Results 191 to 200 of about 47,507 (264)

Ferroptosis as a target mechanism in heart and kidney disease. [PDF]

J Clin Invest
Singh SJ, Cheema B, Ardehali H.
europepmc   +1 more source

Metformin Inhibits Trophoblast Ferroptosis by Suppressing ATF2 and Activating the PI3K/Akt/Nrf2 Pathway to Improve Gestational Diabetes Mellitus

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Metformin suppresses ATF2 expression, activating the PI3K/Akt pathway and promoting Nrf2 nuclear translocation. This upregulates GPX4, inhibiting ferroptosis in trophoblast cells. Erastin blocks system Xc−, depleting GSH and promoting ferroptosis. LY294002 and ML385 inhibit the pathway, validating the mechanism.
Dandan Xia, Yuhui Zhang, Wenjie Liu, Siyu Li, Chenying Zhang, Guangtong She, Huiyan Wang   +6 more
wiley   +1 more source

PANX2 Suppresses Lung Adenocarcinoma Progression by Inducing Disulfidptosis and Enhancing Antitumor Immunity. [PDF]

Adv Sci (Weinh)
Chen Y, Liu ZY, Qu GW, Zeng RH, Yao WX, Zhou YB, Liang X, Lai YX.   +7 more
europepmc   +1 more source

Effects of Selenocysteine Substitution on the Cyclotide Kalata B2

ChemBioChem, Volume 27, Issue 18, 28 September 2026.
Selenocysteine (Sec) substitution of any of the native complementary cysteine (Cys) residues of the cyclotide kalata B2 preserves the structure, cytotoxicity, and membrane‐binding activity while enhancing its folding efficiency. The study shows the conservative nature and folding benefit of selenocysteine replacement in kalata B2.
Ramoncito Luis B. de Boda, Sónia Troeira Henriques, Yen‐Hua Huang, Christine C. Hernandez, Portia Mahal G. Sabido, David J. Craik   +5 more
wiley   +1 more source

Dual metabolic intervention nanoplatform co-delivering BAY-876 and L-cystine for Wilms tumor therapy via disulfidptosis-associated cytoskeletal collapse. [PDF]

J Nanobiotechnology
Luo J, Mi T, Wang J, Jin L, Mou Y, Hu X, Lei L, Rao J, Guo P, He D.   +9 more
europepmc   +1 more source

Exploring the Anticancer Potential of Schiff Base Complexes: A Mini‐Review

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
Schiff base metal complexes as promising anticancer agents: highlighting DNA interactions, cytotoxicity, molecular targets, and mechanisms of cancer cell death. Schiff bases are well known for their ability to form stable coordination compounds with several transition metals, making them valuable for medicinal chemistry purposes.
Atif Ahmad, Anam, Marcos V. Palmeira‐Mello, Sabir Khan, José Clayston Melo Pereira   +4 more
wiley   +1 more source

Correction for Adelmann et al., Lysosomal reduced thiols are essential for mouse embryonic development. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

The emerging role of disulfidptosis in metabolic synergistic death and cancer immunotherapy. [PDF]

Oncogenesis
Wu Z, Tang R, Xu J, Wang Y, Jin L, Liao Y, Li D, Zu C, Yang C, Yu X, Shi S.   +10 more
europepmc   +1 more source

Synergistic Crosslinking of Triglycidyl Ether of Resveratrol With Amino Acids as a Novel Pathway to Design Sustainable High‐Performance Thermosets

ChemSusChem, Volume 19, Issue 17, 14 September 2026.
This study explores the design of sustainable thermosets by crosslinking the triglycidyl ether of resveratrol with series of amino acids to tailor high‐performance thermosets with excellent thermal, mechanical, and environmental properties for advanced industrial applications.
Sandu Cibotaru, Roxana Dinu, David D. Swanson, Alice Mija   +3 more
wiley   +1 more source

Disruption of cysteine metabolism leads to synthetic lethality and <i>in vivo</i> fitness impairment in <i>Acinetobacter baumannii</i>. [PDF]

mBio
Pathak A, Saini S, Pathania R.
europepmc   +1 more source