Results 291 to 300 of about 313,172 (330)

Inhibition of cysteine protease disturbs the topological relationship between bone resorption and formation in vitro. [PDF]

J Bone Miner Metab
Ono S, Tsuji N, Sakamoto T, Oguchi S, Nakamura T, Hoshi K, Hikita A.   +6 more
europepmc   +1 more source

Buck Wheat: Nutritional, Bioactive Characteristics, Health Benefits, and Side Effects

Future Postharvest and Food, EarlyView.
ABSTRACT Micronutrient deficits have resulted from an over‐reliance on a small number of cereal crops for food security. The agricultural sector faces severe sustainability issues due to the rapid growth of the world's population and sudden climatic changes.
Momina Farooq, Sajad Ahmad Mir, Zahida Naseem   +2 more
wiley   +1 more source

Cysteine protease I29 propeptide from Calotropis procera R. Br. As a potent cathepsin L inhibitor and its suppressive activity in breast cancer metastasis. [PDF]

Sci Rep
Kwon YJ, Lee J, Seo EB, Lee J, Park J, Kim SK, Yu H, Ye SK, Chang PS.   +8 more
europepmc   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Silencing Ditylenchus destructor cathepsin L-like cysteine protease has negative pleiotropic effect on nematode ontogenesis. [PDF]

Sci Rep
Huang G, Cong Z, Liu Z, Chen F, Bravo A, Soberón M, Zheng J, Peng D, Sun M.   +8 more
europepmc   +1 more source

Identification of Dihydropyrazolo[1,5-a]pyrazin-4(5H)-ones as Cyclic Products of β-Amidomethyl Vinyl Sulfone Alphavirus Cysteine Protease Inhibitors. [PDF]

Pharmaceuticals (Basel)
Ghoshal A, Magalhães ÁF, Asressu KH, Hossain MA, Todd MH, Willson TM.   +5 more
europepmc   +1 more source

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Inhibitors of Cysteine Proteases

Current Topics in Medicinal Chemistry, 2006
The roles of cysteine proteases (CP) as protein degrading and protein processing enzymes both in physiological and pathological processes of mammals are well known. Furthermore, the key roles of CP;s in the life cycles of infectious agents like protozoa and viruses turn them into new important targets for anti-infective drugs.
Radim, Vicik, Matthias, Busemann, Knut, Baumann, Tanja, Schirmeister   +3 more
openaire   +2 more sources

Inactivation of Cysteine Proteases

Archives of Biochemistry and Biophysics, 1996
The cysteine proteases papain and cathepsin B are inactivated by a Michael acceptor, a peptidyl-beta-chloro-alpha, beta-unsaturated ester (N-Ac-L-Phe-NHCH2-CCl=CH-COOMe). Inactivation occurred concomitant with chloride release which was stoichiometric with the amount of enzyme.
C P, Govardhan, R H, Abeles
openaire   +2 more sources

THE LYSOSOMAL CYSTEINE PROTEASES

Annual Review of Biophysics and Biomolecular Structure, 1999
▪ Abstract  A significant number of exciting papain-like cysteine protease structures have been determined by crystallographic methods over the last several years. This trove of data allows for an analysis of the structural features that empower these molecules as they efficiently carry out their specialized tasks.
openaire   +2 more sources