A cysteine protease inhibitor GC376 displays potent antiviral activity against coxsackievirus infection [PDF]
Current Research in Microbial Sciences, 2023 Infection with coxsackievirus A10 (CV-A10) can cause hand-foot-mouth disease and is also associated with severe complications, including viral pneumonia, aseptic and viral meningitis.
Yongkang Chen +8 more
doaj +3 more sources
Falstatin, a cysteine protease inhibitor of Plasmodium falciparum, facilitates erythrocyte invasion. [PDF]
PLoS Pathogens, 2006 Erythrocytic malaria parasites utilize proteases for a number of cellular processes, including hydrolysis of hemoglobin, rupture of erythrocytes by mature schizonts, and subsequent invasion of erythrocytes by free merozoites.
Kailash C Pandey +4 more
doaj +3 more sources
Purification and characterization of cysteine protease of Sarcocystis fusiformis from infected Egyptian water buffaloes [PDF]
Scientific Reports, 2023 Sarcocystis spp. infects water buffaloes (Bubalus bubalis) causing sarcocystosis. In the present study, Sarcocystis fusiformis was recognized in Egyptian water buffaloes based on histological observation and molecular analysis of internal transcribed ...
Amal Z. Barakat +8 more
doaj +2 more sources
In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. [PDF]
PLoS Neglected Tropical Diseases, 2010 Cruzain, the major cysteine protease of Trypanosoma cruzi, is an essential enzyme for the parasite life cycle and has been validated as a viable target to treat Chagas' disease.
Yen Ting Chen +6 more
doaj +6 more sources
NbPIRIN promotes the protease activity of papain-like cysteine protease NbRD21 to inhibit Chinese wheat mosaic virus infection. [PDF]
PLoS PathogensPapain-like cysteine proteases (PLCPs) play critical roles in regulating plant immunity against a range of pathogens and a series of cysteine protease inhibitors have been identified, however, relatively little research has been done on proteins that ...
Kaili Zhong +8 more
doaj +2 more sources
Proteolytic Activity Inhibition in Gingival Fluid by Cysteine Protease Inhibitors Obtained from Egg White and Fallopia japonica Extract: An In Vitro Study [PDF]
BiomedicinesBackground/Objectives: Gingipains produced by P. gingivalis have been shown to be directly related to periodontal tissue degradation and are significant molecular targets in therapy of periodontitis.
Maciej Siewiński +12 more
doaj +2 more sources
Screening of Covalent Kinase Inhibitors Yields Hits for Cysteine Protease USP7 / HAUSP. [PDF]
Drug Des Devel TherErnst LN +11 more
europepmc +2 more sources
Determination the binding ability of N-acetyl cysteine and its derivatives with SARS-COV-2 main protease using molecular docking and molecular dynamics studies [PDF]
The Ukrainian Biochemical Journal, 2021 N-acetyl cysteine (NAC) drug has been used as an antioxidant and anti-inflammatory agent in clinical practice and more recently in the treatment of COVID-19 patients.
A. H. Shntaif +3 more
doaj +1 more source
Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor. [PDF]
PLoS Medicine, 2007 Schistosomiasis is a chronic, debilitating parasitic disease infecting more than 200 million people and is second only to malaria in terms of public health importance.
Maha-Hamadien Abdulla +4 more
doaj +1 more source
Frontiers in Plant Science, 2022 The hypersensitive response is elicited by Agrobacterium infiltration of Nicotiana benthamiana, including the induction and accumulation of pathogenesis-related proteins, such as proteases.
Advaita Acarya Singh +10 more
doaj +1 more source