Results 221 to 230 of about 330,393 (233)
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Cytochalasin D acts as an inhibitor of the actin–cofilin interaction
Biochemical and Biophysical Research Communications, 2012Cofilin, a key regulator of actin filament dynamics, binds to G- and F-actin and promotes actin filament turnover by stimulating depolymerization and severance of actin filaments. In this study, cytochalasin D (CytoD), a widely used inhibitor of actin dynamics, was found to act as an inhibitor of the G-actin-cofilin interaction by binding to G-actin ...
Kensaku Mizuno +4 more
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The effect of cytochalasin B and D on the fertilization of sea urchins
Developmental Biology, 1981Abstract Two electrical events occur across the plasma membrane of the sea urchin egg during the interaction with the fertilizing spermatozoon; the first, a step-like depolarization pecedes the fertilization potential (FP) by 11 sec at 20°C. Cytochalasins B and D alter these events in several ways depending upon dose and time of exposure of the ...
Amedeo De Santis, Brian Dale
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Effect of cytochalasin D on secretion by rat pancreatic acini
Cell Biology International Reports, 1983Using the model of isolated acini the effect of cytochalasin D (CD) on rat pancreatic secretion in vitro was studied. The influence of CD (0.01-10 micrograms/ml = 0.02-19.7 microM) on amylase secretion and 3H-pulse-labelled protein release was measured under two sets of conditions: (a) basal, and (b) stimulated by 77pM caerulein.
Peter C. Rathke +2 more
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A proposed mechanism of action of cytochalasin D on muscle actin
Biochemical and Biophysical Research Communications, 1980Summary Muscle F-actin diluted to 0.5 mM MgCl2 undergoes a decrease in viscosity which is increased in both rate and extent in the presence of cytochalasin D (CD). At the viscosity plateau, actin with CD hydrolyses ATP at an increased rate dependent on the CD concentration but activates myosin ATPase essentially the same as control actin.
Lewis C. Gershman +5 more
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The teratogenicity of cytochalasin D and its inhibition by drug metabolism
Teratology, 1981AbstractPregnant rats received intraperitoneal injections of cytochalasin D (CD) on gestational days 7–11. Doses of 400 μg/kg were only minimally and nonsig‐nificantly teratogenic, leading to 2 exencephalic fetuses among the 111 fetuses delivered.
Scott B. Selleck +4 more
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Arterial biomechanics after destruction of cytoskeleton by Cytochalasin D
Journal of Biomechanics, 2009Vascular smooth muscle is a major structural element of the arterial wall. We examined the effects of cytoskeleton destruction, after administration of Cytochalasin D, on the biomechanical properties of porcine common carotids. Compared to untreated, maximally dilated controls, Cytochalasin D-treated arteries have shown a marked increase in compliance ...
Tyler Thacher +3 more
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Villin-induced growth of microvilli is reversibly inhibited by cytochalasin D
Journal of Cell Science, 1993ABSTRACT Villin is an actin-binding protein that is associated with the cytoskeleton of brush border microvilli. In vitro, villin nucleates, caps or severs actin filaments in a Ca2+-dependent manner. In the absence of Ca2+, villin organizes microfilaments into bundles.
Thomas E. Kreis +2 more
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Characterization of a Cytochalasin D‐Resistant Mutant of Entamoeba histolytica
The Journal of Protozoology, 1989ABSTRACTCharacterization of a cytochalasin D‐resistant mutant of the human parasite Entamoeba histolytica capable of growing at 10 μM cytochalasin is described. The mutant cells also show resistance to 5 mM colchicine and 100 μM cytochalasin B, drugs proved deleterious for wild type trophozoites.
Brigido Gallegos +2 more
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Nocodazole and cytochalasin D induce tetraploidy in mammalian cells
American Journal of Physiology-Cell Physiology, 1984Nocodazole, a rapidly reversible inhibitor of microtubule assembly is useful for preparing mammalian cells synchronized at all stages of mitosis. When synchronized cells are allowed to progress through mitosis in the presence of cytochalasin D, the cleavage furrow is inhibited and dikaryon cells are formed.
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Cytochalasin D is able to mimic the effects of phalloidin on the rat liver
Experientia, 1979Cytochalasin D induces a strong potassium release in the isolated perfused rat liver and leads to vacuolization of the liver parenchymal cells. These effects are similar to the action of phalloidin on the rat liver. Since phalloidin and cytochalasin act in a different way on microfilaments, it is suggested that any disturbance of the function of ...
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