Results 71 to 80 of about 2,416 (164)

A Glycoproteome Data Mining Strategy for Characterizing Structural Features of Altered Glycans with Thymic Involution

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This study presents a comprehensive data mining strategy for in‐depth extraction of overall and altered glycan features from structural and site‐specific glycoproteome data across various biomedical samples. The strategy enables the uncovery of four major altered glycan features associated with thymic involution and reveals their coordinated ...
Zhida Zhang, Yongqi Wu, Ke Hou, Yiwen Zhang, Lin Chen, Muyao Yang, Zhehui Jin, Yongchao Xu, Yingjie Zhang, Yinli Cai, Jiayu Zhao, Shisheng Sun   +11 more
wiley   +1 more source

Four‐gene Prognostic Signature and Risk of Brain Metastasis of Lung Adenocarcinoma

Molecular Carcinogenesis, Volume 64, Issue 7, Page 1209-1221, July 2025.
ABSTRACT Brain metastasis has a high incidence and poor prognosis in lung adenocarcinoma (LUAD). We sought to identify genes associated with LUAD brain metastasis and with the prognosis of patients with LUAD. Differential gene expression analysis was performed on LUAD patients with and without distant metastasis from the Cancer Genome Atlas (TCGA ...
Zheng Gong, Fengyuan Yu, Chen Li, Bingying Zhao, Miaowei Wen, Shanshan Zhang, Zhezhe Xu, Ailu Wu, Rukun Zang, Yuan Li, Hongwei Li, Yipeng Song   +11 more
wiley   +1 more source

Synthesis of sialoglycopolypeptide for potentially blocking influenza virus infection using a rat α2,6-sialyltransferase expressed in BmNPV bacmid-injected silkworm larvae [PDF]

, 2009
publishe
00397366, 1525, 1525, 2907, 2907, 2910, 2910, 2921, 2922, 2923, 2924, 2925, 2bfa7e53-ee2d-4af4-b215-37e9ff303ca8, 4d68973e-f6ff-4d7d-9439-c121d8831040, 50111802, 90238246, bd6a76a9-51e0-42ce-9e57-130004af2bc5, Kato, Koichi, Kato, Tatsuya, Nakajima, Makoto, Obara, Takakiyo, Ogata, Nakoto, Park, Enoch Y., Usui, Taichi, Yagi, Hirokazu   +24 more
core   +1 more source

Reduced binding of human antibodies to cells from GGTA1/CMAH KO pigs [PDF]

, 2014
Xenotransplantation using genetically modified pig organs could solve the donor organ shortage problem. Two inactivated genes that make humans unique from pigs are GGTA1 and CMAH, the products of which produce the carbohydrate epitopes, aGal and Neu5Gc ...
Burlak, C., Estrada, J., Li, P., Lutz, A. J., Paris, L. L., Sidner, R. A., Tector, A. J., Tector, M.   +7 more
core   +1 more source

Clinical Xenotransplantation of Gene‐Edited Pig Organs: A Review of Experiments in Living Humans Since 2022

Medicine Bulletin, Volume 1, Issue 1, Page 77-85, June 2025.
Recent clinical trials transplanted gene‐edited pig hearts, kidneys, and a liver into eight human patients, demonstrating xenotransplantation's potential to address organ shortages. While showing promise, outcomes varied, highlighting key challenges including immune rejection and managing patient comorbidities, requiring further optimization.
Lisha Mou, Zuhui Pu, David K. C. Cooper
wiley   +1 more source

The Renaissance of Bacillosamine and Its Derivatives: Pathway Characterization and Implications in Pathogenicity [PDF]

, 2013
Prokaryote-specific sugars, including N,N′-diacetylbacillosamine (diNAcBac) and pseudaminic acid, have experienced a renaissance in the past decade because of their discovery in glycans related to microbial pathogenicity.
Imperiali, Barbara, Morrison, Michael James   +1 more
core   +1 more source

Humoral Barrier to Preclinical and Clinical Xenotransplantation

Xenotransplantation, Volume 32, Issue 3, May/June 2025.
ABSTRACT Xenotransplantation is finally moving toward clinical application. Despite the progress in survival in preclinical models and the limited attempts at clinical heart transplantation, the initial problem of xenoreactive antibodies in human serum remains a proximal barrier to widespread success in preclinical and clinical settings.
A. Joseph Tector, Matt Tector, Sabrina Copsel, Zhang Yu Wang, Chris Burlak, Luz M. Reyes, Jose L. Estrada, Victor Novara Gennuso, Andrew B. Adams   +8 more
wiley   +1 more source

Immunometabolism of Liver Xenotransplantation and Prospective Solutions

Advanced Science, Volume 12, Issue 9, March 6, 2025.
After xenotransplantation, pig livers will replace those of human patients to maintain the stability of metabolism and immune system. The incompatibility of immunometabolism between humans and pigs induces rejection, inflammation, coagulation dysfunction, and liver failure. The profile of immunometabolism pre‐transplantation and post‐transplantation is
Shoulong Deng, Yi Zhang, Shasha Shen, Chongyang Li, Chuan Qin   +4 more
wiley   +1 more source

Exploring the multifaceted role of GNE in GNE myopathy [PDF]

101080249) and the Canada Research Coordinating Committee New Frontiers in Research Fund (NFRFG-2022-00033) for SIMPATHIC, and from the Government of Canada First Research Excellence Fund (CFREF) for the Brain-Heart Interconnectome (CFREF-2022-00007 ...
Barbosa, Mariana, Granjo, Pedro, Lochmüller, Hanns, Pereira, Beatriz L., Videira, Paula A.   +4 more
core   +1 more source

The role of genetically engineered pigs in xenotransplantation research [PDF]

, 2015
There is a critical shortage in the number of deceased human organs that become available for the purposes of clinical transplantation. This problem might be resolved by the transplantation of organs from pigs genetically engineered to protect them from ...
Ayares, David, Cooper, David K.C., Ekser, Burcin, Phelps, Carol, Ramsoondar, Jagdeece   +4 more
core   +1 more source