The Shigella Spp. Type III Effector Protein OspB Is a Cysteine Protease
mBio, 2022 The type III secretion system is required for virulence of many pathogenic bacteria. Bacterial effector proteins delivered into target host cells by this system modulate host signaling pathways and processes in a manner that promotes infection.
Thomas E. Wood +8 more
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XCP1 cleaves Pathogenesis-related protein 1 into CAPE9 for systemic immunity in Arabidopsis
Nature Communications, 2023 Proteolytic activation of cytokines regulates immunity in diverse organisms. In animals, cysteine-dependent aspartate-specific proteases (caspases) play central roles in cytokine maturation.
Ying-Lan Chen +6 more
doaj +1 more source
Folding of a single domain protein entering the endoplasmic reticulum precedes disulfide formation [PDF]
, 2017 The relationship between protein synthesis, folding and disulfide formation within the endoplasmic reticulum (ER) is poorly understood. Previous studies have suggested pre-existing disulfide links are absolutely required to allow protein folding and ...
Bulleid, Neil J. +3 more
core +1 more source
Cathepsin Release from Lysosomes Promotes Endocytosis of Clostridium perfringens Iota-Toxin
Toxins, 2021 Iota-toxin from Clostridium perfringens type E is a binary toxin composed of two independent proteins: actin-ADP-ribosylating enzyme component, iota-a (Ia), and binding component, iota-b (Ib).
Masahiro Nagahama +2 more
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Flowering conditions affect flower longevity in Syringa vulgaris and cause changes in protein content, protease activity and expression of a KDEL-CysEP gene [PDF]
, 2016 Forcing is a method that is usually used to induce flowering in plants, independent of the natural blooming period. The temperatures required to start blooming in lilac in November are ca. 37°C causing degeneration of flowers.
Jędrzejuk, Agata +3 more
core +2 more sources
Status and future directions of anti-metastatic cancer nanomedicines for the inhibition of cathepsin L [PDF]
, 2020 Angiogenesis, tissue invasion and metastasis in the tumour microenvironment are all critical hallmarks of cancer. Upregulation of cathepsin L plays an important role in angiogenesis and metastasis through its ability to degrade the extracellular matrix ...
Pranjol, Md Zahidul I +3 more
core +2 more sources
Molecules, 2014 Extraction of protease from a local ginger rhizome (Zingiber officinale var. Bentong) was carried out. The effect of extraction pH (6.4, 6.8, 7.0, 7.2, 7.6, 8.0, 8.4, and 8.8) and stabilizers (0.2% ascorbic acid, 0.2% ascorbic acid and 5 mM EDTA, or 10 ...
Ahmad Nafi' +3 more
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Novel cruzain inhibitors for the treatment of Chagas' disease. [PDF]
, 2012 The protozoan parasite Trypanosoma cruzi, the etiological agent of Chagas' disease, affects millions of individuals and continues to be an important global health concern.
Arkin, Michelle R +6 more
core +1 more source
Expanding Repertoire of Plant Positive-Strand RNA Virus Proteases
Viruses, 2019 Many plant viruses express their proteins through a polyprotein strategy, requiring the acquisition of protease domains to regulate the release of functional mature proteins and/or intermediate polyproteins.
Krin S. Mann, Hélène Sanfaçon
doaj +1 more source
Structural modeling and functional analysis of the essential ribosomal processing protease Prp from Staphylococcus aureus [PDF]
, 2017 In Firmicutes and related bacteria, ribosomal large subunit protein L27 is encoded with a conserved N-terminal extension that is removed to expose residues critical for ribosome function. Bacteria encoding L27 with this N-terminal extension also encode a
Christie, Gail E. +3 more
core +2 more sources