Results 181 to 190 of about 55,240 (308)

A rapid HPLC method to simultaneously quantify therapeutic thiols and monitor their disulfide exchange reactions with cystine. [PDF]

Orphanet J Rare Dis
Hadjipour A, Gayatri G, Rioux P, Kavanagh ON.   +3 more
europepmc   +1 more source

N6‐methyladenosine‐RNA methylation promotes expression of solute carrier family 7 member 11, an uptake transporter of cystine for lipid reactive oxygen species scavenger glutathione synthesis, leading to hepatoblastoma ferroptosis resistance

Clinical and Translational Medicine, 2022
Ronald A. Hill, Yong‐Yu Liu
doaj   +1 more source

Targeting Ferroptosis to Overcome Radioresistance and Enhance Immunotherapy in Colorectal Cancer. [PDF]

Cells
Soltani Tehrani S, Olson SI, Kundu K, Ferrandon S, Kalady MF.   +4 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, Volume 7, Issue 2, Page 35-51, June 2026.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Nanobody‐Conjugated Theranostic Prodrug Targeting αvβ3 Integrin Enables Precision Cancer Therapy With Real‐Time Imaging

Advanced Healthcare Materials, Volume 15, Issue 22, 12 June 2026.
The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.
Sanu Karan, Hyunseung Lee, Rema Naskar, Mi Young Cho, Hye Sun Park, Eun Hee Han, Soumyadip Hore, Sun Hee Cho, Truc Ngoc Kim Lam, Taewoong Son, Tae Jung Park, Inkyu Hwang, Jonathan L. Sessler, Kwan Soo Hong   +13 more
wiley   +1 more source

Formation of a reducing microenvironment and regulation of protein supersulfidation by gut microbial supersulfides. [PDF]

Redox Biol
Uchiyama J, Shimizu Y, Unoki T, Kasamatsu S, Ida T, Ihara H, Kim YG, Hase K, Miura Y, Maehama T, Kusano M, Umezawa K, Akiyama M.   +12 more
europepmc   +1 more source

Mechanically Robust MXene‐Metal Polyphenol Network Hybrid Interfaces for Multifunctional Protection of Keratin Fibers

Advanced Materials Interfaces, Volume 13, Issue 11, 9 June 2026.
Hair keratin fibers inevitably deteriorate under UV exposure, heat, and dryness. A robust composite coating assembles delaminated Ti3C2 MXene nanosheets onto keratin surfaces through biocompatible metal‐polyphenol networks of EGCG. This hybrid layer simultaneously screens UV, dissipates heat, reinforces mechanical strength, suppresses static charge ...
Juyeon Kang, Bomin Kim, Minkyoung Kim, Juyeon Park, Saehan Choi, Won Jun Lee, Heewon Kim, Yoonsung Nam, Jongwon Shim   +8 more
wiley   +1 more source

Targeting NRF2 addiction in cancer: synthetic lethal strategies beyond direct inhibition. [PDF]

Front Cell Dev Biol
Gebru MT, Stokoe D.
europepmc   +1 more source

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, Volume 13, Issue 31, 4 June 2026.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

Oncogenic role of the SLC7A13-SLC3A1 cystine transporter in human luminal breast cancer and its cryo-EM structure. [PDF]

Protein Cell
Dong J, Shi T, Lin B, Liu X, Wei W, Geng Z, Liu M, Yan R, Dong JT.   +8 more
europepmc   +1 more source