Results 181 to 190 of about 38,369 (222)
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Cytidine deaminase activity in abnormal pregnancy
International Journal of Gynecology & Obstetrics, 1993AbstractOBJECTIVE: To determine the usefulness of cytidine deaminase (CTD) activity in the prediction of abnormal pregnancy and the prognosis of fetal outcome. METHOD: The CTD activities in 367 pregnant women and 17 placentas and their cord sera were determined.
T, Okamura +3 more
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Activation-induced cytidine deaminase and active cytidine demethylation
Trends in Biochemical Sciences, 2015The regulation of demethylation in vertebrates has begun to be elucidated in the past decade. However, a possible involvement of activation-induced cytidine deaminase (AID) in this process remains uncertain. We survey the data supporting or casting doubt on such a role, and propose that there is no strong evidence for an involvement of AID in genome ...
Almudena R, Ramiro, Vasco M, Barreto
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Human Cytidine Deaminase: Understanding the Catalytic Mechanism
Nucleosides, Nucleotides and Nucleic Acids, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
COSTANZI S +7 more
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Activation-induced cytidine deaminase: in sickness and in health
Journal of Cancer Research and Clinical Oncology, 2020Activation Induced cytidine Deaminase (AID) is an essential enzyme of the adaptive immune system. Its canonical activity is restricted to B lymphocytes, playing an essential role in the diversification of antibodies by enhancing specificity and changing affinity. This is possible through its DNA deaminase function, leading to mutations in DNA.
Leonardo Alves de Souza Rios +2 more
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Determination of plasma cytidine deaminase activity by HPLC
Biomedical Chromatography, 1987AbstractCytidine deaminase is an enzyme of nucleic acid metabolism, the measurement of which has been proposed as a useful test for the early detection of pre‐eclamptic toxaemia in pregnancy. The enzyme converts the nucleoside cytidine to uridine, with the release of ammonia, and it is the measurement of this latter compound that forms the basis of the
D A, Richards +3 more
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Action of bacterial cytidine deaminase on 5,6-dihydrocytidine
Biochemistry, 1975Cytidine deaminase from Escherichia coli was found to catalyze the hydrolytic deamination of 5,6-dihydrocytidine, at a rate slightly lower than its rate of action on the normal substrate. The results suggest that nucleophilic addition by the enzyme at the 5,6 position of the substrate is not an essential part of catalysis, unless the active site is so ...
B E, Evans, G N, Mitchell, R, Wolfenden
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Activity of serum cytidine deaminase during pregnancy
BJOG: An International Journal of Obstetrics & Gynaecology, 1982Summary. A simple and reliable method for the estimation of cytidine deaminase (cytidine aminohydrolase; EC 3.5.4.5) activity in pregnancy serum is described. This enzyme does not require magnesium for activation and is also more stable than deoxycytidylate deaminase (dCMP deaminase, dCMP aminohydrolase; EC 3.5.4.12).
D D, Jones +3 more
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On the Role of Cytidine Deaminase in Cellular Metabolism
1986Pyrimidine nucleotides are synthesized either denovo or via salvage pathways from preformed pyrimidine compounds. The denovo pathway of UTP and CTP synthesis appears to be almost identical in the various organisms studied, while there are major differences in the pathways by which pyrimidine deoxynu-cleotides are synthesized.
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Base editing with a Cpf1–cytidine deaminase fusion
Nature Biotechnology, 2018The targeting range of CRISPR-Cas9 base editors (BEs) is limited by their G/C-rich protospacer-adjacent motif (PAM) sequences. To overcome this limitation, we developed a CRISPR-Cpf1-based BE by fusing the rat cytosine deaminase APOBEC1 to a catalytically inactive version of Lachnospiraceae bacterium Cpf1.
Xiaosa Li +11 more
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Hypermutation by intersegmental transfer of APOBEC3G cytidine deaminase
Nature Structural & Molecular Biology, 2008Deamination of cytidine residues in single-stranded DNA (ssDNA) is an important mechanism by which apolipoprotein B mRNA-editing, catalytic polypeptide-like (APOBEC) enzymes restrict endogenous and exogenous viruses. The dynamic process underlying APOBEC-induced hypermutation is not fully understood.
Roni, Nowarski +3 more
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