Results 311 to 320 of about 313,172 (330)
Some of the next articles are maybe not open access.
Lysosomal cysteine proteases regulate antigen presentation
Nature Reviews Immunology, 2003Antigen presentation by both classical MHC class II molecules and the non-classical MHC class I-like molecule CD1D requires their entry into the endosomal/lysosomal compartment. Lysosomal cysteine proteases constitute an important subset of the enzymes that are present in this compartment and, here, we discuss the role of these proteases in regulating ...
Karen, Honey, Alexander Y, Rudensky
openaire +2 more sources
Involvement of Cysteine Proteases in Cancer
Current Medicinal Chemistry, 2015The cysteine protease family members play important roles in various pivotal cellular processes. The difficulty in the analysis of the effects of cysteine protease aberrations in cancer comes as a result of the fact that they take part in complex proteolytic pathways.
Jerzy, Góra, Rafal, Latajka
openaire +2 more sources
Cysteine Protease Zymography: Brief Review
2017Cysteine proteases play multiple roles in basically all aspects of physiology and development. In plants, they are involved in growth and development and in accumulation and mobilization of storage proteins. Furthermore, they are engaged in signalling pathways and in the response to biotic and abiotic stresses.
openaire +2 more sources
Cysteine proteases as disease markers
Clinica Chimica Acta, 2004This review comprises issues concerning cysteine cathepsins (CCs): human peptidases belonging to papain family (C1) of clan CA of cysteine proteases: cathepsins B, L, H, S, K, F, V, X, W, O and C. The involvement of these enzymes in physiological and pathological processes is described, especially with respect to their application as diagnostic and ...
openaire +2 more sources
1998
Abstract Lysosomal cysteine proteinases are proteolytic enzymes with a cysteine residue in the active site, which degrade proteins taken up by the cell or originating in other cell compartments. They catalyze the hydrolysis of peptide, amide, ester, and thiol bonds, dependent on pH and the presence of reducing compounds.
openaire +1 more source
Abstract Lysosomal cysteine proteinases are proteolytic enzymes with a cysteine residue in the active site, which degrade proteins taken up by the cell or originating in other cell compartments. They catalyze the hydrolysis of peptide, amide, ester, and thiol bonds, dependent on pH and the presence of reducing compounds.
openaire +1 more source
Lysosomal Cysteine Proteases and Antigen Presentation
2006Lysosomal proteinases are involved in two critical stages of MHC class II-mediated antigen presentation, i.e., degradation of invariant chain, a chaperone molecule critical for MHC class II assembly and transport, and generation of class II-binding peptides in the endocytic compartment. We found that two lysosomal cysteine proteinases, cathepsins S and
A, Rudensky, C, Beers
openaire +2 more sources
Giardia lamblia cysteine proteases
Parasitology Research, 2006Kelly N, DuBois +4 more
openaire +2 more sources
Cysteine proteases and cysteine protease inhibitors in non-small cell lung cancer.
Neoplasma, 1999In this study we investigated the levels of two lysosomal cysteine protease proteins cathepsin B (CB) and cathepsin L (CL) and the levels of three cysteine protease inhibitor proteins stefin A (SFA), stefin B (SFB) and cystatin C (CNC) in squamous-cell lung carcinoma (SQCLC) and matched lung parenchyma specimens and examined the inhibition of CB and ...
E, Krepela +4 more
openaire +1 more source