Results 1 to 10 of about 45,867 (238)
Journal of Cell Biology, 1972 Abstract Cytochalasin B (2 to 4 µg/ml) reversibly inhibits the chemotactic response of human and rabbit polymorphonuclear leukocytes to a bacterial chemotactic factor or to the complement derived factor, C5a. At lower concentrations (1 to 0.1 µg/ml or less) Cytochalasin B actually stimulates chemotaxis.
John T Harty
exaly +3 more sources
Metabolites, 2022 Endophytes have been shown to be a source of novel drug prototypes. The Casearia genus is known for presenting cytotoxic clerodane diterpenes; however, there are few reports on secondary metabolites produced by its fungal microbiota. Thus, in the present
Augusto L. Santos +7 more
doaj +1 more source
Effect of age and cytoskeletal elements on the indentation-dependent mechanical properties of chondrocytes. [PDF]
, 2013 Articular cartilage chondrocytes are responsible for the synthesis, maintenance, and turnover of the extracellular matrix, metabolic processes that contribute to the mechanical properties of these cells.
Blanchette, Craig +5 more
core +8 more sources
Nanomaterials, 2021 The evaluation of the frequency of micronuclei (MN) is a broadly utilised approach in in vitro toxicity testing. Nevertheless, the specific properties of nanomaterials (NMs) give rise to concerns regarding the optimal methodological variants of the MN ...
Tereza Cervena +7 more
doaj +1 more source
Frontiers in Immunology, 2021 Invertebrates, including earthworms, are applied to study the evolutionarily conserved cellular immune processes. Earthworm immunocytes (so-called coelomocytes) are functionally similar to vertebrate myeloid cells and form the first line of defense ...
Bohdana Kokhanyuk +5 more
doaj +1 more source
Journal of Pharmacological Sciences, 2020 The role of cytoskeleton dynamics in the oxidative stress toward human vasculature has been unclear. The current study examined whether the cytoskeleton-disrupting agent cytochalasin B reduces oxidative stress caused by high glucose in the human arterial
Kazumi Takaishi +5 more
doaj +1 more source
Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization,secondary mediators, and Rac [PDF]
, 2010 The C-type lectin-like receptor 2 (CLEC-2)activates platelets through Src and Syk tyrosine kinases via a single cytoplasmic YxxL motif known as a hem immunoreceptor tyrosine-based activation motif (hemITAM).Here, we demonstrate using sucrose gradient ...
Alice Y. Pollitt +44 more
core +1 more source
Marine Drugs, 2013 One new phenylalanine derivative 4′-OMe-asperphenamate (1), along with one known phenylalanine derivative (2) and two new cytochalasins, aspochalasin A1 (3) and cytochalasin Z24 (4), as well as eight known cytochalasin analogues (5–12) were isolated from
Xue-Ping Sun +8 more
doaj +1 more source
Occurrence and a possible mechanism of penetration of natural killer cells into k562 target cells during the cytotoxic interaction [PDF]
, 1995 The cytotoxic interaction between cloned human Natural Killer (NK) cells and K562 target cells was studied using confocal laser scanning microscopy (CLSM) and conventional fluorescence microscopy.
de Grooth, B.G. +6 more
core +3 more sources
Recovery of aging-related size increase of skin epithelial cells: in vivo mouse and in vitro human study. [PDF]
PLoS ONE, 2015 The size increase of skin epithelial cells during aging is well-known. Here we demonstrate that treatment of aging cells with cytochalasin B substantially decreases cell size.
Igor Sokolov +6 more
doaj +1 more source