Results 191 to 200 of about 747,792 (297)

Generating Ultra-Fast Protein trans-Splicing of a Cysteine-Less and Semisynthetic Split Intein for Chemical Protein Labeling. [PDF]

Chembiochem
Humberg C, Terhorst TME, Pasch T, Mootz HD.   +3 more
europepmc   +1 more source

Coordination of Cyanobacterial Nitrate Assimilation and Photosynthesis by a Novel PsbO‐Interacting Protein PirN

Advanced Science, EarlyView.
PirN was identified as a previously uncharacterized PsbO‐interacting protein specifically induced in nitrate‐grown cyanobacteria. Loss of PirN leads to coordinated downregulation of PsbO and the nitrate reductase NarB, causing decreased PSII activity and impaired growth under nitrate conditions. Complementation with either PsbO or NarB largely restores
Chengcheng Huang, Zhen Xiao, Haitao Ge, Gaojie Wang, Jinghui Dong, Yan Wang, Hang Yang, Xing Wang, Hui Gao, Zhongshu Wang, Huanling Yang, Yuanya Zhang, Xiahe Huang, Wu Xu, Weimin Ma, Wenqiang Yang, Yingchun Wang   +16 more
wiley   +1 more source

Enzymes that generate and regulate intracellular persulfides and polysulfides: mechanistic insights and inhibitors. [PDF]

Front Physiol
Hirabayashi K, Sasaki E, Ohno H, Takayama O, Yamada S, Hanaoka K.   +5 more
europepmc   +1 more source

Antagonistic Ubiquitin Switching by USP7 and RNF40 Orchestrates KDM6A Homeostasis to License Coronavirus Susceptibility

Advanced Science, EarlyView.
We identify an antagonistic ubiquitin circuit that controls cellular permissiveness to multiple coronaviruses. The deubiquitinase USP7 stabilizes the epigenetic regulator KDM6A to upregulate viral receptors, while the E3 ligase RNF40 degrades KDM6A by catalyzing K6/K11‐ubiquitin chains of KDM6A for autophagic degradation.
Meng‐Zhuo Huang, Zhong‐Yuan Yang, Shi Wang, Yan Ge, Lan Lin, Mia Madel Alfajaro, Renata B. Filler, Wan‐Yao Song, Ming‐Zhu Kong, Jin Wei   +9 more
wiley   +1 more source

From Covalent Traps to Fluorescent Beacons: The Expanding Arsenal of Chemical Probes for Studying Ubiquitin and Ubiquitin-Like Proteins. [PDF]

Angew Chem Int Ed Engl
Chanda S, Liu WR.
europepmc   +1 more source

High‐Content SRS Imaging Unveils Altered Cholesterol Metabolism in Ovarian Cancers Under CAR‐T Treatment

Advanced Science, EarlyView.
High‐content Stimulated Raman Scattering (SRS) Imaging reveals that ovarian cancer cells surviving Chimeric Antigen Receptor (CAR) ‐T cell challenge exhibit increased cholesterol esterification. Pharmacological inhibition of this pathway with Avasimibe significantly enhances CAR‐T induced killing of ovarian cancer cells by reducing cancer cell ...
Chinmayee V. Prabhu Dessai, Zhuoying Huang, Haonan Lin, Guangrui Ding, Hongjian He, Menna Siddiqui, Meng Zhang, Wilson Wong, Ji‐Xin Cheng   +8 more
wiley   +1 more source

Cysteine Reactivity Profiling Identifies Host Regulators of <i>Mycobacterium tuberculosis</i> Replication in Human Macrophages. [PDF]

ACS Infect Dis
Neff JK, DeMeester KE, Párraga Solórzano PK, Suciu RM, Dix MM, Simon G, Gianakopoulos MA, Melillo B, Cravatt BF, Shiloh MU.   +9 more
europepmc   +1 more source

Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling

Proceedings of the National Academy of Sciences of the United States of America, 2014
T. Ida, T. Sawa, H. Ihara, Yukihiro Tsuchiya, Yasuo Watanabe, Y. Kumagai, M. Suematsu, H. Motohashi, Shigemoto Fujii, Tetsuro Matsunaga, Masayuki Yamamoto, K. Ono, N. Devarie-Baez, M. Xian, J. Fukuto, T. Akaike   +15 more
semanticscholar   +1 more source

Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes

Advanced Science, EarlyView.
This review synthesizes advances in bone organoid engineering and evaluates their potential to model diabetic bone fragility. Current in vitro and animal models do not fully recapitulate diabetes‐associated skeletal phenotypes. Cell‐based and scaffold‐based bone organoids are discussed as complementary approaches to reconstruct multicellular bone ...
Shuangzhe Lin, Karthikeyan Narayanan, Deepak Vashishth   +2 more
wiley   +1 more source

DMNQ induces ferroptosis and augments the efficacy of anti-PD-L1 immunotherapy in gastric cancer via the STAT3/SLC1A4 axis to mediate cysteine metabolism reprogramming. [PDF]

Redox Biol
Zhu W, Qi H, Jing F, Shi Y, Xing Y, Ma X, Ning B, Wang Y, Jia Y.   +8 more
europepmc   +1 more source