Results 101 to 110 of about 47,507 (264)

Neohesperidin Alleviates Ferroptosis in Doxorubicin‐Induced Cardiotoxicity via Mettl3‐m6A‐Nrf2 Signaling

open access: yesPhytotherapy Research, EarlyView.
Neohesperidin alleviates doxorubicin‐induced cardiotoxicity by inhibiting METTL3‐mediated m6A modification of Nrf2 mRNA, thereby regulating Nrf2 and suppressing ferroptosis. ABSTRACT Doxorubicin (DOX) has antitumor efficacy, but its clinical application is restricted by multiple side effects, especially cardiotoxicity.
Ruijia Wen   +9 more
wiley   +1 more source

Efficient water‐soluble blue/red‐emissive carbon dots matching plant absorption spectra: Synthesis, tunable control, and their applications in promoting plant growth

open access: yesResponsive Materials, EarlyView.
Guided by the spectral demand of plant photosystems, this review summarizes the synthesis, emission regulation, dual‐emission design, and gram‐scale production of CDs for agricultural applications. Spectrally matched blue‐ and red‐emissive CDs enhance plant light utilization by converting underutilized light into photosynthetically active radiation and
Yijing Chen   +5 more
wiley   +1 more source

Synthesis of Chiral Gold Nanostructures on Gold‐Coral‐Coated Transparent Conductive Oxide Substrates via [AuCl4]– and Cysteine Interactions for Enhanced Chiral Sensing

open access: yesSmall, EarlyView.
We developed hierarchical chiral Au nanostructures on Au coral structures on transparent conductive oxide substrates using only electrochemical methods. By controlling the interaction between [AuCl4]– and cysteine, we successfully tuned the morphology and circular dichroism of the resulting Au nanostructures.
Kenta Nakagawa   +7 more
wiley   +1 more source

Sulfasalazine Enhances Copper Toxicity in Danio rerio Larvae: Divergent Protective Roles of Deferoxamine and Ferrostatin‐1

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Copper is an environmental contaminant capable of disrupting redox homeostasis and impairing antioxidant defenses in aquatic organisms, thereby increasing susceptibility to oxidative stress. The cystine/glutamate antiporter (system xc−) plays a central role in maintaining intracellular glutathione (GSH) levels, a major antioxidant defense ...
Maria Vitória Takemura Mariano   +9 more
wiley   +1 more source

Gold and Nickel Release From Jeweller‐Purchased 10K and 14K Gold Earrings in Cysteine‐Modified Artificial Sweat

open access: yesContact Dermatitis, EarlyView.
Even expensive 10K and 14K gold earrings released measurable gold in cysteine‐modified artificial sweat, despite no detectable nickel. Surface gold content did not predict release, challenging assumptions that higher gold content means lower exposure. ABSTRACT Background Gold contact allergy is common, but its clinical relevance is often uncertain.
Mikkel Bak Jensen   +5 more
wiley   +1 more source

GENDER AND AGE DISTRIBUTION AND CHEMICAL COMPOSITION OF RENAL STONES

open access: yesGomal Journal of Medical Sciences, 2014
Background: Renal stones are commonest urological disease worldwide. The objective of this study was to analyze the chemical composition of renal stones in relation to gender and age in District Dera Ismail Khan and its adjacent areas, Pakistan ...
Ghazi Khan   +3 more
doaj  

Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance

open access: yesThe FEBS Journal, EarlyView.
Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley   +1 more source

Energetic dysregulations in psychotic disorders: Targets for new therapeutics

open access: yesThe FEBS Journal, EarlyView.
The present review synthesizes literature documenting aberrant energy production and use, specifically related to mitochondrial and redox dysregulation, in psychotic disorders. Findings from different levels of investigation—genetic, cellular, and in vivo imaging—converge on aberrant energy metabolism as a hallmark of psychotic disorders.
Jacey Anderson   +10 more
wiley   +1 more source

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