Results 61 to 70 of about 7,415 (242)
Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage [PDF]
Malaria Journal, 2011 The adhesion of Plasmodium falciparum parasitized red blood cell (PRBC) to human endothelial cells (EC) induces inflammatory processes, coagulation cascades, oxidative stress and apoptosis. These pathological processes are suspected to be responsible for the blood-brain-barrier and other organs' endothelial dysfunctions observed in fatal cases of ...
Issam Arrouss +9 more
openaire +4 more sources
Plasmodium falciparum:Rosettes do not protect merozoites from invasion-inhibitory antibodies [PDF]
, 2006 Rosetting is a parasite adhesion phenotype associated with severe malaria in African children. Why parasites form rosettes is unknown, although enhanced invasion or immune evasion have been suggested as possible functions.
Angus +27 more
core +1 more source
Virulence of malaria is associated with differential expression of Plasmodium falciparum var gene subgroups in a case-control study [PDF]
, 2006 Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a major pathogenicity factor in falciparum malaria that mediates cytoadherence. PfEMP1 is encoded by approximately 60 var genes per haploid genome.
Baea, Kay +5 more
core +1 more source
Traffic, Volume 23, Issue 9, Page 442-461, September 2022., 2022 Compound MMV396797 inhibits cytoadherence in malaria parasites. Abstract Plasmodium falciparum parasites which cause malaria, traffic hundreds of proteins into the red blood cells (RBCs) they infect. These exported proteins remodel their RBCs enabling host immune evasion through processes such as cytoadherence that greatly assist parasite survival.
Oliver Looker +5 more
wiley +1 more source
Response : Malaria Red Cell Cytoadherence [PDF]
Science, 1989 Discussion sur les methodes utilisees pour l'etude de la cytoadherence des erythrocytes infectes par Plasmodium falciparum. Certains auteurs preconisent la methode par perfusion ex vivo de la microcirculation du mesentere de rat qui permet la detection de l'adherence a l'endothelium des veinules et se rapproche des conditions ...
Cathleen Magowan +4 more
openaire +2 more sources
Clinical correlates of in vitro Plasmodium falciparum cytoadherence [PDF]
Infection and Immunity, 1991 To determine whether isolates of Plasmodium falciparum have intrinsically different cytoadherent properties and whether these differences contribute to the clinical severity of human falciparum malaria, we studied the cytoadherence to C32 melanoma cells in vitro of 59 parasite isolates from patients with naturally acquired infections in Thailand ...
Ho, M +5 more
openaire +4 more sources
The influence of host genetics on erythrocytes and malaria infection: is there therapeutic potential? [PDF]
, 2015 As parasites, Plasmodium species depend upon their host for survival. During the blood stage of their life-cycle parasites invade and reside within erythrocytes, commandeering host proteins and resources towards their own ends, and dramatically ...
Burgio, Gaetan +3 more
core +3 more sources
Inhibition of endothelial activation: a new way to treat cerebral malaria? [PDF]
, 2005 BACKGROUND: Malaria is still a major public health problem, partly because the pathogenesis of its major complication, cerebral malaria (CM), remains incompletely understood.
Cianciolo, George J +3 more
core +4 more sources
Plasmodium falciparum secretome in erythrocyte and beyond
Frontiers in Microbiology, 2016 Plasmodium falciparum is the causative agent of deadly malaria disease. It is an intracellular eukaryote and completes its multi-stage life cycle spanning the two hosts viz, mosquito and human.
Rani eSoni +2 more
doaj +1 more source
Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report. [PDF]
, 2010 BACKGROUND: Zoonotic malaria caused by Plasmodium knowlesi is an important, but newly recognized, human pathogen. For the first time, post-mortem findings from a fatal case of knowlesi malaria are reported here.
Adem, P +10 more
core +3 more sources