Results 221 to 230 of about 108,777 (376)

Cysteine proteinases and their inhibitors - A traditional topic of the Portoroz conferences [PDF]

, 2001
Fritz, H., Jochum, M.
core   +1 more source

Atlantic salmon (Salmo salar L.) skin contains a novel kininogen and another cysteine proteinase inhibitor [PDF]

, 1999
Anne Ylönen, Ari Rinne, Jukka Herttuainen, Jarl Bøgwald, Mikko Järvinen, Nisse Kalkkinen   +5 more
openalex   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Insights into the complexity of SARS-CoV-2 M^pro inhibition: Ebselen and its derivatives impair dimerisation of the enzyme. [PDF]

J Enzyme Inhib Med Chem
Fabbian S, Fabi S, Schwarz L, Preto G, Schiavinato C, Salata C, Crocetti L, Battistutta R, Gatto B, Sosic A.   +9 more
europepmc   +1 more source

Three dimensional structure of a cysteine proteinase inhibitor, Cystatin A, variant P25S : a role for the Pro residue in the middle of an a helix

, 1999
Nobuhisa Shimba, S. Tate, Eri Kariya, Srinivas Suda, Hiroyuki Kaji, Tatsuya Samejima, Masatsune Kainosho   +6 more
openalex   +2 more sources

The synthesis of peptidylfluoromethanes and their properties as inhibitors of serine proteinases and cysteine proteinases [PDF]

, 1986
P Rauber, Herbert Angliker, Brian Walker, E Shaw   +3 more
openalex   +1 more source

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

Advanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin, Si‐ying He, Ting‐hui Xiao, Da‐mao Dai, Xin‐jia Hu, Nan Jiang   +5 more
wiley   +1 more source

Moringa oleifera potential for the treatment and prevention of COVID-19 involving molecular interaction, antioxidant properties and kinetic mechanism. [PDF]

PLoS One
Hamadou M, Bakwo Bassogog CB, Obadias FV, Assaly AD, Mune Mune MA.   +4 more
europepmc   +1 more source

The crystal structure of a bifunctional Kunitz type cysteine proteinase inhibitor at 1.9 Å resolution [PDF]

, 1996
Mihir Ghosh, M. Mares, Karl Harlos, Catherine Blake   +3 more
openalex   +1 more source

Non‐Synaptic Function and Localization of Syntaxin‐Binding Protein 1 in a Mouse Model of STXBP1‐Related Epileptic Encephalopathy

Annals of Neurology, EarlyView.
Objective De novo mutations in the syntaxin‐binding protein 1 (STXBP1), encoded by STXBP1, are among the most prevalent causes of variable neurodevelopmental disorders, including epileptic encephalopathy, developmental delay, and movement disorders.
Tao Yang, Rajat Banerjee, Yamei Deng, Sheetal Jahagirdar1, Alexey I. Nesvizhskii, Michael D. Uhler, Jack M. Parent, Yu Wang   +7 more
wiley   +1 more source