Results 71 to 80 of about 260,155 (239)

Covalent Reversible Inhibitors of Cysteine Proteases Containing the Nitrile Warhead: Recent Advancement in the Field of Viral and Parasitic Diseases

Molecules, 2022
In the field of drug discovery, the nitrile group is well represented among drugs and biologically active compounds. It can form both non-covalent and covalent interactions with diverse biological targets, and it is amenable as an electrophilic warhead ...
Simone Brogi, Roberta Ibba, Sara Rossi, Stefania Butini, Vincenzo Calderone, Sandra Gemma, Giuseppe Campiani   +6 more
doaj   +1 more source

Expressed sequence tags from the oomycete fish pathogen Saprolegnia parasitica reveal putative virulence factors [PDF]

, 2005
Peer reviewedPublisher ...
Gajendran, K., Kamoun, S., Tian, M., Torto-Alalibo, T., Van West, Pieter, Waugh, M. E.   +5 more
core   +3 more sources

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

Human glutathione-S-transferase pi potentiates the cysteine-protease activity of the Der p 1 allergen from house dust mite through a cysteine redox mechanism

Redox Biology, 2019
Environmental proteases have been widely associated to the pathogenesis of allergic disorders. Der p 1, a cysteine-protease from house dust mite (HDM) Dermatophagoides pteronyssinus, constitutes one of the most clinically relevant indoor aeroallergens ...
Juan Carlos López-Rodríguez, Juliana Manosalva, J. Daniel Cabrera-García, María M. Escribese, Mayte Villalba, Domingo Barber, Antonio Martínez-Ruiz, Eva Batanero   +7 more
doaj  

The cysteine protease ATG4B of Trichinella spiralis promotes larval invasion into the intestine of the host

Veterinary Research, 2020
The cysteine proteases of parasites are vital contributors that induce parasite migration to and invasion of host tissue. In this study, we analysed the cysteine protease ATG4B of Trichinella spiralis (TsATG4B) isolated from the soluble proteins of ...
Yalan Li, Baiyan Wang, Yaxin Zhu, Zhihua Tian, Zhuo Yang, Jiaqi Duan, Zhongquan Wang   +6 more
doaj   +1 more source

Evidence for the involvement of cysteine proteases in the regulation of methyl jasmonate-induced cell death in grapevine [PDF]

, 2015
A new system to study programmed cell death (PCD) in plants is described. Grapevine (Vitis vinifera L., cv. Limberger) leaves and suspension cells were induced to undergo a form of cell death that mimics the hypersensitive response (HR) by treatment with
Repka, V.
core   +2 more sources

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Efficient Cysteine Conformer Search with Bayesian Optimization [PDF]

arXiv, 2020
Finding low-energy molecular conformers is challenging due to the high dimensionality of the search space and the computational cost of accurate quantum chemical methods for determining conformer structures and energies. Here, we combine active-learning Bayesian optimization (BO) algorithms with quantum chemistry methods to address this challenge ...
arxiv  

Design and Synthesis of Cysteine Protease Inhibitors

Proceedings, 2017
We have been preparing new dipeptidyl inhibitors against parasitic cysteine proteases cruzain (related to Chagas disease) and rhodesain (related to Sleeping Sickness disease), and against human cathepsins. [...]
Florenci V. Gonzalez
doaj   +1 more source