Results 1 to 10 of about 12,489 (172)

A Novel Peptide Nucleic Acid against the Cytidine Monophosphate Kinase of S. aureus Inhibits Staphylococcal Infection In Vivo [PDF]

Molecular Therapy - Nucleic Acids, 2019
Here, we report a novel bactericidal peptide nucleic acid (PNA) that can induce the antisense effect on the cytidine monophosphate kinase (Cmk) of Staphylococcus aureus, a putative essential component for bacterial species.
Hyung Tae Lee, Se Kye Kim, Jun Bong Lee
exaly   +4 more sources

Biological functions and clinical implications of the CMPK2 across multisystemic diseases [PDF]

Cell & Bioscience
Cytidine/Uridine monophosphate kinase 2 (CMPK2) is a crucial enzyme responsible for the phosphorylation of nucleotides, specifically converting cytidine monophosphate (CMP) and uridine monophosphate (UMP) into their respective diphosphates, known as ...
Jia Li, Qing Liu, Jie Yang, Ziyi Yang, Mingxin Zhang, Jie Zhang, Chao Sun   +6 more
doaj   +3 more sources

A double-blind, randomized, comparative study of the use of a combination of uridine triphosphate trisodium, cytidine monophosphate disodium, and hydroxocobalamin, versus isolated treatment with hydroxocobalamin, in patients presenting with compressive neuralgias [PDF]

Journal of Pain Research, 2017
Henrique Goldberg,1 Marco Antonio Mibielli,2 Carlos Pereira Nunes,2 Stephanie Wrobel Goldberg,3 Luiz Buchman,4 Spyros GE Mezitis,5 Helio Rzetelna,6 Lisa Oliveira,2 Mauro Geller,2 Fernanda Wajnsztajn7 1UERJ Medical School, Rio de Janeiro, Brazil; 2UNIFESO
Goldberg H, Mibielli MA, Nunes CP, Goldberg SW, Buchman L, Mezitis SG, Rzetelna H, Oliveira L, Geller M, Wajnsztajn F   +9 more
doaj   +3 more sources

SARS-CoV-2 nsp14 Exoribonuclease Removes the Natural Antiviral 3′-Deoxy-3′,4′-didehydro-cytidine Nucleotide from RNA

Viruses, 2022
The on-going global pandemic of COVID-19 is caused by SARS-CoV-2, which features a proofreading mechanism to facilitate the replication of its large RNA genome.
Nicholas H. Moeller, Kellan T. Passow, Daniel A. Harki, Hideki Aihara   +3 more
doaj   +2 more sources

Structure and function of cytidine monophosphate kinase from Yersinia pseudotuberculosis , essential for virulence but not for survival [PDF]

Open Biology, 2012
The need for new antibiotics has become pressing in light of the emergence of antibiotic-resistant strains of human pathogens. Yersinia pestis, the causative agent of plague, is a public health threat and also an agent of concern in biodefence.
K Ravi Acharya, Petra C F Oyston
exaly   +2 more sources

Alpha-synuclein amyloids catalyze the degradation of ATP and other nucleotides [PDF]

Scientific Reports
Intracellular accumulation of alpha-synuclein amyloids is a main pathological hallmark in a subgroup of human neurodegenerative diseases called synucleinopathies.
Claudio Castillo-Cáceres, Esteban Nova, Rodrigo Diaz-Espinoza   +2 more
doaj   +2 more sources

Hydrophilic interaction liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry for determination of nuclear and cytoplasmatic contents of nucleotides, nucleosides and their nucleobases in food yeasts

Talanta Open, 2021
Hydrophilic interaction liquid chromatography using a zwitterionic phase, coupled with high-resolution mass spectrometry based on quadrupole and time-of-flight mass analyser (HILIC-Q-TOF-MS) is applied for the determination of four nucleobases (adenine ...
Marta Pastor-Belda, Inmaculada Fernández-Caballero, Natalia Campillo, Natalia Arroyo-Manzanares, Manuel Hernández-Córdoba, Pilar Viñas   +5 more
doaj   +1 more source

Effective and repeatable chromatographic separation of 5 nucleotides in infant formula milk powder by ion-pair high-performance liquid chromatography–ultraviolet

Journal of Dairy Science, 2022
: A robust method using HPLC-UV was developed to improve the accuracy and repeatability of a quantitative method to detect 5 nucleotides (cytidine-monophosphate, uridine monophosphate, adenosine monophosphate, guanine monophosphate, and inosine ...
Yuanjia Chen, Lin Luo, Peiyan Feng, Baojun Xu, Xiaoqun Wei   +4 more
doaj   +1 more source

5′-CMP and 5′-UMP alleviate dexamethasone-induced muscular atrophy in C2C12 myotubes

Biochemistry and Biophysics Reports, 2023
Atrogin-1 and muscle RING finger 1 (MuRF1) are ubiquitin ligases specifically expressed during skeletal muscle atrophy and mediate muscle protein degradation.
Kosuke Nakagawara, Chieri Takeuchi, Kazuya Ishige   +2 more
doaj   +1 more source

The Metabolic and Non-Metabolic Roles of UCK2 in Tumor Progression

Frontiers in Oncology, 2022
Enhanced nucleoside metabolism is one of the hallmarks of cancer. Uridine-cytidine kinase 2 (UCK2) is a rate-limiting enzyme of the pyrimidine salvage synthesis pathway to phosphorylate uridine and cytidine to uridine monophosphate (UMP) and cytidine ...
Yi Fu, Yi Fu, Xin-dong Wei, Xin-dong Wei, Luoting Guo, Kai Wu, Jiamei Le, Jiamei Le, Yujie Ma, Yujie Ma, Xiaoni Kong, Ying Tong, Hailong Wu, Hailong Wu   +13 more
doaj   +1 more source