Results 71 to 80 of about 391,026 (214)

Photo‐Biomodulation of the Hippocampus Using Near‐Infrared Laser to Enhance Cognitive Function in Mice

Advanced Science, EarlyView.
Here a transcranial photo‐biomodulation approach is developed using near‐infrared (NIR) laser on hippocampus of mice, revealing significant improvements in learning and memory ability of mice under normal and disease conditions. The improvement results from the high‐density cell‐induced NIR local energy deposition, neuronal activation, and axonogenesis
Wei‐Tong Pan, Han‐Wen Gu, Yan‐Bo Zhou, Sophie Ma, Daqing Ma, Pan‐Miao Liu, Jian‐Jun Yang   +6 more
wiley   +1 more source

Semiconducting Open‐Shell Radicals for Precise Tumor Activatable Phototheranostics

Advanced Science, EarlyView.
A versatile phototheranostics nanoplatform of tumor‐specific activatable semiconducting open‐shell radicals for precise chemodynamic/photodynamic therapy (CDT/PDT) guided by “Turn On” second near‐infrared (NIR‐II) window fluorescence imaging (FLI) and PA imaging (PAI) through molecular engineering strategies. Abstract Semiconducting open‐shell radicals
Jie Zhang, Haifen Luo, Wen Ma, Jingqi Lv, Bo Wang, Fengwei Sun, Weijie Chi, Zhuting Fang, Zhen Yang   +8 more
wiley   +1 more source

The Encapsulation Strategies for Targeted Delivery of Probiotics in Preventing and Treating Colorectal Cancer: A Review

Advanced Science, EarlyView.
This work summarizes the efficacy and mechanisms of probiotics in CRC treatment, providing a comprehensive overview of various encapsulation methods such as microcapsules, hydrogels, single‐cell nanocoatings, and nanofibers for targeted probiotic delivery to inflammatory sites, with particular emphasis on the potential advantages of emerging single ...
Hao Zhong, Jin Jiang, Muhammad Hussain, Haoxuan Zhang, Ling Chen, Rongfa Guan   +5 more
wiley   +1 more source

Genetic population structure of the critically endangered stellate sturgeon (Acipenser stellatus) in the Black Sea basin: Implications for conservation

Aquatic Conservation: Marine and Freshwater Ecosystems, Volume 32, Issue 12, Page 1926-1939, December 2022., 2022
Abstract Stellate sturgeon (Acipenser stellatus) is a species of great conservation concern throughout its range. Over the past century, it has experienced a dramatic decline in abundance and distribution in the Black Sea basin. Information regarding the genetic structure of the species is very limited in the region, despite its crucial importance for ...
Daniela Nicoleta Holostenco, Mitică Ciorpac, Șirin Firidin, Oguzhan Eroglu, Devrim Memiș, Marian Paraschiv, Ștefan Honț, Marian Iani, Katarina Tošić, Elena Taflan, Daniela Porea, Petra Kersten, İlhan Aydın, Radu Suciu, Jörn Gessner, Geta Rîșnoveanu, Klaus Kohlmann   +16 more
wiley   +1 more source

Sulfur Bridge Geometry Boosts Selective FeIV═O Generation for Efficient Fenton‐Like Reactions

Advanced Science, EarlyView.
The sulfur bridge regulated the geometry and electronic effects of Fe diatomic pairs for selective and efficient generation of FeIV═O, opening an avenue to tune the microenvironment of active atomically dispersed sites and increase their loading amounts. Abstract High‐valent iron–oxo species (FeIV═O) is a fascinating enzymatic agent with excellent anti‐
Xunheng Jiang, Zhongyuan Guo, Jiang Xu, Zhiyu Pan, Chen Miao, Yue Chen, Hao Li, Hiroshi Oji, Yitao Cui, Graeme Henkelman, Xinhua Xu, Lizhong Zhu, Daohui Lin   +12 more
wiley   +1 more source

Identification of CD38high Monocyte as a Candidate Diagnostic Biomarker and Therapeutic Target for Sepsis

Advanced Science, EarlyView.
This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua, Limin Kong, Li Fan, Yanan Bai, Yujun Zhou, Yanfang Zhang, Qingwei Zhao, Xiaoyang Lu, Hongyu Yang, Hangyang Li, Peili Ding, Yuyu Nan, Qinghua Ji, Ping Yang, Lu Li, Yijing Xin, Lijuan Zhao, Wei Yang, Wenqiao Yu, Saiping Jiang   +19 more
wiley   +1 more source

Engineering Extracellular Vesicles Derived from 3D Cultivation of BMSCs Enriched with HGF Ameliorate Sepsis‐Induced Lung Epithelial Barrier Damage

Advanced Science, EarlyView.
3D culture of MSCs upregulates gene expression of matrix metalloproteinases (MMPs), growth factors (GFs), and increases the production of extracellular vesicles (EVs). Proteomic analysis reveals 642 upregulated proteins in 3D‐EVs, including HGF. These 3D‐EVs, enriched with HGF, protect lung epithelial cells from apoptosis and barrier damage in septic ...
Yong Chen, Feihong Lin, Tong Zhang, Zhuoran Xiao, Yuanli Chen, Dongsheng Hua, Yu Wang, Juan Wei, Tian Jin, Xin Lv   +9 more
wiley   +1 more source

Generation of a High‐Precision Whole Liver Panorama and Cross‐Scale 3D Pathological Analysis for Hepatic Fibrosis

Advanced Science, EarlyView.
Using the MOSTtechnology and whole‐liver Nissl staining method, a multi‐structural 3D pathological panorama of liver fibrosis is obtained. The damaged sinusoids, steatotic hepatocytes, and collagen deposition are all concentrated in pericentral areas.
Xiaochuan Zhang, Weicheng Yang, Xiaoliang Li, Yanli Zhao, Zongneng Xie, Shuangqu Li, Yue Zeng, Xiaoxu Hao, Xiaohong Xin, Yu Zhang, Zixuan Feng, Hualiang Jiang, Zhaobing Gao, Xianzhen Yin   +13 more
wiley   +1 more source

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

Aggregate, EarlyView.
Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu   +6 more
wiley   +1 more source

Gromomycins: An Unprecedented Class of Triterpene Antibiotics Produced by a Novel Biosynthetic Pathway

Angewandte Chemie, EarlyView.
Gromomycins represent a novel class of pentacyclic triterpene antibiotics with a unique biosynthetic pathway independent of the squalene route. These compounds exhibit potent activity against drug‐resistant Gram‐positive pathogens, including MRSA, and their unprecedented cyclization mechanism provides new insight into bacterial triterpene biosynthesis.
Stepan Tistechok, Dmytro Bratiichuk, Hilda Sucipto, Nils Gummerlich, Marc Stierhof, Oleksandr Gromyko, Franziska Fries, Victor Fedorenko, Rolf Müller, Josef Zapp, Maksym Myronovskyi, Andriy Luzhetskyy   +11 more
wiley   +2 more sources