Vibrational energy relaxation (VER) of a CD stretching mode in cytochrome c [PDF]
We first review how to determine the rate of vibrational energy relaxation (VER) using perturbation theory. We then apply those theoretical results to the problem of VER of a CD stretching mode in the protein cytochrome c. We model cytochrome c in vacuum as a normal mode system with the lowest-order anharmonic coupling elements. We find that, for the ``
arxiv
DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications
DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding+5 more
wiley +1 more source
Imaging cytochrome C oxidase and FoF1-ATP synthase in mitochondrial cristae of living human cells by FLIM and superresolution microscopy [PDF]
Cytochrome C oxidase and FoF1-ATP synthase constitute complex IV and V, respectively, of the five membrane-bound enzymes in mitochondria comprising the respiratory chain. These enzymes are located in the inner mitochondrial membrane (IMM), which exhibits large invaginations called cristae.
arxiv
Leveraging Multifaceted Polyphenol Interactions: An Approach for Hair Loss Mitigation
This study presents tannic acid as an effective alternative to traditional hair loss treatments. Acting as an adhesion mediator, tannic acid binds to keratin on the hair surface and sequesters SCANDAL—a blend of salicylic acid, niacinamide, and dexpanthenol—allowing gradual release to hair follicles.
Eunu Kim, Geon Min Lee, Haeshin Lee
wiley +1 more source
Abstract α‐Chiral amines are versatile building blocks for the asymmetric synthesis of optically pure high‐added‐value chemicals, including pharmaceuticals, agrochemicals, and natural products. Herein, we report a one‐pot, two‐step sequential deracemization of racemic sec‐alcohols to optically enriched primary amines throught a photo‐biocatalytic ...
Natalia Antos+5 more
wiley +1 more source
Vibrational energy relaxation (VER) of isotopically labeled amide I modes in cytochrome c: Theoretical investigation of VER rates and pathways [PDF]
Using a time-dependent perturbation theory, vibrational energy relaxation (VER) of isotopically labeled amide I modes in cytochrome c solvated with water is investigated. Contributions to the VER are decomposed into two contributions from the protein and water.
arxiv
Inhalable Hsa‐miR‐30a‐3p Liposomes Attenuate Pulmonary Fibrosis
The study explores inhalable hsa‐miR‐30a‐3p‐loaded liposomes as a treatment for bleomycin‐induced pulmonary fibrosis in mice. Hsa‐miR‐30a‐3p is electroporated into liposomes and formulated into a dry powder for inhalation. Delivered via dry powder inhalation, it improves pulmonary function, promotes myofibroblast de‐differentiation by targeting CNPY2 ...
Shuo Liu+14 more
wiley +1 more source
Dynamics of protein-protein encounter: a Langevin equation approach with reaction patches [PDF]
We study the formation of protein-protein encounter complexes with a Langevin equation approach that considers direct, steric and thermal forces. As three model systems with distinctly different properties we consider the pairs barnase:barstar, cytochrome c:cytochrome c peroxidase and p53:MDM2.
arxiv +1 more source
In this study, saponin‐coated silica@gold nanocarriers responsive to NIR radiation is developed to enhance intratympanic drug delivery for cisplatin‐induced hearing loss (CIHL) treatment. The biocompatibility and oto‐protective properties are validated both in vitro and in vivo.
Rawand A. Mustafa+6 more
wiley +1 more source
Molecular Dynamics Simulations of Cytochrome c un-folding in AOT Reverse Micelles: the first steps [PDF]
This paper explores the reduced form of horse cytochrome c confined in reverse micelles (RM) of so-dium bis-(2-ethylhexyl) sulfosuccinate (AOT) in isooctane by molecular dynamics simulation. RMs of two sizes were constructed at a water content of Wo = [H2O]/[AOT] = 5.5 and 9.1.
arxiv