Results 91 to 100 of about 604,858 (259)

A Knowledge‐Guided Graph Learning Approach Bridging Phenotype‐ and Target‐Based Drug Discovery

Advanced Science, EarlyView.
Knowledge‐Guided Drug Relational Predictor (KGDRP), a graph representation learning approach, effectively integrates multiple omics data, including biological network data, gene expression data, and sequence data that incorporates chemical molecular structures.
Qing Ye, Yundian Zeng, Linlong Jiang, Yu Kang, Peichen Pan, Jiming Chen, Yafeng Deng, Haitao Zhao, Shibo He, Tingjun Hou, Chang‐Yu Hsieh   +10 more
wiley   +1 more source

Prostate Cancer-Specific Lysine 53 Acetylation of Cytochrome c Drives Metabolic Reprogramming and Protects from Apoptosis in Intact Cells

Biomolecules
Cytochrome c (Cytc) is important for both mitochondrial respiration and apoptosis, both of which are altered in cancer cells that switch to Warburg metabolism and manage to evade apoptosis.
Paul T. Morse, Junmei Wan, Tasnim Arroum, Mackenzie K. Herroon, Hasini A. Kalpage, Viktoriia Bazylianska, Icksoo Lee, Elisabeth I. Heath, Izabela Podgorski, Maik Hüttemann   +9 more
doaj   +1 more source

Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low‐Temperature Photothermal Therapy via Targeting HSP90‐TXNDC9 Interactions

Advanced Science, EarlyView.
Icaritin demonstrates broad antitumor effects by inhibiting colorectal cancer (CRC) cell proliferation, migration, invasion, and causing cell cycle arrest. It induces apoptosis by repressing autophagic flux through disrupting HSP90‐TXNDC9 interactions.
Dan He, Siliang Chen, Xiaoyun Wang, Xiang Wen, Changyang Gong, Lei Liu, Gu He   +6 more
wiley   +1 more source

Cryo‐EM Analysis of a Tri‐Heme Cytochrome‐Associated RC‐LH1 Complex from the Marine Photoheterotrophic Bacterium Dinoroseobacter Shibae

Advanced Science, EarlyView.
Cryo‐EM reveals a closed 17‐subunit LH ring encircling the RC‐LH1 complex in Dinoroseobacter shibae, featuring a novel helix‐turn‐helix subunit bridging RC and LH. Mg2⁺/Ca2⁺ stabilizes the complex, while periplasmic Cyt c₂ mediates electron transfer via a tri‐heme Cyt to the special pair of bacteriochlorophylls. Insights into energy/electron efficiency
Weiwei Wang, Yanting Liu, Jiayi Gu, Shaoya An, Cheng Ma, Haichun Gao, Nianzhi Jiao, Jian‐Ren Shen, John Thomas Beatty, Michal Koblížek, Xing Zhang, Qiang Zheng, Jing‐Hua Chen   +12 more
wiley   +1 more source

The chromatographic behaviour of cytochrome c on cation exchangers [PDF]

, 1954
E. Margoliash
openalex   +1 more source

Dual‐Gating Strategy: Ultrasound Activation of TRPV2 Channels and Borate‐Glass‐Induced Calcium Overload for Tumor Suppression

Advanced Science, EarlyView.
A novel strategy combining borate glass and ultrasound is proposed for the precise treatment of breast cancer. The locally delivered borate glass releases Ca2⁺ ions in situ, while ultrasound activates the highly expressed transient receptor potential vanilloid 2 channels in breast cancer cells. This synergistic effect induces specific calcium overload,
Haihong Zhu, Liping Ouyang, Yangguang Huang, Ji Tan, Chunyu Liu, Qian Wang, Rongkun Huang, Wing Tak Wong, Xuanyong Liu, Haobo Pan, Yun Liao   +10 more
wiley   +1 more source

Mitigating Doxorubicin‐Induced Cardiotoxicity and Enhancing Anti‐Tumor Efficacy with a Metformin‐Integrated Self‐Assembled Nanomedicine

Advanced Science, EarlyView.
A novel self‐assembled nanomedicine (PMDDH) has been developed for the co‐delivery of doxorubicin and metformin, aiming to enhance the anti‐tumor efficacy of doxorubicin while alleviating its cardiotoxicity through the activation of cGAS‐STING and AMPK signaling pathways, respectively.
Jiaxin Huang, Jieru Yang, Yuanying Yang, Xiaofeng Lu, Juan Xu, Shan Lu, Hong Pan, Wenhu Zhou, Wenqun Li, Songwen Chen   +9 more
wiley   +1 more source

Cytochrome c and cancer cell metabolism: A new perspective

Saudi Pharmaceutical Journal
Cytochrome c is a vital electron carrier in the mitochondrial respiratory chain. When the outer membrane of mitochondria becomes permeable, cytochrome c is discharged into the cytoplasm, where it initiates the intrinsic apoptosis pathway.
Bader Alshehri
doaj  

A Polarographic Study on the Catalytic Effect of Catalase, Peroxidase, and Cytochrome C Ferments on the Cathodic Reduction of Hydrogen Peroxide. [PDF]

, 1947
B. Swedin, B. Ottar, B. Roald, Annikki Linnasalmi, Pentti Laukkanen   +4 more
openalex   +1 more source

High‐Throughput Proteoform Imaging for Revealing Spatial‐Resolved Changes in Brain Tissues Associated with Alzheimer's Disease

Advanced Science, EarlyView.
High‐throughput proteoform imaging (HTPi) is established by combining matrix‐assisted laser desorption ionization mass spectrometry imaging and high‐sensitivity region‐specific top‐down proteomic analysis. HTPi enables the generation of annotated proteoform images with exceptional precision, high throughput, and deep coverage, showing distinct spatial ...
Yue Sun, Dan Liu, Yu Liang, Xue Yang, Xinxin Liu, Baofeng Zhao, Zhen Liang, Yukui Zhang, Lihua Zhang   +8 more
wiley   +1 more source