Results 151 to 160 of about 1,046,440 (397)

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations

Molecular Biology of the Cell, 2016
More than 2000 mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) have been described that confer a range of molecular cell biological and functional phenotypes.
Gudio Veit, R. Avramescu, Annette N. Chiang, Scott A. Houck, Z. Cai, K. Peters, Jeong-Soo Hong, H. Pollard, W. Guggino, W. Balch, W. Skach, G. Cutting, R. Frizzell, D. Sheppard, D. Cyr, E. Sorscher, J. Brodsky, G. Lukács   +17 more
semanticscholar   +1 more source

Safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858, a novel oral dipeptidyl peptidase‐1 inhibitor, in healthy volunteers: An integrated phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Dipeptidyl peptidase‐1 (DPP‐1) inhibitors have been studied for the treatment of neutrophil‐mediated inflammatory diseases including bronchiectasis, bronchial asthma and cystic fibrosis. This study evaluated the pharmacokinetics, pharmacodynamics, safety and tolerability of DPP‐1 inhibitor HSK31858 in healthy Chinese volunteers.
Yuhao Wang, Chao Yu, Mengyue Hu, Lu Wang, Meixia Chen, Hanmo Liu, Nan Wu, Jie Hou   +7 more
wiley   +1 more source

Pseudomonas aeruginosa Acquisition in Cystic Fibrosis Patients in Context of Otorhinolaryngological Surgery or Dentist Attendance: Case Series and Discussion of Preventive Concepts

Case Reports in Infectious Diseases, 2015
Introduction. P. aeruginosa is the primary cause for pulmonary destruction and premature death in cystic fibrosis (CF). Therefore, prevention of airway colonization with the pathogen, ubiquitously present in water, is essential.
Jochen G. Mainz, Andrea Gerber, Michael Lorenz, Ruth Michl, Julia Hentschel, Anika Nader, James F. Beck, Mathias W. Pletz, Andreas H. Mueller   +8 more
doaj   +1 more source

Hyperpharmacotherapy in ageing cystic fibrosis patients: The first report of an atypical hip fracture

Respiratory Medicine Case Reports, 2015
Cystic fibrosis (CF) is a common autosomal recessive disorder in Caucasian populations with respiratory, gastrointestinal and endocrine manifestations.
W.A.K. Al-Azzani, L. Evans, L. Speight, M. Lea-Davies, M.D. Stone, D. Lau, R.I. Ketchell, J. Duckers   +7 more
doaj   +1 more source

Ion mediated cross-shield driven mucous swelling kinetics [PDF]

arXiv, 2013
We present an experimentally guided, bi-phasic, multi-species ionic gel model to compare and make quantitative predictions on the viscoelastic properties of healthy mucus versus Cystic-Fibrosis infected mucus. The mixture theory consists of the mucus (polymer phase) and water (solvent phase) as well as several different ions: H$^+$, Na$^+$, Cl$^-$ and ...
arxiv  

Cystic Fibrosis of the Pancreas in Infants and Children [PDF]

, 1955

openalex   +1 more source

Modulator Therapy for Cystic Fibrosis: An Exploration of Current Research [PDF]

, 2020
Developing a drug therapy that addresses the root cause of cystic fibrosis (CF) by increasing CFTR protein levels has long been a research challenge. After genetic therapy failed because a suitable delivery system could not be found, researchers began ...
Rombocos, Jessalyn
core   +1 more source

Acceptance and well-being in adolescents and young adults with cystic fibrosis: a prospective study [PDF]

, 2011
Objective To prospectively investigate the role of acceptance in well-being in adolescents and young adults with cystic fibrosis (CF). Method A total of 40 adolescents and young adults with CF (ages 14-22 years) completed questionnaires assessing ...
Casier, Annabelle, Crombez, Geert, De Baets, Frans, Goubert, Liesbet, Huse, Danielle, Matthys, Dirk, Theunis, Marleen   +6 more
core   +2 more sources

Preclinical Therapeutic Efficacy of the Ciprofloxacin Azithromycin Sinus Stent for Pseudomonas aeruginosa Sinusitis

International Forum of Allergy &Rhinology, EarlyView.
Adam J. Skelton, Dong‐Jin Lim, Brenton T. Bicknell, Daniel Skinner, Shaoyan Zhang, Bradford A. Woodworth, Do‐Yeon Cho   +6 more
wiley   +1 more source

Fighting Antibiotic Resistance: Insights Into Human Barriers and New Opportunities

BioEssays, EarlyView.
Antibiotic resistance is a public health issue leading to the emergence of multi‐resistant bacteria. Human‐dependent factors are now driving the increase of resistance, notably through antibiotic misuse in human and animal health and environmental pollution.
Aubin Pitiot, Camille Rolin, Carole Seguin‐Devaux, Jacques Zimmer   +3 more
wiley   +1 more source