Plasma Proteomic Signature as a Predictor of Age Advancement in People Living With HIV
We developed a prediction model of biological age based on 77 plasma proteins that were associated with chronological age in two independent cohorts of PLHIV and one cohort of people without HIV. PLHIV exhibited an increased age advancement that was positively associated with previous co‐infections and non‐AIDS‐related comorbidities, a higher ...
Adriana Navas+10 more
wiley +1 more source
Comparison of Two Cysteine Endopeptidases from Latices of Morrenia brachystephana Griseb. and Morrenia odorata (Hook et Arn.) Lindley (Asclepiadaceae) [PDF]
Sandra Vairo Cavalli+5 more
openalex +2 more sources
Salivary Proteomics for Detecting Novel Biomarkers of Periodontitis: A Systematic Review
Untargeted salivary proteomics identified promising biological molecules consistently over‐ or under‐expressed in periodontitis patients compared to periodontally healthy subjects, but further targeted approaches are required for their validation. ABSTRACT Aim Salivary content is regarded as a powerful diagnostic window for oral and systemic diseases ...
Matteo Corana+7 more
wiley +1 more source
Salmonella chemoreceptors McpB and McpC mediate a repellent response to L-cystine: a potential mechanism to avoid oxidative conditions [PDF]
Chemoreceptors McpB and McpC in Salmonella enterica have been reported to promote chemotaxis in LB motility-plate assays. Of the chemicals tested as potential effectors of these receptors, the only response was towards L-cysteine and its oxidized form, L-cystine.
arxiv
Tandem duplications and the limits of natural selection in Drosophila yakuba and Drosophila simulans [PDF]
Tandem duplications are an essential source of genetic novelty, and their variation in natural populations is expected to influence adaptive walks. Here, we describe evolutionary impacts of recently-derived, segregating tandem duplications in Drosophila yakuba and Drosophila simulans. We observe an excess of duplicated genes involved in defense against
arxiv +1 more source
Maternal haploid induction in maize via mutation of Gamete Expression protein 1
Summary Doubled haploid (DH) technology, based on haploid induction (HI), is a crucial tool in enhancing crop‐breeding efficiency and has been successfully applied in various plant species. While many HI‐related genes have been identified using diverse strategies, the genetic basis and molecular mechanisms underlying HI remain incompletely understood ...
Yuhui Sun+5 more
wiley +1 more source
Molecular Dynamics Study of Transport Properties of Cysteine in Water [PDF]
Molecular dynamics simulation is a prominent way of analyzing the dynamic properties of a system. The molecular dynamics simulation of diffusion, an important transport property, of dilute solution of cysteine in SPCE water at five different temperatures (288 K, 293 K, 303 K, 313 K, 323 K) under the pressure of 1 bar is studied using GROMACS.
arxiv
Abstract Although seed represents an important means of plant pathogen dispersion, the seed–pathogen dialogue remains largely unexplored. A multiomic approach was performed at different seed developmental stages of common bean (Phaseolus vulgaris L.) during asymptomatic colonization by Xanthomonas citri pv.
Armelle Darrasse+6 more
wiley +1 more source
Spectroscopy, Dynamics and Hydration of S-Nitrosylated Myoglobin [PDF]
S-nitrosylation, the covalent addition of NO to the thiol side chain of cysteine, is an important post-transitional modification that can alter the function of various proteins. The structural dynamics and vibrational spectroscopy of S-nitrosylation in the condensed phase is investigated for the methyl-capped cysteine model system and for myoglobin ...
arxiv
Main Points Generation and characterization of iPSC‐derived astrocytes from 44 aged humans. Congruence of gene expression profiles between astrocyte cultures and brain. Association of interferon response proteins with AD pathology resilience. ABSTRACT Reactive astrocytes are associated with Alzheimer's disease (AD), and several AD genetic risk variants
Hyo Lee+16 more
wiley +1 more source