Results 41 to 50 of about 499,967 (230)

Biogenesis of cytochrome c1 [PDF]

, 1989
The biogenesis of cytochrome c1 involves a number of steps including: synthesis as a precursor with a bipartite signal sequence, transfer across the outer and inner mitochondrial membranes, removal of the first part of the presequence in the matrix ...
Stuart, Rosemary A., Neupert, Walter, Nicholson, Donald W.   +2 more
core  

Early steps in mitochondrial protein import [PDF]

, 1990
The process of insertion of precursor proteins into mitochondrial membranes was investigated using a hybrid protein (pSc1-c) that contains dual targeting information and, at the same time, membrane insertion activity.
Stuart, Rosemary A., Neupert, Walter, Nicholson, Donald W.   +2 more
core   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

How are ‘atypical’ sulfite dehydrogenases linked to cell metabolism? – Interactions between the SorT sulfite deydrogenase and small redox proteins

Frontiers in Microbiology, 2011
Sulfite dehydrogenases are enzymes that catalyze the oxidation of the toxic and mutagenic compound sulfite to sulfate, thereby protecting cells from adverse effects associated with sulfite exposure.
Louie eLow, James Ryan Kilmartin, Paul V Bernhardt, Ulrike eKappler   +3 more
doaj   +1 more source

An innovative anticonvulsant - a GABAA receptor modulator with an alternative mechanism of action and enzyme-inducing detoxifying properties

European Psychiatry, 2021
Introduction The development of original drugs - new generation GABAA receptor modulators (GABAAR), with an anti-alcohol orientation, non-addictive and stimulating detoxification processes, makes it possible to increase the effectiveness of therapy and
T. Shushpanova, N. Bokhan, K. Stankevich, T. Novozheeva, O. Shushpanova, V. Udut, N. Garganeeva, E. Markova, E. Knyazeva, S. Safronov, R. Boev, A. Solonskii   +11 more
doaj   +1 more source

Yeast cytochrome c oxidase: a model system to study mitochondrial forms of the haem-copper oxidase superfamily.

, 2012
The known subunits of yeast mitochondrial cytochrome c oxidase are reviewed. The structures of all eleven of its subunits are explored by building homology models based on the published structures of the homologous bovine subunits and similarities and ...
Maréchal, A, Orengo, Christine, Amandine Maréchal, Peter R. Rich, Brigitte Meunier, Lee, David, Lee, D, Meunier, Brigitte, Maréchal, Amandine, Orengo, C, Meunier, B, Rich, Peter R., Christine Orengo, David Lee, Rich, PR   +14 more
core   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Cytochrome P450 2J2*7 Single-nucleotide Polymorphism and Nocturnal Hypertension in an Elderly Turkish Population

Gazi Medical Journal
Objective: Blood pressure shows a physiological diurnal rhythm. Altered blood pressure circadian rhythm is more common in the elderly. Nocturnal hypertension (NH) and/or impaired nocturnal dipping profile are associated with increased mortality risk. The
Elif Hilal Vural, Arzu Güneş Granberg, Atiye Çengel, Marja-Liisa Dahl, Hakan Zengil   +4 more
doaj   +1 more source

Murburn concept: a paradigm shift in cellular metabolism and physiology

Biomolecular Concepts, 2020
Two decades of evidence-based exploratory pursuits in heme-flavin enzymology led to the formulation of a new biological electron/moiety transfer paradigm, called murburn concept.
Manoj Kelath Murali
doaj   +1 more source

Unfolded States of Heme Proteins [PDF]

, 2010
Cytochromes adopt discrete structures when the heme cofactor is present. Since the heme provides crucial contacts in the native protein, this hydrophobic prosthetic group plays an important role in the folding mechanism and introduces interesting ...
Pribisko Yen, Melanie Anne
core   +1 more source