Results 61 to 70 of about 6,252 (195)

Translation of a Human‐Based Malaria‐on‐a‐Chip Phenotypic Disease Model for In Vivo Applications

Advanced Science, Volume 12, Issue 38, October 13, 2025.
Inoculation of the Malaria‐on‐a‐Chip model with human erythrocytes infected with Plasmodium falciparum can support the entire intraerythrocytic lifecycle for 7 days in vitro. Utilizing this human‐based, serum‐free model provides an alternative to animal testing by introducing a human‐based, preclinical alternative for antimalarial therapeutic delivery.
Michael J. Rupar, Hannah M. Hanson, Brianna L. Botlick, Narasimhan Sriram, Stephanie Rogers, Justin Zuniga, Zhanhe Liu, Steven J. Trimmer, Joseph M. Ciurca, Christopher J. Long, Christopher W. McAleer, Stephan Schmidt, Paola Favuzza, Philip Lowe, Nathalie Gobeau, James J. Hickman   +15 more
wiley   +1 more source

Microarray Analysis of PBMC after Plasmodium falciparum Infection: Molecular Insights into Disease Pathogenesis [PDF]

, 2011
Our laboratory’s previous microarray analysis of subjects with Plasmodium falciparum revealed up-regulation of Toll-like receptor, NF-kB, TNF-α, IFN-γ, IL-1β, p38 MAPK, and MHC molecules.
Alan Scott, Anne Jedlicka, August Louis Bourgeois, Nathan Wolfe, Sher Singh, Wan-Chung(Wan-Jiung) Hu   +5 more
core   +1 more source

Emerging Role of Splenic Macrophage in Malaria Pathogenesis and Immunity

Immunity, Inflammation and Disease, Volume 13, Issue 10, October 2025.
ABSTRACT Background Malaria, caused by Plasmodium parasites, remains a leading global health concern, impacting millions of people globally. Splenic macrophages are specialized immune cells that reside in the spleen and play a pivotal role in the pathogenesis and immune response during malaria.
Aarti Gupta, Meenu Kalkal, Jyoti Das
wiley   +1 more source

Vascular endothelial cells cultured from patients with cerebral or uncomplicated malaria exhibit differential reactivity to TNF. [PDF]

, 2011
Plasmodium falciparum malaria is a major cause of morbidity and mortality in African children, and factors that determine the development of uncomplicated (UM) versus cerebral malaria (CM) are not fully understood.
Wassmer, Samuel Crocodile, Moxon, Christopher A., Taylor, Terrie, Grau, Georges Emile, Molyneux, Malcolm E, Craig, Alister   +5 more
core   +3 more sources

Lycopene Mitigates Malaria‐Induced Reactive Oxygen and Nitrogen Species and Oxidative Damage in Mice Brain and Lungs

Parasite Immunology, Volume 47, Issue 8, August 2025.
ABSTRACT The severity of malaria is associated with low antioxidant availability and elevated free radical production, which induces oxidative damage in cerebral and pulmonary microcirculation. This can be mitigated by dietary antioxidants. We investigated the protective effects of lycopene (LYC) against oxidative changes induced by Plasmodium berghei (
Everton Luiz Pompeu Varela, Antônio Rafael Quadros Gomes, Aline da Silva Barbosa dos Santos, Mariana dos Santos Guimarães, Eliete Pereira de Carvalho, Oberdan Oliveira Ferreira, Mozaniel Santana de Oliveira, Marcello Iriti, Eloisa Helena de Aguiar Andrade, Sandro Percário   +9 more
wiley   +1 more source

An image-based drug susceptibility assay targeting the placental sequestration of Plasmodium falciparum-infected erythrocytes. [PDF]

PLoS ONE, 2012
Placental malaria is a significant cause of all malaria-related deaths globally for which no drugs have been developed to specifically disrupt its pathogenesis.
Min-Je Ku, Fernando de M Dossin, Michael A E Hansen, Auguste Genovesio, Lawrence Ayong, Lucio H Freitas-Junior   +5 more
doaj   +1 more source

Infectivity of Plasmodium falciparum in malaria-naive individuals is related to knob expression and cytoadherence of the parasite [PDF]

, 2016
Plasmodium falciparum is the most virulent human malaria parasite because of its ability to cytoadhere in the microvasculature. Nonhuman primate studies demonstrated relationships among knob expression, cytoadherence, and infectivity.
Beeson, James G., Chan, Jo-Anne A., Fink, James, Gerrard, John, Good, Michael F., Griffin, Paul M., Hackett, Hazel, Hanssen, Eric, Hoffman, Stephen L., Langer, Christine, Liu, Xue Q., McCarthy, James S., Pingnet, Jolien, Rodriguez, Ingrid B., Sekuloski, Silvana, Stanisic, Danielle I., Sundac, Lana, Trenholme, Katharine R., Wang, Claire Y. T., Yang, Yuedong, Zhou, Yaoqi   +20 more
core   +1 more source

Diet Driven Differences in Host Tolerance Are Linked to Shifts in Global Gene Expression in a Common Avian Host‐Pathogen System

Molecular Ecology, Volume 34, Issue 12, June 2025.
ABSTRACT Wildlife have become increasingly dependent on anthropogenic resources, altering interactions between individuals and subsequently disease transmission. Further, nutritional quantity and quality impact an individual's ability to mitigate damage caused by infectious disease.
Erin L. Sauer, Carson Stacy, Weston Perrine, Ashley C. Love, Jeffrey A. Lewis, Sarah E. DuRant   +5 more
wiley   +1 more source

The bacterial protein CNF1 as a new strategy against Plasmodium falciparum cytoadherence.

PLoS ONE, 2019
Plasmodium falciparum severe malaria causes more than 400,000 deaths every year. One feature of P. falciparum-parasitized erythrocytes (pRBC) leading to cerebral malaria (CM), the most dangerous form of severe malaria, is cytoadherence to endothelium and
Valeria Messina, Stefano Loizzo, Sara Travaglione, Lucia Bertuccini, Maria Condello, Fabiana Superti, Marco Guidotti, Pietro Alano, Francesco Silvestrini, Carla Fiorentini   +9 more
doaj   +1 more source

Comparison of apoptosis in human primary pulmonary endothelial cells and a brain microvascular endothelial cell line co-cultured with Plasmodium falciparum field isolates

BMC Infectious Diseases, 2017
Background Plasmodium falciparum infection can progress unpredictably to severe forms including respiratory distress and cerebral malaria. The mechanisms underlying the variable natural course of malaria remain elusive. Methods The cerebral microvascular
Jean Claude Biteghe Bi Essone, Nadine N’Dilimabaka, Julien Ondzaga, Jean Bernard Lekana-Douki, Dieudonné Nkoghe Mba, Philippe Deloron, Dominique Mazier, Frédrérick Gay, Fousseyni S. Touré Ndouo   +8 more
doaj   +1 more source