaa Fdil, Aziz Auhmani, Stefania Garzoli, Zahra Sokar   +7 more
wiley   +1 more source

Polyphenols as Natural Therapeutics for Dental Infections and Oral Inflammation: Mechanisms and Clinical Perspectives

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Polyphenol‐rich plant extracts provide natural immunomodulatory protection for oral health through complementary antioxidant, antibacterial, and anti‐inflammatory actions. Their potential to reduce harmful microbial activity and inflammation highlights the promise of dietary polyphenols as a natural strategy for maintaining oral health and preventing ...
Deepa Subramanian, Divya Krishnamoorthi, Gowtham Kannan, Benedict Mathews Paul   +3 more
wiley   +1 more source

Cathepsin L in cancer: Context‐dependent functions, microenvironmental regulation and translational opportunities

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Cathepsin L (CTSL) acts as a context‐dependent facilitator of tumour progression rather than a universal oncogenic driver. CTSL's pro‐tumorigenic functions are critically evaluated alongside its inherent biochemical constraints and family‐wide redundancy. CTSL‐related biology may provide translational opportunities in selected contexts.
Yujun Wu, Qin Huang, Zixuan Ding, Lin Fu, Mu Yang, Bi Peng, Pengbo Hu, Yuanhui Liu   +7 more
wiley   +1 more source

Population‐Based Prediction Equations for Appendicular Skeletal Muscle Mass: A Three‐Phase Validation Study in 13 582 Asian Adults

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Accurate estimation of appendicular skeletal muscle mass (ASM) is crucial for sarcopenia diagnosis, but device‐dependent approaches (dual‐energy X‐ray absorptiometry [DXA] or bioelectrical impedance analysis [BIA]) limit widespread application in community settings.
Hsi‐Yu Lai, Shu Zhang, I‐Tzu Chen, Rei Otsuka, Wei‐Ju Lee, Chih‐Kuang Liang, Ko‐Han Yen, Hidenori Arai, Fei‐Yuan Hsiao, Liang‐Kung Chen   +9 more
wiley   +1 more source

Appendicular Skeletal Muscle Mass and Sarcopenia as Prognostic Markers in Amyotrophic Lateral Sclerosis

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Amyotrophic lateral sclerosis (ALS) is characterized by progressive muscle wasting and functional decline. Prognostic assessment in clinical practice relies largely on functional scales and traditional anthropometric measures. The prognostic relevance of muscle mass, muscle strength and sarcopenia in ALS remains incompletely defined.
María Teresa Zarco‐Martín, María Carmen Andreo‐López, Miriam Soraya Yagui‐Beltrán, María Luisa Fernández‐Soto   +3 more
wiley   +1 more source

Medication Effects on Cystatin C and the Interpretation of Kidney Function: Imperfect but Informative. [PDF]

J Am Soc Nephrol
Barreto EF, Williams VL.
europepmc   +1 more source

Denosumab Versus Zoledronic Acid for Muscle Strength and Physical Performance in Postmenopausal Osteoporosis: A 3‐Year Prospective Study

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Osteoporosis and sarcopenia frequently coexist in older adults, yet whether denosumab provides muscle‐related benefits beyond bone remains uncertain. We compared denosumab and zoledronic acid across functional, imaging, biologic and study‐defined sarcopenia outcomes based on an Asian Working Group for Sarcopenia (AWGS) 2025‐informed
Xiangwen Li, Zineng Yuan, Nina Ma, Bijuan Huang, Hongyue Tao, Shuang Chen   +5 more
wiley   +1 more source

A Multicenter, Open‐Label, Phase 2 Trial Comparing Crizanlizumab Combined With Standard Therapy to Standard Therapy Alone on Renal Function in Patients With Sickle Cell Nephropathy (STEADFAST)

American Journal of Hematology, Volume 101, Issue 10, Page 2666-2671, October 2026.
Kenneth I. Ataga, Pablo Bartolucci, Santosh L. Saraf, Vimal K. Derebail, Adlette Inati, Jeffrey D. Lebensburger, Laurie DeBonnett, Rodolfo D. Cancado, Claire C. Sharpe   +8 more
wiley   +1 more source