Results 131 to 140 of about 293,473 (312)

Semisynthetic cytochrome c site-67 substitutions

, 1990
Highly conserved tyrosine-67 of mitochondrial cytochrome $c$ is thought to be involved in important hydrogen bonding interactions in the hydrophobic heme pocket of the protein.
Frauenhoff, Mary Mills
core  

Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication

Advanced Science, EarlyView.
NCOA4‐mediated ferritinophagy reprograms carnitine metabolism by disrupting Fe‐S cluster biogenesis, thereby establishing an iron‐lipid axis that suppresses various viruses, including PRRSV and IAV. However, viruses counteract this mechanism by degrading NCOA4.
Kaifeng Guan, Chenyang Yuan, Zekun Meng, Yanan Wang, Xueying Zhai, Chunjie Huang, Xiang Zhou, Gaiping Zhang   +7 more
wiley   +1 more source

Cryo-EM structure of Chlamydomonas reinhardtii Photosystem I complexed with cytochrome c 6

Nature Communications
Photosynthetic electron transfer relies on small soluble carriers that shuttle electrons between the cytochrome b₆f complex and Photosystem I (PSI). While copper-containing plastocyanin (Pc) serves this role in plants, the heme protein cytochrome c₆ (Cyt
Yu Ogawa, Gyana Prakash Mahapatra, Yuval Milrad, Michelle Schimpf, Genji Kurisu, Michael Hippler, Jan Michael Schuller   +6 more
doaj   +1 more source

Amyloid fibril formation by bovine cytochrome c

, 2021
Ajuts: S.V. is supported by a "Ramón y Cajal" project awarded by the MCYT and co-financed by the Universitat Autonoma de Barcelona.Bovine heart cytochrome c is an all-α globular protein containing a covalently bound heme group. Prolonged incubation at 75°
Sánchez de Groot, Natalia, Ventura, Salvador   +1 more
core  

PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes

Advanced Science, EarlyView.
A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li, Qizhe Zhang, Hanchen Chen, Kepeng Lin, Chengfang Luo, Mengying Yang, Wei Xu, Fan Yao, Jianbing Yan, Qing‐Yong Yang, Xuehai Hu   +10 more
wiley   +1 more source

Studies of proton pumping mechanism in BA3 type cytochrome oxidase of thermus thermophilus and CBB3 type cytochrome oxidase of vibrio cholerae

, 2010
Oxygen reductase members of the heme-copper oxidoreductase superfamily are redox-driven proton pumps which couple the free energy liberated from the reduction of O2 to the translocation of protons across the membrane.
Chang, Hsin-Yang
core  

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Effects of TIIA, CT and CsA on hypoxia induced cytochrome c translocation.

, 2013
(A) Cell images illustrate mitochondria labelling with MitoTracker Orange CMTMRos (MitoTracker) (red) and cytochrome c (green) in H9c2 cells under normoxia and hypoxia conditions, and the effects of TIIA, CT and CsA treatments (yellow arrow: cytochrome ...
Hyou-Ju Jin (288780), Ji-Ming Ye (183929), Xiao-Liang Xie (288781), Chun-Guang Li (288782)   +3 more
core   +1 more source

How Advanced Artificial Intelligence Technologies Shape Drug–Drug and Drug–Target Interaction Modeling

Advanced Science, EarlyView.
This review explores the convergence of artificial intelligence technologies in modeling drug–drug and drug–target interactions. By evaluating advanced feature engineering, architectural innovations, and learning paradigms reveals shared evolutionary trends and critical challenges, such as cold‐start settings and shortcut learning.
Xin Sun, Tong Wang
wiley   +1 more source

Role of propolis and rosemary extract in improving mitochondrial efficiency and energy metabolism enzymes in late pregnancy Awassi sheep liver

Open Veterinary Journal
Background: The final stages of gestation in ewes are periods with very high energy requirements, with the energy needed to maintain homeostasis rising by 50%–75% compared to non-pregnancy conditions.
Faisal Ali Lattef, Mahaba Salah Mahdi Hassan Al_Zwelef, Mohammed T. Jaafar, Zainab Fadhil Abdulhussein, Ghadir Kamil Ghadir   +4 more
doaj   +1 more source