Results 221 to 230 of about 748,115 (294)

Early clinical pharmacology evaluation of the novel anti‐inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh   +5 more
wiley   +1 more source

Ligand architecture and secondary‐sphere effects in a well‐defined cobalt(IV)–oxo complex

open access: yesBulletin of the Korean Chemical Society, EarlyView.
A well‐defined cobalt(IV)–oxo complex supported by a neutral tetraazamacrocyclic ligand is generated and fully characterized. The cobalt(IV)–oxo species exhibits electrophilic oxygen‐atom and hydrogen‐atom transfer reactivity, strongly modulated by protonation and secondary coordination sphere effects, providing new insight into structure–reactivity ...
Ying Xing   +3 more
wiley   +1 more source

Lipid Dependence of CYP3A4 Activity in Nanodiscs. [PDF]

open access: yesBiology (Basel)
Denisov IG, Grinkova YV, Sligar SG.
europepmc   +1 more source

Introducing Experimental Design Concepts Improves Biochemistry Undergraduates' Experimental Laboratory Competence and Confidence

open access: yesBiochemistry and Molecular Biology Education, EarlyView.
ABSTRACT Laboratory science education can provide a training ground for developing experimental design capabilities, the ability to critically assess a range of laboratory methods, and confidence in selecting, adapting, and performing laboratory techniques.
Nathan D. Tivendale   +2 more
wiley   +1 more source

A Cytochrome c-Containing Periplasmic Nitrate Reductase in the Acetogen Sporomusa ovata. [PDF]

open access: yesEnviron Microbiol
Waschinger LM   +4 more
europepmc   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

open access: yesBMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan   +8 more
wiley   +1 more source

Cytosolic cytochrome c represses ferroptosis. [PDF]

open access: yesCell Metab
Song X   +11 more
europepmc   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

open access: yesBMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang   +12 more
wiley   +1 more source

Home - About - Disclaimer - Privacy