Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication
NCOA4‐mediated ferritinophagy reprograms carnitine metabolism by disrupting Fe‐S cluster biogenesis, thereby establishing an iron‐lipid axis that suppresses various viruses, including PRRSV and IAV. However, viruses counteract this mechanism by degrading NCOA4.
Kaifeng Guan +7 more
wiley +1 more source
A unique mechanism of catalytic bias regulated by diaphorase‐like subunit in formate dehydrogenase from Rhodobacter aestuarii is revealed. The diaphorase‐like subunit functions act as a biological “voltage rheostat” that controls the slow release of NADH to regulate redox balance, biasing the enzyme's catalytic preference toward CO2 reduction over ...
Kuncheng Zhang +7 more
wiley +1 more source
A Cytochrome c-Containing Periplasmic Nitrate Reductase in the Acetogen Sporomusa ovata. [PDF]
Waschinger LM +4 more
europepmc +1 more source
On the Biosynthesis of Cytochrome c
M V, SIMPSON, D M, SKINNER, J M, LUCAS
openaire +2 more sources
PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes
A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li +10 more
wiley +1 more source
Sortase-mediated ligation of cytochrome c peroxidase and cytochrome c highlights the roles of dynamics and conformational specificity for interprotein electron transfer. [PDF]
Zawistowski RK, Clark JC, Crane BR.
europepmc +1 more source
Through HPLC–MS/MS analysis and multivariate statistics, raphani semen (RS) varieties with high functional components were screened. The white raphani semen “Xuebawang” was identified as ideal for further study due to its high bioactive content: glucoraphenin (9010.27 mg/100 g), glucoraphanin (1027.76 mg/100 g), sulforaphane (66.14 mg/100 g), and ...
Yonghua Li +10 more
wiley +1 more source
Gold Nanocluster-Promoted Interfacial Electron Transfer of Cytochrome c at an Aqueous-Organic Interface. [PDF]
Abad JM +3 more
europepmc +1 more source
m.10010T>C Mitochondrial Disease: A Case Report With Hypoparathyroidism and Review of the Literature
ABSTRACT Mitochondria are essential intracellular organelles that play a critical role in cellular metabolism, including the regulation of intracellular calcium signaling. Advances in genomic sequencing have facilitated the identification of rare pathogenic mitochondrial DNA (mtDNA) genetic variants in patients with unexplained endocrine disorders.
Jacob Mohr +5 more
wiley +1 more source
Mutant CHCHD10 disrupts cytochrome c oxidation and activates mitochondrial retrograde signaling. [PDF]
Campos-Ribeiro MA +13 more
europepmc +1 more source

