Results 91 to 100 of about 1,046,440 (397)

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source

A medium composition containing normal resting glucose that supports differentiation of primary human airway cells

Scientific Reports, 2022
Primary cells isolated from the human respiratory tract are the state-of-the-art for in vitro airway epithelial cell research. Airway cell isolates require media that support expansion of cells in a basal state to maintain the capacity for ...
Rachel Morgan, Candela Manfredi, Kristen F. Easley, Lionel D. Watkins, William R. Hunt, Steven L. Goudy, Eric J. Sorscher, Michael Koval, Samuel A. Molina   +8 more
doaj   +1 more source

Social interactions in the Burkholderia cepacia complex : biofilms and quorum sensing [PDF]

, 2010
Burkholderia cepacia complex bacteria are opportunistic pathogens that cause respiratory tract infections in susceptible patients, mainly people with cystic fibrosis. There is convincing evidence that B.
Coenye, Tom
core   +2 more sources

Wireless Technologies for Wearable Electronics: A Review

Advanced Electronic Materials, EarlyView.
This review discusses recent advancements in wireless wearable electronics, focusing on communication technologies and power solutions. It covers key design considerations, explores wireless protocols from short‐ to long‐range networks, and examines powering methods such as integrated sources and energy harvesting.
Choong Yeon Kim, Juhyun Lee, Eun Young Jeong, Yeji Jang, Heesoo Kim, Bohyung Choi, Donggi Han, Youngjun Oh, Jae‐Woong Jeong   +8 more
wiley   +1 more source

Charting the landscape of the environmental exposome

iMeta, Volume 1, Issue 4, December 2022., 2022
We describe the biological and chemical components of the environmental exposomes in three major environmental matrices that are highly relevant to human and social‐economical health—air, soil, and water. We discuss how different exposome components can interact with each other. Finally, we propose a list of outstanding challenges to be tackled to push
Xin Wei, Zinuo Huang, Liuyiqi Jiang, Yueer Li, Xinyue Zhang, Yuxin Leng, Chao Jiang   +6 more
wiley   +1 more source

Interactions between the gut microbiome and host gene regulation in cystic fibrosis

Genome Medicine, 2019
Cystic fibrosis is the most common autosomal recessive genetic disease in Caucasians. It is caused by mutations in the CFTR gene, leading to poor hydration of mucus and impairment of the respiratory, digestive, and reproductive organ functions ...
Gargi Dayama, S. Priya, D. Niccum, A. Khoruts, R. Blekhman   +4 more
semanticscholar   +1 more source

Institutional learning curve and factors of prolonged operation time of robotic distal pancreatectomy: An analysis of an initial 117 cases

Annals of Gastroenterological Surgery, EarlyView.
This study verified the effective implementation of robotic distal pancreatectomy as the standard approach in our strategic robotic surgical oncology program. Although an institutional learning curve was observed, the robotic surgery program successfully expanded the number of primary operating surgeons while maintaining stable short‐term outcomes ...
Yuki Hirata, Laura Prakash, Jess Maxwell, Rebecca Snyder, Michael Kim, Hop Tran Cao, Ching‐Wei D. Tzeng, Jefferey E. Lee, Matthew H. G. Katz, Naruhiko Ikoma   +9 more
wiley   +1 more source

Dynamic Risk Prediction Triggered by Intermediate Events Using Survival Tree Ensembles [PDF]

arXiv, 2020
With the availability of massive amounts of data from electronic health records and registry databases, incorporating time-varying patient information to improve risk prediction has attracted great attention. To exploit the growing amount of predictor information over time, we develop a unified framework for landmark prediction using survival tree ...
arxiv  

Compressed Genotyping [PDF]

, 2009
Significant volumes of knowledge have been accumulated in recent years linking subtle genetic variations to a wide variety of medical disorders from Cystic Fibrosis to mental retardation. Nevertheless, there are still great challenges in applying this knowledge routinely in the clinic, largely due to the relatively tedious and expensive process of DNA ...
arxiv   +1 more source

TAS2R38 is a novel modifer gene in patients with cystic fbrosis [PDF]

, 2020
The clinical manifestation of cystic fbrosis (CF) is heterogeneous also in patients with the same cystic fbrosis transmembrane regulator (CFTR) genotype and in afected sibling pairs.
Amato, F., Carnovale, V, Castaldo, A, Cernera, G, Cimbalo, C, Comegna, M, DI LULLO, ANTONELLA MIRIAM, Gelzo, M, Iacotucci, P, Raia, V, Tosco, A   +10 more
core   +1 more source