Results 101 to 110 of about 45,867 (238)

Lymphocyte Micronucleus Formation Is Driven by Inflammation‐Induced Oxidative DNA Damage in Oesophageal Cancer Development

International Journal of Cancer, EarlyView.
Chromosomal instability is a hallmark of cancer, but minimally invasive ways to detect systemic DNA damage and cancer risk remain limited. Here, using patient blood samples, the authors investigated lymphocyte micronuclei (MN) frequency as a potential marker of DNA damage across the progression from gastroesophageal reflux disease to Barrett's ...
Kathryn Munn, Rachel Lawrence, Hasan Haboubi, Hamsa Naser, Kate Hurlow, Ume‐Kulsoom Shah, Lisa Williams, Sarah Gwynne, Owen Bodger, Jiri Zavadil, Francois Virard, Shareen Doak, Laura E. Thomas, Gareth Jenkins   +13 more
wiley   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Cytochalasin-B-Inducible Nanovesicle Mimics of Natural Extracellular Vesicles That Are Capable of Nucleic Acid Transfer

Micromachines, 2019
Extracellular vesicles provide cell-to-cell communication and have great potential for use as therapeutic carriers. This study was aimed at the development of an extracellular vesicle-based system for nucleic acid delivery.
Anastasiya Oshchepkova, Alexandra Neumestova, Vera Matveeva, Lyudmila Artemyeva, Ksenia Morozova, Elena Kiseleva, Marina Zenkova, Valentin Vlassov   +7 more
doaj   +1 more source

Untreated Hair Dye Effluents Enter the Environment: Are They a Threat to Human Health?

Environmental Toxicology, EarlyView.
ABSTRACT The effluents generated during the process of hair dyeing exhibit a complex composition, comprising chemical compounds with varying toxicity levels. While the adverse impact of hair dyes on human health is acknowledged, there is a notable absence of studies addressing the toxicity associated with effluents produced during these activities. The
Letícia Cristina Gonçalves, Matheus Mantuanelli Roberto, Adriana Fabiana Corrêa da Silva, Maria Aparecida Marin‐Morales   +3 more
wiley   +1 more source

Nanomechanical and topographical imaging of living cells by Atomic Force Microscopy with colloidal probes [PDF]

, 2015
Atomic Force Microscopy (AFM) has a great potential as a tool to characterize mechanical and morphological properties of living cells; these properties have been shown to correlate with cells' fate and patho-physiological state in view of the development
Galluzzi, Massimiliano, Milani, Paolo, Podestà, Alessandro, Puricelli, Luca, Schulte, Carsten   +4 more
core   +2 more sources

Mitochondrial transfer in acute myeloid leukaemia and multiple myeloma: Mechanisms, consequences and potential therapeutic opportunities

The FEBS Journal, EarlyView.
Mitochondria can be transferred from bone marrow cells to cancer cells in acute myeloid leukaemia and multiple myeloma, boosting tumour energy production, growth, and drug resistance. This review highlights key transfer mechanisms and shows how targeting mitochondrial movement and dynamics may offer new therapeutic strategies to limit cancer ...
Ebubechukwu Nwarunma, Mark T. S. Williams   +1 more
wiley   +1 more source

Oocyte Enucleation Phase in Mouse Cloning [PDF]

International Journal of Fertility and Sterility, 2007
Abdolhossein Shahverdi, Rahman Fakhery, Azam Dalman   +2 more
doaj   +1 more source

Reciprocal and dynamic polarization of planar cell polarity core components and myosin

eLife, 2015
The Ciona notochord displays planar cell polarity (PCP), with anterior localization of Prickle (Pk) and Strabismus (Stbm). We report that a myosin is polarized anteriorly in these cells and strongly colocalizes with Stbm.
Erin Newman-Smith, Matthew J Kourakis, Wendy Reeves, Michael Veeman, William C Smith   +4 more
doaj   +1 more source

Illuminating cell signaling with genetically encoded FRET biosensors in adult mouse cardiomyocytes. [PDF]

, 2018
FRET-based biosensor experiments in adult cardiomyocytes are a powerful way of dissecting the spatiotemporal dynamics of the complicated signaling networks that regulate cardiac health and disease. However, although much information has been gleaned from
Chen-Izu, Ye, Jaradeh, Mark, Jian, Zhong, Reddy, Gopireddy Raghavender, Shi, Qian, Wang, Ying, West, Toni M, Xiang, Yang K   +7 more
core  

Mycobacterium avium Subsp. paratuberculosis and Human Endogenous Retrovirus in Italian Patients With Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS)

Immunology, EarlyView.
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a recognised gastrointestinal disorder. Mycobacterium avium subspecies paratuberculosis (MAP) is implicated in IBD pathogenesis. Persistent exposure and active infections by MAP may contribute to the unsilencing of human endogenous retroviruses (HERV ...
Stefano Ruberto, Alfredo Santovito, Gian P. Caviglia, Marta Noli, Davide Cossu, Davide G. Ribaldone, Demis Pitoni, Simona Frara, Elisa Tribocco, Chiara Rosso, Marta Guriglia, Ilaria Cossu, Pier A. Tovo, Massimiliano Bergallo, Leonardo A. Sechi   +14 more
wiley   +1 more source