Results 21 to 30 of about 414,611 (257)

An innovative anticonvulsant - a GABAA receptor modulator with an alternative mechanism of action and enzyme-inducing detoxifying properties

European Psychiatry, 2021
Introduction The development of original drugs - new generation GABAA receptor modulators (GABAAR), with an anti-alcohol orientation, non-addictive and stimulating detoxification processes, makes it possible to increase the effectiveness of therapy and
T. Shushpanova, N. Bokhan, K. Stankevich, T. Novozheeva, O. Shushpanova, V. Udut, N. Garganeeva, E. Markova, E. Knyazeva, S. Safronov, R. Boev, A. Solonskii   +11 more
doaj   +1 more source

Murburn concept: a paradigm shift in cellular metabolism and physiology

Biomolecular Concepts, 2020
Two decades of evidence-based exploratory pursuits in heme-flavin enzymology led to the formulation of a new biological electron/moiety transfer paradigm, called murburn concept.
Manoj Kelath Murali
doaj   +1 more source

Identification, Expression and Activity of Candidate Nitrite Reductases From Orange Beggiatoaceae, Guaymas Basin

Frontiers in Microbiology, 2019
Orange filamentous Beggiatoaceae form massive microbial mats on hydrothermal sediments in Guaymas Basin; these bacteria are considered to oxidize sulfide with nitrate and nitrite as electron acceptors.
Andrew Buckley, Barbara MacGregor, Andreas Teske   +2 more
doaj   +1 more source

Widespread Distribution and Functional Specificity of the Copper Importer CcoA: Distinct Cu Uptake Routes for Bacterial Cytochrome c Oxidases

mBio, 2018
Cytochrome c oxidases are members of the heme-copper oxidase superfamily. These enzymes have different subunits, cofactors, and primary electron acceptors, yet they all contain identical heme-copper (CuB) binuclear centers within their catalytic subunits.
Bahia Khalfaoui-Hassani, Hongjiang Wu, Crysten E. Blaby-Haas, Yang Zhang, Federica Sandri, Andreia F. Verissimo, Hans-Georg Koch, Fevzi Daldal   +7 more
doaj   +1 more source

Novel nitrite reductase domain structure suggests a chimeric denitrification repertoire in the phylum Chloroflexi

MicrobiologyOpen, 2022
Denitrification plays a central role in the global nitrogen cycle, reducing and removing nitrogen from marine and terrestrial ecosystems. The flux of nitrogen species through this pathway has a widespread impact, affecting ecological carrying capacity ...
Sarah L. Schwartz, Lily Momper, Luiz Thiberio Rangel, Cara Magnabosco, Jan P. Amend, Gregory P. Fournier   +5 more
doaj   +1 more source

Iron Corrosion via Direct Metal-Microbe Electron Transfer

mBio, 2019
The concept that anaerobic microorganisms can directly accept electrons from Fe(0) has been controversial because direct metal-microbe electron transfer has previously only been indirectly inferred.
Hai-Yan Tang, Dawn E. Holmes, Toshiyuki Ueki, Paola A. Palacios, Derek R. Lovley   +4 more
doaj   +1 more source

Electrochemical Characterization of the Periplasmic PpcA c‐Cytochrome of Geobacter sulfurreducens Reveals Its Affinity for Uranium

ChemElectroChem, 2023
Geobacter bacteria produce conductive pili appendages and an outer membrane‐anchored lipopolysaccharide to immobilize uranium extracellularly. Yet, some radionuclide enters the cell envelope, where is rapidly mineralized by periplasmic c‐cytochromes.
Dr. Bhushan P. Awate, Prof. Robert M. Worden, Prof. Gemma Reguera   +2 more
doaj   +1 more source

Bespoke Biomolecular Wires for Transmembrane Electron Transfer: Spontaneous Assembly of a Functionalized Multiheme Electron Conduit

Frontiers in Microbiology, 2021
Shewanella oneidensis exchanges electrons between cellular metabolism and external redox partners in a process that attracts much attention for production of green electricity (microbial fuel cells) and chemicals (microbial electrosynthesis).
Samuel E. H. Piper, Marcus J. Edwards, Jessica H. van Wonderen, Carla Casadevall, Anne Martel, Lars J. C. Jeuken, Erwin Reisner, Thomas A. Clarke, Julea N. Butt   +8 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Effect of Salts on the Conformational Dynamics of the Cytochrome P450 OleP

Molecules, 2023
Cytochrome P450 OleP catalytic activity is strongly influenced by its structural dynamic conformational behavior. Here, we combine equilibrium-binding experiments with all-atom molecular dynamics simulations to clarify how different environments affect ...
Maria Laura De Sciscio, Alessandro Nicola Nardi, Giacomo Parisi, Giovanni Bulfaro, Antonella Costanzo, Elena Gugole, Cécile Exertier, Ida Freda, Carmelinda Savino, Beatrice Vallone, Linda Celeste Montemiglio, Marco D’Abramo   +11 more
doaj   +1 more source