Results 51 to 60 of about 48,300 (266)
Current Issues in Molecular Biology, 2022 To date, there are numerous protocols for the isolation of extracellular vesicles (EVs). Depending on the isolation method, it is possible to obtain vesicles with different characteristics, enriched with specific groups of proteins, DNA and RNA, which ...
Zarema Gilazieva +6 more
doaj +1 more source
Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene [PDF]
, 2007 G protein-coupled receptor regulation of gene transcription primarily occurs through the phosphorylation of transcription factors by MAPKs. This requires transduction of an activating signal via scaffold proteins that can ultimately determine the outcome
Adam J. Pawson +73 more
core +1 more source
Gelsolin's Protective Role in MASH through F‐Actin Regulation and P53 Degradation
Advanced Science, EarlyView.Gelsolin (GSN) maintains liver metabolic homeostasis by promoting MDM2‐mediated P53 degradation and inhibiting F‐actin/Yes‐associated protein (YAP) overactivation. Loss of GSN impairs P53 degradation, increases lipid deposition, and enhances YAP‐driven fibrosis and inflammation in metabolic‐associated steatohepatitis.
Yiwei Lu +9 more
wiley +1 more source
CELL SORTING IN THE PRESENCE OF CYTOCHALASIN B [PDF]
The Journal of Cell Biology, 1972 The ability of cytochalasin B to inhibit ruffled membrane activity and cellular locomotion of vertebrate cells in monolayer culture prompted its use to study the necessity for this kind of active cellular locomotion in cell sorting in heterotypic cell aggregates.
Armstrong, Peter B, Parenti, David
openaire +4 more sources
Analysis of Apoptosis on the Somatic Cell Nuclear Transfer embryos in porcine
Journal of Animal Reproduction and Biotechnology, 2018 The purpose of this study is to examined the electrofusion and activation conditions for the production of porcine somatic cell nuclear transfer (SCNT) embryos.
Ji-Eun Ryu, Jong-Taek Yoon
doaj +1 more source
A permeabilized cell model for studying cytokinesis using mammalian tissue culture cells. [PDF]
, 1980 PtK1 cells lysed late in cell division in a medium containing the nonionic detergent Brij 58 and polyethylene glycol with continue to undergo cleavage after lysis.
CANDE, W. Zacheus
core
The effects of exogenous lipid on THP-1 cells : an in vitro model of airway aspiration? [PDF]
, 2017 Chronic inflammatory diseases of the airways are associated with gastro-oesophageal reflux (GOR) and aspiration events. The observation of lipid laden macrophages (LLM) within the airway may indicate aspiration secondary to GOR.
Adams +6 more
core +2 more sources
Advanced Science, EarlyView.Annexin A3 (ANXA3) plays an endogenous protective role in endothelial dysfunction in sepsis by stabilizing the actin cytoskeleton, modulating cell permeability, and inhibiting pATF2/CD62E inflammatory signaling. Abstract Increased endothelial permeability and a dysregulated inflammatory response play key roles in organ damage in sepsis.
Manyu Xing +4 more
wiley +1 more source
The rate of hypo-osmotic challenge influences regulatory volume decrease (RVD) and mechanical properties of articular chondrocytes [PDF]
, 2015 Zhao Wang is funded on a China Scholarships PhD Studentship. Jerome Irianto was supported on a project grant from The Wellcome Trust (ref no. 084717)
Baaijens +61 more
core +1 more source
Advanced Science, EarlyView.This study develops enucleated MSC‐derived microvesicles (Mito@euMVs) to deliver functional mitochondria for optimizing wound repair. By efficiently encapsulating mitochondria, Mito@euMVs rejuvenate hyperglycemia‐induced senescent fibroblasts and HUVECs. Using PVA microneedle patches, the therapeutic efficacy of Mito@euMVs is validated in diabetic rats
Zixuan Dong +3 more
wiley +1 more source