Results 21 to 30 of about 24,776 (201)

Assessing Als3 Peptide-Binding Cavity and Amyloid-Forming Region Contributions to Candida albicans Invasion of Human Oropharyngeal Epithelial Cells

Frontiers in Cellular and Infection Microbiology, 2022
Although it is widely recognized that disruption of ALS3 reduces the invasion of Candida albicans germ tubes into mammalian oral epithelial cells, the mechanism of this interaction was unexplored. C.
Soon-Hwan Oh, Lois L. Hoyer
doaj   +1 more source

TGFβ1-Induced Differentiation of Human Bone Marrow-Derived MSCs Is Mediated by Changes to the Actin Cytoskeleton

Stem Cells International, 2018
TGFβ is a potent regulator of several biological functions in many cell types, but its role in the differentiation of human bone marrow-derived skeletal stem cells (hMSCs) is currently poorly understood. In the present study, we demonstrate that a single
Mona Elsafadi, Muthurangan Manikandan, Sami Almalki, Mohammad Mobarak, Muhammad Atteya, Zafar Iqbal, Jamil Amjad Hashmi, Sameerah Shaheen, Nehad Alajez, Musaad Alfayez, Moustapha Kassem, Raed Abu Dawud, Amer Mahmood   +12 more
doaj   +1 more source

Src kinases regulate de novo actin polymerization during exocytosis in neuroendocrine chromaffin cells. [PDF]

PLoS ONE, 2014
The cortical actin network is dynamically rearranged during secretory processes. Nevertheless, it is unclear how de novo actin polymerization and the disruption of the preexisting actin network control transmitter release.
María José Olivares, Arlek M González-Jamett, María José Guerra, Ximena Baez-Matus, Valentina Haro-Acuña, Narcisa Martínez-Quiles, Ana M Cárdenas   +6 more
doaj   +1 more source

α1A-adrenergic receptor induces activation of extracellular signal-regulated kinase 1/2 through endocytic pathway. [PDF]

PLoS ONE, 2011
G protein-coupled receptors (GPCRs) activate mitogen-activated protein kinases through a number of distinct pathways in cells. Increasing evidence has suggested that endosomal signaling has an important role in receptor signal transduction.
Fei Liu, Kangmin He, Xinxing Yang, Ning Xu, Zhangyi Liang, Ming Xu, Xinsheng Zhao, Qide Han, Youyi Zhang   +8 more
doaj   +1 more source

Exploring the Substitution of the C21-OAc Moiety in [11]Cytochalasans: Synthesis and Evaluation of Fluorophore Conjugates. [PDF]

Chembiochem
Via in silico docking of pyrichalasin H on G‐ and F‐actin, the C21‐OAc moiety is identified as a modifiable site tolerated for actin binding. Fluorescent [11]cytochalasan probes from pyrichalasin H and epoxycytochalasin C are obtained by selective C21‐OAc hydrolysis and acylation.
Kagho MD, Schmidt K, Chakrabarti A, Karger M, Lambert C, Hauser M, Cox RJ, Rottner K, Stadler M, Stradal TE, Klahn P.   +10 more
europepmc   +2 more sources

Microgravity induces inhibition of osteoblastic differentiation and mineralization through abrogating primary cilia

Scientific Reports, 2017
It is well documented that microgravity in space environment leads to bone loss in astronauts. These physiological changes have also been validated by human and animal studies and modeled in cell-based analogs.
Wengui Shi, Yanfang Xie, Jinpeng He, Jian Zhou, Yuhai Gao, Wenjun Wei, Nan Ding, Huiping Ma, Cory J. Xian, Keming Chen, Jufang Wang   +10 more
doaj   +1 more source

Continuous, label-free, 96-well-based determination of cell migration using confluence measurement

Cell Adhesion & Migration, 2019
Cellular migration is essential in diverse physiological and pathophysiological processes. Here, we present a protocol for quantitative analysis of migration using confluence detection allowing continuous, non-endpoint measurement with minimal hands-on ...
Christian Mayr, Marlena Beyreis, Heidemarie Dobias, Martin Gaisberger, Julia Fuchs, Martin Pichler, Markus Ritter, Martin Jakab, Katharina Helm, Daniel Neureiter, Tobias Kiesslich   +10 more
doaj   +1 more source

A quantitative method to analyse F-actin distribution in cells

MethodsX, 2019
Changes in actin structure and distribution are involved in many cellular processes, such as differentiation, proliferation and migration. Differences in cell shape and size make the analysis of actin distribution difficult.
Jip Zonderland, Paul Wieringa, Lorenzo Moroni   +2 more
doaj   +1 more source

Role of phosphatidylinositol 4,5-bisphosphate in regulating EHD2 plasma membrane localization. [PDF]

PLoS ONE, 2013
The four mammalian C-terminal Eps15 homology domain-containing proteins (EHD1-EHD4) play pivotal roles in endocytic membrane trafficking. While EHD1, EHD3 and EHD4 associate with intracellular tubular/vesicular membranes, EHD2 localizes to the inner ...
Laura C Simone, Steve Caplan, Naava Naslavsky   +2 more
doaj   +1 more source

TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression

Advanced Science, EarlyView.
TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu, Jiabi Liang, Linda Zeng, Shuping Zhong, Xueling Fang, Yating Xu, Yongjian Wu, Xi Huang   +7 more
wiley   +1 more source