Results 311 to 320 of about 112,393 (379)

Klebsiella pneumoniae contributes to altered cytotoxicity of thiopurines in vitro: Possible implications of biotransformation and bacterial metabolism

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 18, Page 4281-4298, September 2025.
Abstract Background and purpose Thiopurines are used in paediatric inflammatory bowel disease (IBD), but some patients do not respond. Because the gut microbiota influences drug efficacy and IBD‐patient microbiota presents increased bacterial abundance, we investigated the impact of candidate Enterobacteriaceae on drug cytotoxicity, metabolism and ...
Martina Franzin   +13 more
wiley   +1 more source

Targeting Ferroptosis: Emerging Insights into Osteoporosis Mechanisms. [PDF]

open access: yesBiology (Basel)
Yang H   +5 more
europepmc   +1 more source

Ferroptosis in Haematological Malignancies: From Regulatory Networks to Novel Therapeutic Opportunities

open access: yesJournal of Cellular and Molecular Medicine, Volume 29, Issue 17, September 2025.
ABSTRACT Haematological malignancies encompass a wide spectrum of blood cell disorders with diverse prognoses. Despite recent advances in therapy, many of these disorders remain incurable or exhibit relapse and drug resistance. Ferroptosis, an iron‐dependent form of cell death caused by lipid peroxidation, holds promise as a strategy to overcome the ...
Maryam Shayanmanesh   +2 more
wiley   +1 more source

Natural Agents Modulating Ferroptosis in Cancer: Molecular Pathways and Therapeutic Perspectives

open access: yesJournal of Cellular and Molecular Medicine, Volume 29, Issue 17, September 2025.
ABSTRACT Ferroptosis, a controlled cell death influenced by iron‐dependent lipid peroxidation, presents potential therapeutic targets for cancer treatment due to its unique molecular pathways and potential drug resistance. Natural compounds, such as polyphenols, flavonoids, terpenoids and alkaloids, can influence ferroptosis via important signalling ...
Md. Al Amin   +12 more
wiley   +1 more source

Amide Chemistry Enables Redox Locking of Cyclic Disulfides for Polypeptide Assembly

open access: yesAngewandte Chemie, Volume 137, Issue 34, August 18, 2025.
The stability of a family of cyclic dichalcogenides derived from cysteine is significantly enhanced against reductants upon acylation of the alpha‐amino group. Amide formation serves as a redox lock, offering a mechanism to achieve selectivity in the assembly of large cyclic polypeptides on a water‐compatible solid support.
Vincent Diemer   +4 more
wiley   +2 more sources

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