The NF-κB-SLC7A11 axis regulates ferroptosis sensitivity in inflammatory macrophages. [PDF]
Yang M+9 more
europepmc +1 more source
Programmed Cell Death in Cancer
Cancer is one of the most common and lethal diseases globally, with programmed cell death (PCD) playing a pivotal role in its pathogenesis and treatment. This comprehensive review covers the origin, developmental trajectory, and mechanisms of various PCDs, as well as their molecular connections with cancers. Latest studies have increasingly highlighted
Yuang Wei+3 more
wiley +1 more source
<i>SLC7A11</i>-mediated cell death mechanism in cancer: a comparative study of disulfidptosis and ferroptosis. [PDF]
Zhu WW, Liu Y, Yu Z, Wang HQ.
europepmc +1 more source
Plant cystine-knot peptides: pharmacological perspectives.
B. Molesini+4 more
semanticscholar +1 more source
Dehydrocostus lactone (DCL) covalently binds to NLRP3 and effectively reduces the interaction between NEK7 and NLRP3, thereby blocking the assembly of NLRP3 inflammasome complex and subsequent activation in macrophages. Consequently, DCL inhibits the cleavage and maturation of pro‐IL‐1β and pro‐IL‐18, ultimately leading to the suppression of the ...
Qi Lv+14 more
wiley +1 more source
Metabolic evaluation and disease characteristics of urolithiasis in children from 2020 to 2024: a retrospective single-center study at the national children's medical center. [PDF]
Hu L, He K, Jin L, Yan X.
europepmc +1 more source
THE DETERMINATION OF THIOL AND DISULFIDE COMPOUNDS, WITH SPECIAL REFERENCE TO CYSTEINE AND CYSTINE
Kamenosuke Shinohara, Kively E. Padis
openalex +1 more source
Cystine Deprivation Triggers Programmed Necrosis in VHL-Deficient Renal Cell Carcinomas.
Xiaohu Tang+10 more
semanticscholar +1 more source
Mitochondria ATP Pro‐Ferroptosis by Adjusting the Conversion of PUFA to PUFA‐PLs
Glutamine deprivation can promote PUFA oxidation and PTGS2 expression through the upregulation of intracellular ROS, but not ferroptosis. Because glutamine deficiency exhausts mitochondrial ATP, thereby hinders the conversion of PUFA into their active form of PUFA‐CoA needed for lipid synthesis.
Chaoyi Xia+3 more
wiley +1 more source