Results 11 to 20 of about 12,489 (172)

A new technique for the analysis of metabolic pathways of cytidine analogues and cytidine deaminase activities in cells

Scientific Reports, 2023
Deoxycytidine analogues (dCas) are widely used for the treatment of malignant diseases. They are commonly inactivated by cytidine deaminase (CDD), or by deoxycytidine monophosphate deaminase (dCMP deaminase).
Anna Ligasová, Barbora Piskláková, David Friedecký, Karel Koberna   +3 more
doaj   +2 more sources

Profile of Nucleotides and Nucleosides in Taiwanese Human Milk

Pediatrics and Neonatology, 2011
Human milk–borne nucleotides and their related metabolic products have been reported to have important physiological roles in breast-fed infants. The purpose of this study was to measure the concentrations of free nucleotides and nucleosides in human ...
Kuo-Yu Liao, Tzee-Chung Wu, Ching-Feng Huang, Chih-Chung Lin, I-Fei Huang, Lite Wu   +5 more
doaj   +2 more sources

Systematic Engineering of Escherichia coli for Efficient Production of Cytidine 5′-Monophosphate

ACS Omega
Cytidine 5′-monophosphate (CMP) was widely applied in the food and pharmaceutical industries. Currently, CMP is mainly produced by enzyme catalysis. However, the starting materials for enzyme catalysis were relatively expensive.
Min Zhou, Liyuan Wei, Chongzhi Wu, Wei Chen, Zhengju Tang   +4 more
doaj   +2 more sources

Selective Fluorimetric Detection of Pyrimidine Nucleotides in Neutral Aqueous Solution with a Styrylpyridine-Based Cyclophane

Chemistry, 2023
A styrylpyridine-containing cyclophane with diethylenetriamine linkers is presented as a host system whose association with representative nucleotides was examined with photometric and fluorimetric titrations.
Julika Schlosser, Julian F. M. Hebborn, Daria V. Berdnikova, Heiko Ihmels   +3 more
doaj   +1 more source

Crystallization as a selection force at the polymerization of nucleotides in a prebiotic context

iScience, 2023
Summary: Accumulation and selection of nucleotides is one of the most challenging problems surrounding the origin of the first RNA molecules on our planet.
Judit E. Šponer, Jiří Šponer, Jakub Výravský, Roman Matyášek, Aleš Kovařík, Wojciech Dudziak, Katarzyna Ślepokura   +6 more
doaj   +1 more source

The changes of umami substances and influencing factors in preserved egg yolk: pH, endogenous protease, and proteinaceous substance

Frontiers in Nutrition, 2022
The study investigated the changes of nucleotides, succinic acid, and free amino acids amounts in yolk and the causes leading to the changes after pickling to uncover the fundamental umami component of preserved egg yolk.
Binghong Gao, Binghong Gao, Xiaobo Hu, Hui Xue, Ruiling Li, Huilan Liu, Tianfeng Han, Yonggang Tu, Yan Zhao   +8 more
doaj   +1 more source

5′-CMP and 5′-UMP promote myogenic differentiation and mitochondrial biogenesis by activating myogenin and PGC-1α in a mouse myoblast C2C12 cell line

Biochemistry and Biophysics Reports, 2022
Ribonucleotides are basic monomeric building blocks for RNA considered as conditionally essential nutrients. They are normally produced in sufficient quantity, but can become insufficient upon stressful challenges.
Kosuke Nakagawara, Chieri Takeuchi, Kazuya Ishige   +2 more
doaj   +1 more source

Crystal structure of 4,4′-(diazenediyl)dipyridinium nitrate perchlorate

Acta Crystallographica Section E: Crystallographic Communications, 2022
The title compound, C10H10N42+·NO3−·ClO4−, was obtained unexpectedly by the reaction of Co(ClO4)2·6H2O and cytidine-5′-monophosphate with 4,4′-azopyridine in an aqueous solution of nitric acid.
Qi-Ming Qiu, Jian-Biao Song, Ai-Guo Dong, Chuan-Tao Li, Zhi-Yuan Zheng   +4 more
doaj   +1 more source

<em>Bacillus anthracis</em> Edema Factor Substrate Specificity: Evidence for New Modes of Action

Toxins, 2012
Since the isolation of <em>Bacillus anthracis</em> exotoxins in the 1960s, the detrimental activity of edema factor (EF) was considered as adenylyl cyclase activity only.
Roland Seifert, Stefan Dove, Martin Göttle   +2 more
doaj   +1 more source

Changes in Quality and Microflora of Lentinus edodes during Post-harvest Cold Storage [PDF]

Shipin Kexue, 2023
This study investigated the quality and microbial flora changes of Lentinu edodes during postharvest cold storage. L. edodes was picked with sterile gloves, treated with ozone and stored for up to 40 days at 2–4 ℃.
ZHANG Xiaoling, XU Xiaolu, DENG Bing, YUN Shaojun, FENG Cuiping
doaj   +1 more source