Results 151 to 160 of about 352,696 (330)

Side-effects to antibiotics in cystic fibrosis: dental changes in relation to antibiotic administration. [PDF]

, 1967
J.N. Swallow, Jordan D. Haller, William F. Young   +2 more
openalex   +1 more source

The upside of epilepsy: Theories of an evolutionary paradox

Epilepsia Open, EarlyView.
Abstract The persistence of common, heritable conditions, like epilepsy, that are associated with reduced reproductive fitness is an evolutionary paradox. Endogenous analgesic, anti‐depressant, and inflammatory mechanisms able to repair compromised functions can offer advantages in unexpected crises.
Alyssa Ailion, Christoph Helmstaedter, Annamaria Vezzani, Matthias J. Koepp   +3 more
wiley   +1 more source

A MOLECULAR ABNORMALITY OF URINARY MUCOPROTEIN IN CYSTIC FIBROSIS OF THE PANCREAS* [PDF]

, 1962
Myles Maxfield, William Wolins
openalex   +1 more source

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, EarlyView.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source

Reduced sialylation of airway mucin impairs mucus transport by altering the biophysical properties of mucin

Scientific Reports
Mucus stasis is a pathologic hallmark of muco-obstructive diseases, including cystic fibrosis (CF). Mucins, the principal component of mucus, are extensively modified with hydroxyl (O)-linked glycans, which are largely terminated by sialic acid.
Elex S. Harris, Hannah J. McIntire, Marina Mazur, Hinnerk Schulz-Hildebrandt, Hui Min Leung, Guillermo J. Tearney, Stefanie Krick, Steven M. Rowe, Jarrod W. Barnes   +8 more
doaj   +1 more source

Sweat gland function in cystic fibrosis. [PDF]

, 1966
G W Cage, Richard L. Dobson, Robert E. Waller   +2 more
openalex   +1 more source

Synthetic Biology‐Based Engineering Living Therapeutics for Antimicrobial Application

Exploration, EarlyView.
This perspective highlights synthetic biology‐driven antibacterial strategies, focusing on three innovative approaches: engineered bacteriophages for precision bacterial targeting, reprogrammed microbes that detect quorum‐sensing signals or metabolites to release antimicrobials, and engineering mammalian cells that recognize pathogen‐associated ...
Shun Huang, Shuihao Zhao, Haijie Zhao, Mingzhang Wen, Zhong Guo   +4 more
wiley   +1 more source

Cystic Fibrosis and Fertility [PDF]

, 1969
Douglas S. Holsclaw
openalex   +1 more source

Nanomolar-potency 'co-potentiator' therapy for cystic fibrosis caused by a defined subset of minimal function CFTR mutants. [PDF]

, 2019
Available CFTR modulators provide no therapeutic benefit for cystic fibrosis (CF) caused by many loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel, including N1303K. We previously introduced the
Finkbeiner, Walter E, Haggie, Peter M, Nielson, Dennis W, Phuan, Puay-Wah, Rivera, Amber A, Tan, Joseph-Anthony, Verkman, Alan S, Zlock, Lorna   +7 more
core  

Investigating the role of SARM1 in central nervous system

Ibrain, EarlyView.
Sterile‐α and Toll/interleukin 1 receptor (TIR) motif‐containing protein 1 (SARM1) is a pivotal molecule that has garnered extensive attention in neuroscience. As an intracellular molecule, SARM1 possesses various crucial biological functions in the nervous system.
Junjie Wang, Yuhang Shi, Jinglei Tian, Liming Tang, Fang Cao   +4 more
wiley   +1 more source