Results 161 to 170 of about 11,945 (263)

Nephrocast‐V: A Deep Learning Model for the Prediction of Vancomycin Trough Concentration Using Electronic Health Record Data

open access: yesPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 1, January 2026.
ABSTRACT Introduction Vancomycin is a critical antibiotic for treating methicillin‐resistant Staphylococcus aureus and other gram‐positive bacterial infections, but achieving and maintaining therapeutic trough concentrations is challenging. Objectives We hypothesized that a deep learning model could accurately predict vancomycin trough concentrations 2 
Ghodsieh Ghanbari   +5 more
wiley   +1 more source

Hyperfiltration and Metabolism Before and After a Low‐Calorie, Pre‐Gastric Bypass Surgery Diet: Significance for Concentrations of Hydrophilic and Lipophilic Drugs

open access: yesBasic &Clinical Pharmacology &Toxicology, Volume 138, Issue 1, January 2026.
ABSTRACT Psychotropic drug concentrations increase/decrease with hydrophilicity/lipophilicity after a low‐calorie pre‐bariatric surgery diet. To investigate underlying mechanisms, body weight and serum creatinine/cystatin C changes over the diet period were characterized and suggested to reflect changes in glomerular filtration and metabolic capacity ...
Magnus A. B. Axelsson   +1 more
wiley   +1 more source

Analysis of Current Industry Practices for Informing Dosing Recommendation for Patients With Renal Impairment

open access: yesClinical and Translational Science, Volume 19, Issue 1, January 2026.
ABSTRACT Recent updates in clinical guidelines and health authority guidance documents have aimed to standardize best practices for assessing renal function; however, it remains unclear whether the pharmaceutical industry has fully adopted these recommendations.
Noah Christopher Frazier   +2 more
wiley   +1 more source

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