Results 121 to 130 of about 33,345 (227)

Calcium Beta‐Hydroxy‐Beta‐Methylbutyrate‐Enriched Nutritional Supplementation During Dietary Weight Loss in Adults With Obesity: A Randomized Controlled Trial

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Dietary and pharmacologic weight loss can reduce skeletal muscle. Whether calcium beta‐hydroxy‐beta‐methylbutyrate (CaHMB)‐enriched supplementation preserves muscle while promoting fat loss in adults with obesity remains uncertain. We evaluated a CaHMB‐enriched nutritional supplement during energy restriction.
Jiaojiao Jiang, Yuxiang Liang, Renjie Wang, Wenhua Jiang, Xiaofan Jing, Ming Yang   +5 more
wiley   +1 more source

Adipose Reserves and Survival: Protective in Prefrail but Ineffective in Frail Oldest‐Old

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background and Aim Among the oldest‐old, the impact of body composition on survival outcomes exhibits pronounced heterogeneity. Although the obesity paradox has been widely discussed, clear evidence is still lacking regarding whether the biological effects of adipose reserves are modulated by functional status.
Jin Yan, Ming Zhao, Cheng Qin, Zhihui Zhu, Ning Di, Bingjie Lu, Cunmei Yang, Qiuli Xu, Zheng Liu, Li Fan, Yixin Hu   +10 more
wiley   +1 more source

Cystatin-C [PDF]

, 2020
openaire   +1 more source

Divergent Atrial Transcriptomic Signatures in Diabetic and Nondiabetic Atrial Fibrillation

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
Diabetes alters the atrial transcriptome in atrial fibrillation, characterized by enhanced mitochondrial ATP synthesis, suppressed immune and inflammatory pathways, and distinct miRNA expression profiles, suggesting metabolic and epigenetic remodeling of the atrial substrate.
Kenshi Yoshimura, Yuya Kiriake, Hiroki Osanai, Mengyan Wei, Shinichiro Kume, Tatsuki Kurokawa, Masaki Morishima, Ryusuke Suzuki, Shinji Miyamoto, Katsushige Ono   +9 more
wiley   +1 more source

Embryonic Mediators of Embryo–Uterus Communication, Implantation and Pregnancy

Molecular Reproduction and Development, Volume 93, Issue 8, August 2026.
ABSTRACT Successful reproduction in eutherian mammals requires intimate connections between the embryo and uterus, involving adhesion, attachment and placentation, with or without invasion of the endometrium. The complex dialogue between embryo and uterus involves numerous molecules and pathways.
Keith E. Latham
wiley   +1 more source

Population Pharmacokinetic and Exposure‐Response Analysis of Vancomycin Nephrotoxicity in Cystic Fibrosis Patients

Pediatric Pulmonology, Volume 61, Issue 8, August 2026.
ABSTRACT Introduction Acute pulmonary exacerbations (APE) in persons with cystic fibrosis (PwCF) are associated with a reduction in long‐term pulmonary function. Vancomycin is recommended as first‐line treatment of methicillin‐resistant Staphylococcus aureus ‐APE in PwCF.
Jessica Barry, J. G. C. van Hasselt, Michael Evans, Elizabeth B. Hirsch, Jordan Dunitz, Sarah Shockley, Joanne Billings, Sílvia M. Illamola   +7 more
wiley   +1 more source

A Systems Pharmacology Model of Aging Identifies Optimal Combination Therapies With Secondary Benefits on Weight Loss and Metabolic Health

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT Aging is a systems‐level process linking metabolic dysfunction, inflammation, impaired repair, frailty, and multimorbidity, whereas existing pharmacological strategies usually optimize disease‐specific endpoints such as weight loss or HbA1c rather than aging‐related trajectories. We developed an SBML‐compliant quantitative systems pharmacology
Igor Goryanin, Bob Damms, Irina Goryanin
wiley   +1 more source

Basement membrane remodeling with fibroblast activation and cystatin C aggregation in cerebral vessels of hereditary cystatin C amyloid angiopathy. [PDF]

Acta Neuropathol Commun
Snorradottir AO, Hafsteinsson HK, Hansdottir K, Ingthorsson S, Gudmundsson SR, Skodras A, Isaksson HJ, Hakonarson H.   +7 more
europepmc   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, Volume 40, Issue 8, Page 4759-4791, August 2026.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Cystatin C Confirms the Canagliflozin eGFR Slope Benefit in CANPIONE. [PDF]

Kidney Int Rep
Miyamoto S, Heerspink HJL, de Zeeuw D, Sakamoto K, Yoshida M, Toyoda M, Suzuki D, Hatanaka T, Nakamura T, Kamei S, Murao S, Hida K, Ando S, Akai H, Takahashi Y, Kitada M, Sugano H, Nunoue T, Nakamura A, Sasaki M, Nakatou T, Fujimoto K, Kawanami D, Wada T, Miyatake N, Kuramoto H, Shikata K.   +26 more
europepmc   +1 more source