Results 241 to 250 of about 748,115 (294)

Chemotherapeutic Potential of Fluorouracil‐Platinum (IV) Prodrugs Against Cisplatin‐Resistant Colorectal Cancer Cells

Chemistry – A European Journal, EarlyView.
ABSTRACT Fluorouracil‐platinum(IV) prodrugs represent a novel class of multimechanistic chemotherapeutics with enhanced anticancer potential. The prodrugs PtIVP‐5FUMeOBut and PtIV56‐5FUMeOBut were actualized by derivatising the clinical drug 5‐fluorouracil (5FU) and coordinating it to platinum(IV) complexes, leveraging the established cytotoxicity of ...
Maria George Elias, Aleen Khoury, Shadma Fatima, Timothy J. Mann, Shawan Karan, Meena Mikhael, Paul de Souza, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich‐Wright   +9 more
wiley   +1 more source

Chemical engineering as an essential element of industrial biotechnology in Mexico: New aims in research and university education

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract On the centennial of higher education in Chemical Engineering in Mexico, it is pertinent to revisit the key stages that have contributed to its consolidation as a vital discipline for the nation's scientific and technological advancement. Although the initial mission of chemical engineering education was primarily oriented toward the training ...
Agustín López Munguía, Octavio T. Ramírez, Rafael Vazquez‐Duhalt, Eduardo Bárzana   +3 more
wiley   +1 more source

De novo synthesis of plant polyketide plumbagin in yeast: a platform for sustainable production of naphthoquinones. [PDF]

Nat Prod Bioprospect
Vasav AP, Barvkar VT.
europepmc   +1 more source

The Cu\u3csub\u3eA\u3c/sub\u3e Center of a Soluble Domain from \u3cem\u3eThermus\u3c/em\u3e cytochrome ba\u3csub\u3e3\u3c/sub\u3e. An NMR Investigation of the Paramagnetic Protein. A Proton NMR Study of the Paramagnetic Active Site of the Cu\u3csub\u3eA\u3c/sub\u3e Variant of Amicyanin [PDF]

, 1998
Holz, Richard C.
core   +1 more source

Mitochondria and the Actin Cytoskeleton in Neurodegeneration

Cytoskeleton, EarlyView.
ABSTRACT Mitochondrial dysfunction and cytoskeletal disorganization are widely recognized hallmarks of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS).
Shivani Tuli, Preet Patel, Aneri Shethji, David Gau   +3 more
wiley   +1 more source

Boric Acid Mitigates Alcohol-Induced Renal Podocyte Injury, Apoptosis, and Oxidative Stress in HBV Transgenic Mice. [PDF]

Antioxidants (Basel)
Sevgin K, Erguven P, Tanrikulu-Kucuk S, Degirmencioglu S, Cetinalp P, Aksu S, Gun-Atak P, Sogut I.   +7 more
europepmc   +1 more source

Pharmacogenomics of Major Depressive Disorder in Indigenous Amazonian Populations

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder is a highly prevalent psychological disorder worldwide and its main treatment is the use of Selective Serotonin Reuptake Inhibitors. However, few studies have demonstrated the relationship between the presence of genetic variants in pharmacogenes and the efficacy of these drugs, especially in populations with a unique genetic ...
Kaio Evandro Cardoso Aguiar, Natasha Monte da Silva, Juliana Carla Gomes Rodrigues, André Maurício Ribeiro‐dos‐Santos, Sandro José de Souza, Ândrea Ribeiro‐dos‐Santos, João Farias Guerreiro, Sidney Emanuel Batista dos Santos, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos   +9 more
wiley   +1 more source

Euro-Asian hybrids of Echinococcus multilocularis from red foxes in northern and northeastern Poland result from secondary contact between long-isolated populations. [PDF]

Sci Rep
Gładysz P, Bielińska-Wąż D, Wąż P, Samorek-Pieróg M, Karamon J, Lass A.   +5 more
europepmc   +1 more source

SLC25A39 identified as a key regulator of hepatocellular carcinoma progression through the mitochondrial ROS-cytochrome c-caspase signaling axis. [PDF]

Cell Mol Biol Lett
Yuan M, Du M, Yu J, Wang J, Xia T, Shen Q, Wang C, Li R.   +7 more
europepmc   +1 more source

Dimethyl fumarate and mitochondrial physiology: implications for neurological disorders. [PDF]

Front Pharmacol
de Oliveira MR.
europepmc   +1 more source