Results 201 to 210 of about 827,600 (338)

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Hypothesis: Taurine therapy of nephropathic cystinosis may correct the deficiencies of cysteamine therapy. [PDF]

Mol Genet Metab Rep
Thoene JG.
europepmc   +1 more source

Further Observations on Factors Affecting L-Cysteine Desulfhydrase Activity in Chick Liver [PDF]

, 1959
M.N.D. Goswami, Alex R. Robblee, L. W. McElroy   +2 more
openalex   +1 more source

Rational Design of Inner Ear Drug Delivery Systems

Advanced Science, EarlyView.
Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu, Zhiyan Xuan, Haoyu Ren, Keng Chen, Hui Zhang, Huan Wang   +5 more
wiley   +1 more source

Oxidative stress-induced CDO1 glutathionylation regulates cysteine metabolism and sustains redox homeostasis under ionizing radiation. [PDF]

Redox Biol
He Y, Li D, Ye H, Zhu J, Chen Q, Liu R.
europepmc   +1 more source

Inhibition of RACK1‐Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Schematic diagram showing the potential mechanism of bigelovin on the activation of NLRP3 inflammasome Bigelovin may inhibit activated protein C kinase 1 (RACK1) by directly binding with cys168 of RACK1. Bigelovin thus prevents oligomerization of NLRP3 (NLRP3 active conformation) and subsequent assembly of NLRP3 inflammasome, blocking the activation of
Jian Cui, Meng Yang, Chengli Yu, Haidong Zhang, Yuan Gong, Yang Hu, Yue Wang, Qingxin Yuan, An Pan, Jiepin Li, Yaowen Hu, Zecheng Jin, Xuemei Peng, Anyuan Wu, Junwei Wang, Qian Wang, Yinan Zhang, Lihong Hu   +17 more
wiley   +1 more source

Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread

Cell Reports
Summary: The inherent ability of melanoma cells to alter the differentiation-associated transcriptional repertoire to evade treatment and facilitate metastatic spread is well accepted and has been termed phenotypic switching. However, how these facets of
Deyang Yu, Jiaxin Liang, Hans R. Widlund, Pere Puigserver   +3 more
doaj  

Induction of a neurotoxin in diatoms by iron limitation via cysteine synthase. [PDF]

Proc Natl Acad Sci U S A
Zheng X, Wu S, Qiu J, Li A, Li L, Yan G, Li M, Meng F, Zhang K, Lin S.   +9 more
europepmc   +1 more source

THE EFFECT OF CYSTEINE, HISTIDINE, AND METHIONINE ON THE PRODUCTION OF POLYCYTHEMIA BY COBALT

, 1948
James M. Orten, Mary C. Bucciero
openalex   +1 more source

Proteomics of disulfide and cysteine oxidoreduction. [PDF]

, 2006
Finnie, Christine, Hägglund, K.P, Maeda, Kenji, Svensson, Birte   +3 more
core   +1 more source