Results 181 to 190 of about 313,172 (330)

The cysteine-rich domain regulates ADAM protease function in vivo [PDF]

, 2002
Katherine Smith, Alban Gaultier, Hélène Cousin, Dominique Alfandari, Judith M. White, Douglas W. DeSimone   +5 more
openalex   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Acanthamoeba castellanii cysteine protease 3 promotes M1 macrophage polarization through the TLR4/NF‑κB pathway. [PDF]

Parasit Vectors
Wang ZX, Jiao WJ, Wang MJ, Yang Y, Wang HL, Liu HL.   +5 more
europepmc   +1 more source

Cysteine Proteases

, 2007
Grzonka, Zbigniew, Kasprzykowski, Franciszek, Wiczk, WiesŁaw   +2 more
openaire   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Evaluating the protonation state of the catalytic Cys25 in cruzain cysteine protease: A target for Chagas disease. [PDF]

Protein Sci
da Costa CHS, Bonatto V, Santos HBT, Souza CGDS, Montanari CA, Skaf MS, Luque FJ, Lameira J.   +7 more
europepmc   +1 more source

Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine

, 2022
Kaitlin R. Hulce, Priyadarshini Jaishankar, Gregory M. Lee, Markus‐Frederik Bohn, Emily J. Connelly, Kristin Wucherer, Chayanid Ongpipattanakul, Regan Volk, Shih‐Wei Chuo, Michelle R. Arkin, Adam R. Renslo, Charles S. Craik   +11 more
openalex   +1 more source

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Advanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li‐Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang   +29 more
wiley   +1 more source

The diagnostic value of serum cysteine protease inhibitor (CST4) in colorectal cancer: a preliminary study. [PDF]

BMC Gastroenterol
Lan Y, Zhang L, Li R.
europepmc   +1 more source

SIGNIFICANCE OF CIRCULATING CYSTEINE-DEPENDENT ASPARTATE-DIRECTED PROTEASE-1 (CASPASE-1) IN PERITONITIS

, 2021
Mihail Virgil Boldeanu, Lidia Boldeanu, Isabela Siloşi   +2 more
openalex   +1 more source