Results 131 to 140 of about 260,155 (239)
Advanced Science, EarlyView.These findings elucidate the innovative role of HIC1 as a transcriptional activator in GC, driving the initiation of pyroptosis and enhancing CD8+ T cell infiltration, which has certain novelty and creative significance. Collectively, targeting HIC1 can present an appealing immunotherapeutic strategy to improve outcomes in GC patients.
Mengjie Kang +4 more
wiley +1 more source
Effects of cysteine on growth, protease production, and catalase activity of Pseudomonas fluorescens [PDF]
, 1986 Brian Himelbloom, Hosni M. Hassan
openalex +1 more source
Macrophage HM13/SPP Enhances Foamy Macrophage Formation and Atherogenesis
Advanced Science, EarlyView.Previous research suggests that AIP may prevent atherogenic foamy macrophage formation. This study reveals that AIP, via its chaperone interaction with AHR, inhibits p38‐c‐JUN‐mediated transactivation of HM13, which encodes the ERAD protease HM13/SPP. HM13/SPP promotes foamy macrophage formation in addition to atherogenesis and plaque foamy macrophage ...
Yu Cao +15 more
wiley +1 more source
On the stability of tetrahedral intermediates within the active sites of serine and cysteine proteases [PDF]
, 1983 Jacques Fastrez
openalex +1 more source
Advanced Science, EarlyView.This study investigates the metabolic vulnerabilities of glioblastoma (GBM), an aggressive brain tumor. Research demonstrates that iron chelation therapy, in combination with standard chemotherapy, significantly enhances the efficacy of treatment against resistant GBM cells in a 3D tumoroid model.
Meitham Amereh +8 more
wiley +1 more source
Import of apocytochrome c into the mitochondrial intermembrane space along a cytochrome c1 sorting pathway [PDF]
, 1990 The question of whether cytochrome c could be functionally sorted to the mitochondrial intermembrane space along a "conservative sorting" pathway was investigated using a fusion protein termed pLc1-c. pLc1-c contains 3-fold targeting information, namely,
Neupert, Walter +3 more
core
Advanced Science, EarlyView.As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang +10 more
wiley +1 more source
Expression and alteration of the S2 subsite of the Leishmania major cathepsin B-like cysteine protease [PDF]
, 1999 Victor J. Chan +3 more
openalex +2 more sources
Advanced Science, EarlyView.Here gelatinase‐responsive methoxypolyethyleneglycol–PVGLIG–polycaprolactone (mPEG–PVGLIG–PCL) nanoparticles’ loading verteporfin (N@VP) is developed, enhancing radiotherapy via X‐ray‐triggered singlet oxygen generation. Combined with 2 Gy (gray, a radiation dose unit) irradiation, N@VP achieves antitumor efficacy comparable to 8 Gy, and also promotes ...
Zhifan Zhang +16 more
wiley +1 more source
Salmonella chemoreceptors McpB and McpC mediate a repellent response to L-cystine: a potential mechanism to avoid oxidative conditions [PDF]
Lazova, M. D., Butler, M. T., Shimizu, T. S., and Harshey, R. M.,
Salmonella chemoreceptors McpB and McpC mediate a repellent response to
L-cystine: a potential mechanism to avoid oxidative conditions. Mol Microbiol
84 (4), 697 (2012), 2013 Chemoreceptors McpB and McpC in Salmonella enterica have been reported to promote chemotaxis in LB motility-plate assays. Of the chemicals tested as potential effectors of these receptors, the only response was towards L-cysteine and its oxidized form, L-cystine.
arxiv