Results 281 to 290 of about 313,172 (330)

The Power of Molecular Dynamics Simulations and Their Applications to Discover Cysteine Protease Inhibitors. [PDF]

Mini Rev Med Chem
Dos Santos Nascimento IJ, Gomes JNS, de Oliveira Viana J, de Medeiros E Silva YMS, Barbosa EG, de Moura RO.   +5 more
europepmc   +1 more source

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, EarlyView.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Design, synthesis and biological activity of peptidyl β-nitrostyrenes as cysteine protease inhibitors against Leishmania donovani. [PDF]

RSC Adv
Sharma S, Beg MA, Latief I, Aboti J, Jamal S, Juneja P, Tanwar S, Sharma K, Rehman SU, Selvapandiyan A, Shafi S.   +10 more
europepmc   +1 more source

EGR1 Nuclear Condensates Promote Renal Cyst Development in Polycystic Kidney Disease

Exploration, EarlyView.
ABSTRACT Autosomal dominant polycystic kidney disease (ADPKD) is marked by aberrant cell proliferation driven by cAMP‐PKA and MAPK signaling pathways. EGR1, a transcription factor directly activated by the above two pathways, is critical in the over‐proliferation of tumor cells, which share similarities with cystic epithelial cells in ADPKD. This study
Chaoqun Ren, Zhaoxu Wu, Min Li, Yaqin Du, Hong Zhou, Yazhu Quan, Mengyao Xiong, Yiming Wang, Zhiwei Qiu, Shuai Zhu, Xiaowei Li, Jinzhao He, Cai Gao, Hui Cai, Tingting Li, Baoxue Yang   +15 more
wiley   +1 more source

Development of a new experimental NMR strategy for covalent cysteine protease inhibitors screening: toward enhanced drug discovery. [PDF]

RSC Adv
Chihab A, El Brahmi N, Hamdoun G, El Abbouchi A, Ghammaz H, Touil N, Bousmina M, El Fahime E, El Kazzouli S.   +8 more
europepmc   +1 more source

Integrated In Vitro, In Vivo, and In Silico Study Reveals Gut‐Protective Effects of Myricitrin From Chinese Bayberry Leaves

Food Frontiers, EarlyView.
High‐purity myricitrin from Chinese bayberry leaves alleviates colonic inflammation by preserving epithelial barrier integrity and reshaping gut microbiota composition. ABSTRACT Polyphenols have been widely recognized for their ability to modulate the host inflammatory response and orchestrate the intestinal microenvironment.
Ji‐Min Lv, Wei Quan, Xiao‐Hua Cheng, Jing Zhu, Aliyu Idris Muhammad, Wang‐Ting Zhou, Xing‐Jiang Qi, Chong‐De Sun   +7 more
wiley   +1 more source

Tick cysteine protease inhibitors suppress immune responses in mannan-induced psoriasis-like inflammation. [PDF]

Front Immunol
Wu H, Jmel MA, Chai J, Tian M, Xu X, Hui Y, Nandakumar KS, Kotsyfakis M.   +7 more
europepmc   +1 more source

Protein Energy Malnutrition: Opportunities for Cold Plasma Technologies

Food Frontiers, EarlyView.
Protein energy malnutrition (PEM) is a major global health concern driven by biological, environmental, and nutritional factors, including gut microbiota imbalance and low protein intake. Cold atmospheric plasma technologies offer promising, sustainable solutions by improving food security, enhancing protein quality and absorption, and modulating gut ...
Karthika Prasad, Syamlal Sasi, Nina Recek, Janith Weerasinghe, Elena P. Ivanova, Igor Levchenko, Katia Alexander   +6 more
wiley   +1 more source

Ribosomal-processing cysteine protease homolog modulates <i>Streptococcus mutans</i> glucan production and interkingdom interactions. [PDF]

J Bacteriol
Treerat P, de Mattos C, Burnside M, Zhang H, Zhu Y, Zou Z, Anderson D, Wu H, Merritt J, Kreth J.   +9 more
europepmc   +1 more source

Understanding protein–flavor interactions: Factors, characterization techniques, and the effect of processing

Food Biomacromolecules, EarlyView.
Abstract The perception of flavor in a food system depends on its release from the protein matrix. Apart from hydrogen bonding, hydrophobic interactions and van der Waal's forces, the formation of covalent adducts between the flavor and protein highly impacts the release of flavor from the protein matrix.
Arshita Verma, Somnath Basak, Rekha S. Singhal   +2 more
wiley   +1 more source