Results 171 to 180 of about 654,528 (315)

Serum thiol redox-related alterations in asymptomatic first-degree relatives are associated with future Crohn's disease. [PDF]

Redox Biol
Mu K, Xue M, Huynh HQ, Griffiths AM, Turner D, Moayyedi P, Steinhart AH, Dieleman LA, Deslandres C, Bitton A, Mack DR, Jacobson K, Cino M, Aumais G, Panaccione R, Bressler B, Lee SH, Turpin W, Croitoru K, Crohn's and Colitis Canada Genetics Environment Microbial Project Research Consortium.   +19 more
europepmc   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Endogenous hydrogen sulfide reprograms mitochondrial respiration and modulates pathogenicity in <i>Ustilago maydis</i>. [PDF]

Curr Res Microb Sci
Espinoza-Simón E, Torres-Ramírez N, Juárez-Montiel M, Ríos-Castro E, García-Reyes MM, Ramírez-Robles D, Ortíz-Hernández R, Echeverría-Martínez O, Villa-Tanaca L, Torres-Quiroz F.   +9 more
europepmc   +1 more source

Cysteine [PDF]

, 2020
openaire   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

Significance of GSH and H₂S regulation for cancer: an intricate interplay between diet, microbiota, metabolic reprogramming, and immune health. [PDF]

Redox Rep
Majumder A, Majumder S, Bano S, Sen K, Nayak KB.   +4 more
europepmc   +1 more source

Unveiling Lactylation: A Novel Frontier in Cancer Stemness and Therapy

Advanced Science, EarlyView.
Tumor metabolism and epigenetic regulation are intrinsically linked. This review highlights lactylation as a pivotal bridge connecting these processes, acting as an active epigenetic effector in cancer stemness. We delineate how lactylation orchestrates the cancer stem cell landscape and evaluate its regulatory networks.
Ting Li, Hongyu Gu, Chang Liu, Yuesheng Lv, Feifei Li, Liang Liang, Jia Yi, Xuanyi Wang, Yi Zhun Zhu, Chuan Xu   +9 more
wiley   +1 more source

Beyond Hydrogen Sulfide and Cysteine Metabolism: Reframing Cystathionine γ-Lyase as a Potential Translational Regulator of Hypoxia-Inducible Factor-1α in Clear Cell Ovarian Carcinoma. [PDF]

Cells
El-Naggar AM.
europepmc   +1 more source

Two Routes to Land: Genomic Underpinnings of Parallel Aerial Egg Deposition in Aquatic Old‐World Pila and New‐World Pomacea (Ampullariidae)

Advanced Science, EarlyView.
Comparative genomics of Gondwana‐diverged Pila and Pomacea reveals parallel evolution of aerial oviposition. Convergent chromosomal rearrangements reshape regulatory landscapes within topologically associating domains. Lineage‐specific gene family expansions and viral‐derived perivitelline proteins (PV1) underpin desiccation resistance.
Yufei Zhou, Huawei Mu, Xueying Nie, Yue Gao, Hui Wang, Ling Fang, Tiangang Luan, Monthon Ganmanee, Jian‐Wen Qiu, Jin Sun, Jack Chi‐Ho Ip   +10 more
wiley   +1 more source

The cysteine metabolic regulation through CSE-transsulfuration pathway is essential in iron-induced oxidative damage of heart. [PDF]

Redox Rep
Zhang Y, Xin Y, Zhou J, Yang G, Li S.
europepmc   +1 more source