Results 61 to 70 of about 5,706,617 (283)

A Comprehensive Microbial Gene Catalog of the Human Airway Microbiome Across Anatomical Sites and Geographic Regions

Advanced Science, EarlyView.
An integrated Human Airway Microbiome Gene Catalog (iHAMGC) is constructed from 12,273 metagenomic airway samples, providing a high‐resolution reference of respiratory microbial genes. The catalog enables systematic exploration of taxonomic and functional variation across airway niches and geographic regions, revealing site‐specific and region ...
Qing Zhang, Dashu Li, Bo Liu, Yue Zhang, Min Li, Ruochun Guo, Yawen Ni, Shibin Chen, Biao Ni, Lijie Qiu, Guorui Xing, He Dong, Qiulong Yan, Shenghui Li, Xiaohui Zou, Bin Cao   +15 more
wiley   +1 more source

Elevated Paracellular Glucose Flux across Cystic Fibrosis Airway Epithelial Monolayers Is an Important Factor for Pseudomonas aeruginosa Growth. [PDF]

, 2013
People with cystic fibrosis (CF) who develop related diabetes (CFRD) have accelerated pulmonary decline, increased infection with antibiotic-resistant Pseudomonas aeruginosa and increased pulmonary exacerbations.
James P Garnett, Tarran Robert, Ward, Christopher, Ward Christopher, Michael A Gray, Baines, DL, Garnett, James P., Robert Tarran, Christopher Ward, Ward, C, Garnett, JP, Baker, EH, Brodlie Malcolm, Baker, Emma H., Tarran, Robert, Gray Michael A., Brodlie, Malcolm, Baker Emma H., Garnett James P., Brodlie, M, Deborah L Baines, Baines Deborah L., Gray, Michael A., Baines, Deborah L., Gray, MA, Malcolm Brodlie, Tarran, R, Emma H Baker   +27 more
core   +1 more source

Early growth in cystic fibrosis and the pathways to lung function [PDF]

, 2020
Cystic Fibrosis (CF) is an inherited disease multi-organ disease that predominately affects the lungs. A key feature of the disease is progressive lung disease, and the main cause of death is respiratory failure.
Macdougall, Amy Meryl
core   +1 more source

Generation of Nasal Cell‐Derived Human Alveolar Organoids and Organoid‐Macrophage Assembloids for in Vitro Lung Modeling

Advanced Science, EarlyView.
This study demonstrates the generation of human alveolar organoids from nasal cells, which, when co‐cultured with monocyte‐derived macrophages, promotes maturation of both components and forms alveolar assembloids resembling native alveoli. These alveolar organoids and assembloids offer accessible, physiologically relevant in vitro systems for ...
Man Chun Chiu, Shuxin Zhang, Cun Li, Yifei Yu, Zhixin Wan, Jingjing Huang, Wei Xue, Ying Zhou, Xiaoxin Zhu, Qiaoshuai Lan, Jiali Wu, Zijun Zhao, Yuhong Liu, Xinjie Meng, Lin Huang, Hin Chu, Honglin Chen, Kelvin Kai‐Wang To, Kwok Yung Yuen, Jie Zhou   +19 more
wiley   +1 more source

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation [PDF]

, 2014
Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by genetic manipulation or autophagy-stimulatory proteostasis regulators, such as cystamine, have positive effects on mouse models of human cystic fibrosis (CF). These measures
Salvadori L, De Gregorio, Fabiola, A. Zolin, Guido, Stefano, Villella, Valeria R., Angela Sepe (663715), Zolin, Anna, Carlo A. Leone, Pinna LA, Daniela De Stefano (131144), S. Esposito, Rosa GD, Andrea Venerando (460236), D. D. Stefano, Valeria R. Villella, Speranza Esposito (663714), Villella VR, Laura Salvadori (663717), Speranza Esposito, Antonella Tosco (214447), Anna Bossi (663721), A. Tosco, Sepe A, PETTOELLO MANTOVANI, MASSIMO, Stefano Guido, Valeria Raia (524374), F. . D. Gregorio, Esposito, Speranza, Zolin A, Pinna, Lorenzo A, Villella, Valeria R, Maiuri L, Maiuri MC, G. G. Kroemer, Venerando A, Carlo A Leone (663719), A. Bossi, M. Pettoello Mantovani, Maiuri, Maria C, Kroemer, Guido, Pettoello-Mantovani, Massimo, Anna Bossi, Gianni Bona (505628), A. Venerando, Sepe, Angela, M. C. Maiuri, Leone CA, Guido Kroemer (82802), Rosa Grassia, G. D. Rosa, Antonella Tosco, Pinna, Lorenzo A., Valeria R Villella (663713), Anna Zolin, Fabiola De Gregorio, L. A. Pinna, Mehta A, Gregorio FD, Raia V., C. A. Leone, Raia, Valeria, Venerando, Andrea, Fabiola De Gregorio (663716), Grassia R, G. Bona, PINNA, LORENZO, Anna Zolin (375161), L. Salvadori, Bossi, Anna, V. R. Villella, Maiuri, Luigi, Kroemer G, Gianni Bona, Salvadori, Laura, Massimo Pettoello-Mantovani (583212), Anil Mehta, Tosco A, Laura Salvadori, Anil Mehta (202506), A. Sepe, Tosco, Antonella, Maiuri, Maria C., Stefano DD, Mehta, Anil, Rosa Grassia (663718), R. Grassia, Esposito S, Luigi Maiuri, Bossi A, Stefano Guido (112114), De Stefano, Daniela, Massimo Pettoello Mantovani, A. Mehta, Giuseppe De Rosa (206289), S. Guido, De Rosa, Giuseppe, Grassia, Rosa, Guido S, Luigi Maiuri (663723), Lorenzo A Pinna (663722), Giuseppe De Rosa, Bona G, Maria C. Maiuri, Daniela De Stefano, L. Maiuri, V. Raia, Leone, Carlo A, Bona, Gianni, Valeria Raia, Angela Sepe, Maria C Maiuri (663720), Guido Kroemer, Leone, Carlo A.   +112 more
core   +1 more source

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source

North American Delphi Consensus Study on Sinonasal Malignancy Survivorship Care

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Survival for patients with sinonasal cancers has improved over the past decades, but there are no dedicated survivorship guidelines for this cohort. Objective To understand experts’ priorities and perspectives on key survivorship tenets (surveillance, second tumor screening, toxicity, and symptom management).
Matheus Sewastjanow‐Silva, Samagra Jain, Rita Snyder, Erin L. McKean, Ralph Abi Hachem, Nithin D. Adappa, J. Ken Byrd, Ricardo L. Carrau, Marc A. Cohen, Ivan H. El‐Sayed, Mathew N. Geltzeiler, Ehab Y. Hanna, Edward C. Kuan, Nyall R. London Jr., Zoukaa B. Sargi, Carl H. Snyderman, Marilene B. Wang, Ian J. Witterick, Shirley Y. Su   +18 more
wiley   +1 more source

Impact of Highly Effective Modulator Therapy on Olfactory‐Specific Gene Expression in People With Cystic Fibrosis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis is common in people with cystic fibrosis (PwCF). Highly effective modulator therapy (HEMT) has been shown to improve sinonasal outcomes. However, prior studies failed to show improvement in objective olfaction with HEMT, and the impact of HEMT on olfactory‐specific quality of life has yet to be studied ...
Michael R. Xiang, Ankit Chauhan, Gina Hong, Denis Hadjiliadis, Daniel Dorgan, Michael M. Rey, Samantha Kane, James N. Palmer, Nithin D. Adappa, Noam A. Cohen, Michael A. Kohanski, Jennifer E. Douglas   +11 more
wiley   +1 more source

Three‐dimensional geometric morphometric analysis of diaphragmatic dome motion in COPD patients

The Anatomical Record, EarlyView.
Abstract Diaphragmatic dysfunction is a hallmark of chronic obstructive pulmonary disease (COPD), especially in emphysema, where hyperinflation alters diaphragm geometry and impairs inspiratory mechanics. However, quantitative three‐dimensional (3D) assessments of diaphragmatic dome shape and motion across COPD phenotypes are limited.
José M. López‐Rey, Benoît Beyer, Elena García‐Vargas, Isabel Torres‐Sánchez, Francisco García‐Río, Markus Bastir   +5 more
wiley   +1 more source

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source