Results 11 to 20 of about 11,913 (180)

5′-CMP and 5′-UMP alleviate dexamethasone-induced muscular atrophy in C2C12 myotubes

Biochemistry and Biophysics Reports, 2023
Atrogin-1 and muscle RING finger 1 (MuRF1) are ubiquitin ligases specifically expressed during skeletal muscle atrophy and mediate muscle protein degradation.
Kosuke Nakagawara, Chieri Takeuchi, Kazuya Ishige   +2 more
doaj   +1 more source

The Metabolic and Non-Metabolic Roles of UCK2 in Tumor Progression

Frontiers in Oncology, 2022
Enhanced nucleoside metabolism is one of the hallmarks of cancer. Uridine-cytidine kinase 2 (UCK2) is a rate-limiting enzyme of the pyrimidine salvage synthesis pathway to phosphorylate uridine and cytidine to uridine monophosphate (UMP) and cytidine ...
Yi Fu, Yi Fu, Xin-dong Wei, Xin-dong Wei, Luoting Guo, Kai Wu, Jiamei Le, Jiamei Le, Yujie Ma, Yujie Ma, Xiaoni Kong, Ying Tong, Hailong Wu, Hailong Wu   +13 more
doaj   +1 more source

SARS-CoV-2 nsp14 Exoribonuclease Removes the Natural Antiviral 3′-Deoxy-3′,4′-didehydro-cytidine Nucleotide from RNA

Viruses, 2022
The on-going global pandemic of COVID-19 is caused by SARS-CoV-2, which features a proofreading mechanism to facilitate the replication of its large RNA genome.
Nicholas H. Moeller, Kellan T. Passow, Daniel A. Harki, Hideki Aihara   +3 more
doaj   +1 more source

Selective Fluorimetric Detection of Pyrimidine Nucleotides in Neutral Aqueous Solution with a Styrylpyridine-Based Cyclophane

Chemistry, 2023
A styrylpyridine-containing cyclophane with diethylenetriamine linkers is presented as a host system whose association with representative nucleotides was examined with photometric and fluorimetric titrations.
Julika Schlosser, Julian F. M. Hebborn, Daria V. Berdnikova, Heiko Ihmels   +3 more
doaj   +1 more source

Crystallization as a selection force at the polymerization of nucleotides in a prebiotic context

iScience, 2023
Summary: Accumulation and selection of nucleotides is one of the most challenging problems surrounding the origin of the first RNA molecules on our planet.
Judit E. Šponer, Jiří Šponer, Jakub Výravský, Roman Matyášek, Aleš Kovařík, Wojciech Dudziak, Katarzyna Ślepokura   +6 more
doaj   +1 more source

The changes of umami substances and influencing factors in preserved egg yolk: pH, endogenous protease, and proteinaceous substance

Frontiers in Nutrition, 2022
The study investigated the changes of nucleotides, succinic acid, and free amino acids amounts in yolk and the causes leading to the changes after pickling to uncover the fundamental umami component of preserved egg yolk.
Binghong Gao, Binghong Gao, Xiaobo Hu, Hui Xue, Ruiling Li, Huilan Liu, Tianfeng Han, Yonggang Tu, Yan Zhao   +8 more
doaj   +1 more source

Determination of Serum Nucleotidase with Cytidine Monophosphate as Substrate, (I) [PDF]

Clinical Chemistry and Laboratory Medicine, 1975
This paper deals with a new method for the determination of serum nucleotidase (EC 3.1.3.5). The assay is performed with cytidine-5'-monophosphate as substrate, followed by deamination of the generated cytidine. The principle of the method and the determination of the liberated ammonia by the Berthelot indophenol-reaction are comparable to the Persijn--
Kooij, P. J. van der, PERSIJN, J.-P., Slik, W. van der, Korsten, C. B.   +3 more
openaire   +2 more sources

5′-CMP and 5′-UMP promote myogenic differentiation and mitochondrial biogenesis by activating myogenin and PGC-1α in a mouse myoblast C2C12 cell line

Biochemistry and Biophysics Reports, 2022
Ribonucleotides are basic monomeric building blocks for RNA considered as conditionally essential nutrients. They are normally produced in sufficient quantity, but can become insufficient upon stressful challenges.
Kosuke Nakagawara, Chieri Takeuchi, Kazuya Ishige   +2 more
doaj   +1 more source

Profile of Nucleotides and Nucleosides in Taiwanese Human Milk

Pediatrics and Neonatology, 2011
Human milk–borne nucleotides and their related metabolic products have been reported to have important physiological roles in breast-fed infants. The purpose of this study was to measure the concentrations of free nucleotides and nucleosides in human ...
Kuo-Yu Liao, Tzee-Chung Wu, Ching-Feng Huang, Chih-Chung Lin, I-Fei Huang, Lite Wu   +5 more
doaj   +1 more source

Crystal structure of 4,4′-(diazenediyl)dipyridinium nitrate perchlorate

Acta Crystallographica Section E: Crystallographic Communications, 2022
The title compound, C10H10N42+·NO3−·ClO4−, was obtained unexpectedly by the reaction of Co(ClO4)2·6H2O and cytidine-5′-monophosphate with 4,4′-azopyridine in an aqueous solution of nitric acid.
Qi-Ming Qiu, Jian-Biao Song, Ai-Guo Dong, Chuan-Tao Li, Zhi-Yuan Zheng   +4 more
doaj   +1 more source