Results 11 to 20 of about 45,867 (238)
Frontiers in Physiology, 2022 Alteration of the inward rectifier current IK1, carried by KIR2.1 channels, affects action potential duration, impacts resting membrane stability and associates with cardiac arrhythmias.
Encan Li +5 more
doaj +1 more source
Examination of actin and microtubule dependent APC localisations in living mammalian cells [PDF]
, 2006 (provisional) Background The trafficking of the adenomatous polyposis coli (APC) tumour suppressor protein in mammalian cells is a perennially controversial topic. Immunostaining evidence for an actin-associated APC localisation at intercellular
Adams, A. +4 more
core +3 more sources
Effect of Culture Conditions on Metabolite Production of Xylaria sp.
Molecules, 2015 Seeking a strategy for triggering the cryptic natural product biosynthesis to yield novel compounds in the plant-associated fungus Xylaria sp., the effect of culture conditions on metabolite production was investigated.
Hongqi Zhang +7 more
doaj +1 more source
In vitro markers for virulence in Yersinia ruckeri [PDF]
, 2010 In this study, different traits that have been associated with bacterial virulence were studied in Yersinia ruckeri. Two isolates that had been shown to cause disease and mortality in experimentally infected rainbow trout were compared with five ...
Chiers, Koen +5 more
core +2 more sources
Translational Oncology, 2015 An effective and inexpensive protocol for producing cytochalasins A and B is being disclosed to propose a viable method by which to examine the in vivo antineoplastic activity of these congeners in preclinical tumor-bearing mammalian models. In addition,
Matthew Trendowski +4 more
doaj +1 more source
Cytoskeletal Remodeling Mimics Endothelial Response to Microgravity
Frontiers in Cell and Developmental Biology, 2021 Mechanical cues contribute to the maintenance of a healthy endothelium, which is essential for vascular integrity. Indeed endothelial cells are mechanosensors that integrate the forces in the form of biochemical signals.
Laura Locatelli +2 more
doaj +1 more source
A pharmacological cocktail for arresting actin dynamics in living cells. [PDF]
, 2011 The actin cytoskeleton is regulated by factors that influence polymer assembly, disassembly, and network rearrangement. Drugs that inhibit these events have been used to test the role of actin dynamics in a wide range of cellular processes.
Peng, Grace E +2 more
core +2 more sources
Cell Journal, 2018 Objective The aim of current study was to provide a proof-of-concept on the mechanism of PLAU and PCDH10 gene expressions and caspases-3, -8, and -9 activities in the apoptotic pathway after treatment of malignant human glioma cell line (U87MG) with ...
Samaneh Heidarzadeh +2 more
doaj +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Cytochalasin B triggers a novel pertussis toxin sensitive pathway in TNF-alpha primed neutrophils
BMC Cell Biology, 2004 Background Cytochalasin B does not directly activate the oxygen-radical-producing NADPH oxidase activity of neutrophils but transfers desensitized G-protein coupled receptors (GPCR) into an active signaling state by uncoupling GCPR from the cytoskeleton.
Mellqvist Ulf-Henrik +6 more
doaj +1 more source