Results 111 to 120 of about 833,395 (340)

Stress as a Potential Regulatory Factor in the Outcome of Pharmacotherapy

Frontiers in Neuroscience, 2022
Maria Konstandi, Elizabeth O. Johnson, Matti A. Lang   +2 more
doaj   +1 more source

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Advanced Science, EarlyView.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao   +19 more
wiley   +1 more source

SENSITIVILITY PROFILE HEP-G2 AS A MODEL OF CYTOTOXIC ACTIVITY DETERMINATION OF BIOACTIVATED XENOBIOTICS VIA CYP ₄₅₀

Vitae, 2009
Several methodologies have been proposed in order to establish anticancer action, mainly focused on in vitro cytotoxicity valuation on neoplasic cell lines derived from human cancer.
Stephanie O. PRIETO, Fabio A. ARISTIZÁBAL G.   +1 more
doaj  

An Exploration of the Sub-Register of Chemical Engineering Research Papers Published in English

Publications, 2018
The increased pressures for high-volume, high-impact publications in English language and the high rejection rates of submitted manuscripts for publications present an often unsurpassable obstacle for (early career) researchers.
Myrto-Panagiota Zacharof, Anna Charalambidou   +1 more
doaj   +1 more source

Cytochrome P450 flexibility [PDF]

Proceedings of the National Academy of Sciences, 2003
Cytochrome P450 refers to a group of enzymes that catalyze the monooxygenation of various organic molecules in the following reaction: \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} \begin ...
openaire   +2 more sources

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

Smart Hydrogel Doped by Metal–Organic Frameworks for Renewable Self‐Pumping Enzymatic Reactors

Advanced Science, EarlyView.
Renewable self‐pumping enzymatic reactors based on thermo‐stimulated cyclic contraction/expansion of metal‐organic frameworks‐doped hydrogel. Abstract The construction of high‐performance immobilized enzymes is vastly desired for green biotransformation.
Yuxi Zhu, Shenghao Wang, Yueyuan Luo, Linbo Cao, Xiuxiu Guo, Yue Zhang, Mingmin Li, Tie Wang   +7 more
wiley   +1 more source

Electron Transfer of Cellobiose Dehydrogenase in Polyethyleneimine Films

ChemElectroChem
Cellobiose dehydrogenase (CDH) is applied as a bioelectrocatalyst in biosensors because its mobile cytochrome domain is capable of direct electron transfer.
Kwankao Karnpakdee, Dr. Daniel Kracher, Dr. Roland Ludwig   +2 more
doaj   +1 more source

HIGH DOSES OF IVERMECTIN CAUSE TOXIC EFFECTS AFTER SHORTTERM ORAL ADMINISTRATION IN RATS

Slovenian Veterinary Research
The anthelmintic macrocyclic lactones (MLs) are the most important endectocides in modern pharmacotherapy of parasitic infections. However, during the COVID 19 pandemic, ivermectin was used in humans against infection with the SARS-CoV-2 virus in doses ...
Vladimir Marjanović, Dragana Medić, Djordje Marjanović, Nenad Andrić, Miloš Petrović, Jelena Francuski Andrić, Milena Radaković, Darko Marinković, Vanja Krstić, Saša Trailović   +9 more
doaj   +1 more source

Cytochrome b5 reductase is the component from neuronal synaptic plasma membrane vesicles that generates superoxide anion upon stimulation by cytochrome c

Redox Biology, 2018
In this work, we measured the effect of cytochrome c on the NADH-dependent superoxide anion production by synaptic plasma membrane vesicles from rat brain.
Alejandro K. Samhan-Arias, Sofia Fortalezas, Cristina M. Cordas, Isabel Moura, José J.G. Moura, Carlos Gutierrez-Merino   +5 more
doaj   +1 more source